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Delivery of nitric oxide-releasing silica nanoparticles for in vivo revascularization and functional recovery after acute peripheral nerve crush injury

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Neural Regeneration Research 2022年第9期17卷 2043-2049页

作者： Jung Il Lee Ji Hun Park Yeong-Rim Kim Kihak Gwon Hae Won Hwang Gayoung Jung Joo-Yup Lee Jeong-Yun Sun Jong Woong Park Jae Ho Shin Myoung-Ryul Ok Department of Orthopedic Surgery College of MedicineKorea UniversitySeoulRepublic of Korea Medical Sensor Biomaterial Research Institute Kwangwoon UniversitySeoulRepublic of Korea Center for Biomaterials Korea Institute of Science&TechnologySeoulRepublic of Korea Department of Materials Science and Engineering Seoul National UniversitySeoulRepublic of Korea Department of Orthopedic Surgery College of MedicineCatholic UniversitySeoulRepublic of Korea Department of Chemistry Kwangwoon UniversitySeoulRepublic of Korea

Nitric oxide(NO)has been shown to promote revascularization and nerve regeneration after peripheral nerve injury.However,in vivo application of NO remains challenging due to the lack of stable carrier materials capable of storing large amounts of NO molecules and releasing them on a clinically meaningful time scale.Recently,a silica nanoparticle system capable of reversible NO storage and release at a controlled and sustained rate was introduced.In this study,NO-releasing silica nanoparticles(NO-SNs)were delivered to the peripheral nerves in rats after acute crush injury,mixed with natural hydrogel,to ensure the effective application of NO to the lesion.Microangiography using a polymer dye and immunohistochemical staining for the detection of CD34(a marker for revascularization)results showed that NO-releasing silica nanoparticles increased revascularization at the crush site of the sciatic nerve.The sciatic functional index revealed that there was a significant improvement in sciatic nerve function in NO-treated animals.Histological and anatomical analyses showed that the number of myelinated axons in the crushed sciatic nerve and wet muscle weight excised from NO-treated rats were increased.Moreover,muscle function recovery was improved in rats treated with NO-SNs.Taken together,our results suggest that NO delivered to the injured sciatic nerve triggers enhanced revascularization at the lesion in the early phase after crushing injury,thereby promoting axonal regeneration and improving functional recovery.

关键词： crush injury nerve injury,nerve regeneration nitric oxide peripheral nerve revascularization silica nanoparticles

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Effects of initial wettability and different surfactant-silica nanoparticles flooding scenarios on oil-recovery from carbonate rocks

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Petroleum 2022年第4期8卷 499-508页

作者： Amin Rezaei Amin Khodabakhshi Amir Esmaeili Mehdi Razavifar Abdal Industrial Projects Management Company(MAPSA) Pardis Technology ParkPardisTehranIran Department of Chemical Engineering Faculty of EngineeringMahshahr BranchIslamic Azad UniversityMahsharIran Department of Petroleum Engineering Amirkabir University of Technology(Tehran Polytechnic)TehranIran Enhanced Oil Recovery(EOR)Research Centre IOR/EOR Research InstituteShiraz UniversityShirazIran

Initial wettability of rock surfaces plays a crucial role in displacement efficiency during core flooding experiments.In this study,linear alkylbenzene sulfonic acid(LABSA)and silica nanoparticles(NPs)were utilized as enhanced oil recovery(EOR)agents to improve oil recovery from carbonate rock samples.Prior to the core flooding experiments,effects of the presence of LABSA and SiO_(2)NPs on oil-water interfacial tension(IFT),wettability alteration,and surfactant adsorption on the rock surfaces were evaluated.The results of IFT/contact angle measurements showed that by adding 0.03 wt%LABSA,the IFT,and contact angle reduced from the initial values of 36.9 mN/m and 115.6°±0.2°to 8.3 mN/m and 100.3°±0.4°,respectively.Furthermore,incorporating SiO_(2)NPs(0.1 wt%)into the system causes a further decrease in IFT value(dropped to 2.2 mN/m),along with a substantial reduction in contact angle(final contact angle after 6 h soaking into the solution was measured as 64.8°±0.3°).In addition,surfactant loss due to the adsorption on the rock surfaces decreased up to 35%in the presence of SiO_(2)NPs(0.1 wt%).Moreover,various core flooding scenarios in carbonate plugs with different initial wettability conditions were conducted,and the performance of the EOR agents in enhancing oil recovery from oilwet and water-wet core samples in the secondary and tertiary mode of flooding was evaluated.The outcomes revealed that the injection of a combination of chemicals,containing LABSA(0.03 wt%)and SiO_(2)(0.1 wt%)in the secondary mode leads to the highest ultimate oil recovery from sister carbonate core samples.

关键词： LABSA Enhanced oil recovery silica nanoparticles IFT Contact angle Adsorption Carbonates

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Effects of different gases on the performance of foams stabilized by Cocamidopropyl betaine surfactant and silica nanoparticles:A comparative experimental study

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Petroleum 2022年第4期8卷 546-551页

作者： Masoud Hatami Alooghareh Atefeh Kabipour Mohamadhosein ghazavi Seyyed Mohammad Mousavi Sisakht Mehdi Razavifar Department of Chemical Engineering Faculty of EngineeringShahid Chamran University of AhvazAhvazIran Islamic Azad University Khark BranchKhark IslandBoushehrIran Lamerd Higher Education Center Petroleum Engineering DepartmentLamerdFarsIran Department of Petroleum Engineering School of Chemical and Petroleum EngineeringShiraz UniversityShirazIran

Application of CO_(2)gas in foam enhanced oil recovery(EOR)processes has emerged as a win-win strategy for achieving higher oil recovery factor and reducing greenhouse gas emission,which can significantly help the protection of the ozone layer from depletion.However,lower stability of CO_(2)-foam,as compared to the N_(2)-and CH_(4)^(-)foams,has tempted us to examine combinations of CO_(2)with these gases to not only improve the stability of the produced foam but also have CO_(2)as the gaseous phase of the foam.In this study,we investigated the effect of different gases and the mixture thereof on the performance of foams in EOR while the aqueous phase of foams is a constant mixture of Cocamidopropyl betaine surfactant(0.03 wt%)and silica nanoparticle(0.1 wt%).To this end,seven different gases,including N_(2),CO_(2),CH4,80%N_(2)^(+)20%CO_(2),80%CH_(4)^(+)20%CO_(2),50%CH_(4)^(+)50%CO_(2),50%N_(2)^(+)50%CO_(2)were used as the gases phase for foam generation and the performance of the produced foams were examined through the following experiments:bulk foam stability tests,apparent foam viscosity measurements and core flooding tests.The results of foam stability tests showed that half-life time for the CO_(2)-,CH_(4)^(-)and N_(2)-foams are 13.5,17.0 and 44.0 min,respectively.Also,as revealed from apparent viscosity measurements,the N_(2)-and 80%N_(2)^(+)20%CO_(2)foams have higher apparent foam viscosity values followed by 50%N_(2)^(+)50%CO_(2)foam.Furthermore,we showed that a combination of 80%N_(2)^(+)20%CO_(2)as the gaseous phase for foam generation could not only improve CO_(2)-foam stability,as compared to other foams,but also can substantially increase ultimate oil recovery(56.6%OOIP),even more than that for N_(2) foam(48.6%OOIP),obtained from core flooding experiments.

关键词： Foam Carbon dioxide Nitrogen Methane silica nanoparticles Surfactant Mobility ratio

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Tailoring nanocomposite membranes of cellulose acetate/silica nanoparticles for desalination

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Journal of Materiomics 2022年第6期8卷 1122-1130页

作者： Amira S.Mohammed Ali Moataz M.Soliman Sherif H.Kandil Shaker Ebrahim Marwa Khalil Materials Science Department Institute of Graduate Studies and Research(IGSR)Alexandria University163 Horrya AvenueEl-ShatbyP.O.Box 83221526AlexandriaEgypt Nanotechnology and Composite Materials Department Advanced Technology and New Materials Research InstituteCity of Scientific Research and Technological Applications(SRTA-City)P.O.Box 21934New Borg El Arab CityAlexandriaEgypt

Herein, the fabrication of cellulose acetate (CA) silica-based nanocomposite membranes via the dry-wetphase inversion procedure for water desalination was investigated. The modified and unmodified silicananoparticles (MSNPs and SNPs) were prepared by the sol-gel technique. The effect of the SNPs andMSNPs was investigated on the CA membrane's properties and their performance for water desalination.The CA nanocomposite membranes were characterized to study their structure, hydrophilicity, andmorphology. The fabricated nanocomposite membranes showed hydrophilic surface properties. Theperformance of reverse osmosis (RO) membranes was measured using a crossflow RO unit at 10 bar(1 bar = 0.1 MPa). The membrane with 10 mg of SNPs enhanced permeate water flux compared to thepristine CA membrane by 1.6 L/(m2·h). The effect of MSNPs on the nanocomposites' performance waslower than their counterpart in the case of adding SNPs. The membrane with 30 mg of MSNPs showedthe highest permeate water flux among other nanocomposite membranes with a value oAQSf 35.7 L/(m2·h)at 24 bar.

关键词： silica nanoparticles Amino-modified silica Cellulose acetate Nanocomposite membrane Water desalination Reverse osmosis

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Effects of silica nanoparticles on growth and photosynthetic pigment contents of Scenedesmus obliquus

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Journal of Environmental Sciences 2010年第1期22卷 155-160页

作者： Chenxi Wei, Yanbo Zhang, Jing Guo, Bing Han, Xu Yang, Junlin Yuan Hubei Key Laboratory of Genetic Regulation and Integrative Biology, College of Life Sciences, Huazhong Normal University, Wuhan 430079, China. Hubei Key Laboratory of Genetic Regulation and Integrative Biology College of Life Sciences Huazhong Normal University Wuhan 430079 China

To assess the aquatic ecosystem safety for silica （SiO2） nanoparticles （NPs）, the growth inhibition and photosynthetic pigment contents of Scenedesmus obliquus in logarithm growth phase exposed to SiO2 NPs and SiO2 bulk particles （BPs） suspensions were measured. SiO2 NPs with 10-20 nm diameters were found to be toxic. The 20% effective concentration （EC20） values for 72 and 96 hr were 388.1 and 216.5 mg/L, respectively. The contents of chlorophyll decreased significantly under moderate and high concentration （50, 100, and 200 mg/L） of SiO2 NPs after 96-hr exposure, but the carotenoids did not. SiO2 BPs were found to be nontoxic up to 200 mg/L. The toxicity of SiO2 NPs probablely due to their sorption to algal cells surface. The results imply that there is potential harm to aquatic environment by using SiO2 NPs, and it should deserve special concern.

关键词： photosynthetic pigment Scenedesmus obliquus silica nanoparticles

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Incorporation of silica nanoparticles to PLGA electrospun fibers for osteogenic differentiation of human osteoblast-like cells

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Regenerative Biomaterials 2018年第4期5卷 229-238页

作者： Xing Yang Yuanyuan Li Xujie Liu Qianli Huang Ranran Zhang Qingling Feng State Key Laboratory of New Ceramics and Fine Processing School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China Department of Stomatology Shengli Oilfield Central HospitalDongying 257034China Graduate School at Shenzhen Tsinghua UniversityShenzhen 518055China State Key Laboratory of Powder Metallurgy Central South UniversityChangsha 410083China Key Laboratory of Advanced Materials of Ministry of Education of China School of Materials Science and EngineeringTsinghua UniversityBeijing 100084China

The development of bone tissue engineering scaffolds still remains a challenging field,although various biomaterials have been developed for this purpose.Electrospinning is a promising approach to fabricate nanofibers with an interconnected porous structure,which can support cell adhesion,guide cell proliferation and regulate cell differentiation.The aim of this study is to fabricate composite fibers composed of poly(lactic-co-glycolic acid)(PLGA)and silica nanoparticles(NPs)via electrospinning and investigate the effect of PLGA/SiO_(2)composite fibers on the cellular response of osteoblast-like cells(SaOS-2 cells).SEM and EDX analysis showed that silica NPs were homogenously dispersed in the composite fibers.The mechanical behavior of the fibers showed that silica NPs acted as reinforcements at concentrations of 2.5 and 5 mg/ml.The incorporation of silica NPs led to enhancement of cell attachment and spreading on PLGA/SiO_(2)composite fibers.SaOS-2 cells cultured on PLGA/SiO_(2)composite fibers exhibited increased alkaline phosphatase activity,collagen secretion and bone nodules formation.The bone nodules formation of SaOS-2 cells increased along with the amount of incorporated silica NPs.The present findings indicate that PLGA/SiO_(2)composite fibers can stimulate osteogenic differentiation of SaOS-2 cells and may be a promising candidate scaffold for bone tissue engineering.

关键词： composite fibers silica nanoparticles osteogenic differentiation bone tissue engineering

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Subchronic Oral Toxicity of silica nanoparticles and silica Microparticles in Rats

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Biomedical and Environmental Sciences 2018年第3期31卷 197-207页

作者： LIANG Chun Lai XIANG Qian CUI Wen Ming FANG Jin SUN Na Na ZHANG Xiao Peng LI Yong Ning YANG Hui YU Zhou JIA Xu Dong Key Laboratory of Food Safety Assessment of Ministry of Health China National Center for Food Safety Risk Assessment Beijing 100021 China Sichuan Province Medical Science Academy & Sichuan Provincial People's Hospital Chengdu 610072 Sichuan China

Objective To investigate the subchronic oral toxicity of silica nanoparticles（NPs） and silica microparticles（MPs） in rats and to compare the difference in toxicity between two particle sizes.Methods Sprague-Dawley rats were randomly divided into seven groups： the control group; the silica NPs low-, middle-, and high-dose groups; and the silica MPs low-, middle-, and high-dose groups [166.7,500, and 1,500 mg/（kg·bw·day）]. All rats were gavaged daily for 90 days, and deionized water was administered to the control group. Clinical observations were made daily, and body weights and food consumption were determined weekly. Blood samples were collected on day 91 for measurement of hematology and clinical biochemistry. Animals were euthanized for necropsy, and selected organs were weighed and fixed for histological examination. The tissue distribution of silicon in the blood, liver,kidneys, and testis were determined.Results There were no toxicologically significant changes in mortality, clinical signs, body weight,food consumption, necropsy findings, and organ weights. Differences between the silica groups and the control group in some hematological and clinical biochemical values and histopathological findings were not considered treatment related. The tissue distribution of silicon was comparable across all groups.Conclusion Our study demonstrated that neither silica NPs nor silica MPs induced toxicological effects after subchronic oral exposure in rats.

关键词： Subchronic toxicity silica nanoparticles silica microparticles Rats

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Immobilization of laccase from Myceliophthora thermophila on functionalized silica nanoparticles: Optimization and application in lindane degradation

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Chinese Journal of Chemical Engineering 2020年第4期28卷 1136-1144页

作者： Jelena Bebic Katarina Banjanac Marija Corović Ana Milivojevic Milica Simovic Aleksandar Marinkovic Dejan Bezbradica Directorate of Measures and Precious Metals Mike Alasa 1411000 BelgradeSerbia Innovation Centre of Faculty of Technology and Metallurgy University of BelgradeKarnegijeva 411000 BelgradeSerbia Department of Biochemical Engineering and Biotechnology Faculty of Technology and MetallurgyUniversity of BelgradeKarnegijeva 411000 BelgradeSerbia Department of Organic Chemistry Faculty of Technology and MetallurgyUniversity of BelgradeKarnegijeva 411000 BelgradeSerbia

This work is focused on immobilization of laccase from Myceliophthora thermophila expressed in Aspergillus oryzae(Novozym 51003?laccase)on amino modified fumed nano-silica(AFNS)and the possible use in bioremediation.Hereby,for the first time,factors affecting the immobilization of Novozym 51003?laccase on AFNS were investigated for defining the immobilization mechanism and optimizing the utilization of AFNS as support for laccase immobilization.The highest specific activity(13.1 IU·mg-1 proteins)was achieved at offered 160 mg per g of AFNS and for the same offered protein concentration the highest activity immobilization yield,reaching68.3%after the equilibrium time,at optimum pH 5.0,was obtained.Laccase immobilization occurs by adsorption as monolayer enzyme binding in 40 min,following pseudo-first-order kinetics.The possible use of obtained immobilized preparation was investigated in degradation of pesticide lindane.Within 24 h,lindane concentration was reduced to 56.8%of initial concentration and after seven repeated reuses it retained 70%of the original activity.

关键词： silica nanoparticles Laccase Enzyme immobilization Lindane Bioremediation

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One-step synthesis of amine-coated ultra-small mesoporous silica nanoparticles

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Nano Research 2020年第6期13卷 1592-1596页

作者： Mingyue Cui Christian Wiraja Lim Wei Qi Sharon Chew Wan Ting Deblin Jana Mengjia Zheng Xiao Hu Chenjie Xu Nanyang Environment&Water Research Institute Interdisciplinary Graduate ProgrammeNanyang Technological UniversitySingapore637141Singapore School of Chemical and Biomedical Engineering Nanyang Technological UniversitySingapore637457Singapore School of Materials Science and Engineering Nanyang Technological UniversitySingapore639798Singapore Division of Chemistry and Biological Chemistry School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore637371Singapore National Dental Centre of Singapore 5 Second Hospital AveSingapore168938Singapore Department of Biomedical Engineering City University of Hong Kong83 Tat Chee AvenueKowloonHong KongChina

silica nanoparticles have been studied extensively in biomedical field due to their high biocompatibility,controllable morphology and so on.They can be used both as the drug carrier and imaging vehicle.Here,an aminated ultra-small silica nanoparticle based system is developed with various functionalities.Multiple molecules including fluorophore,folic acid,and antibody are coupled to this system to achieve specific applications such as bacterial/cell labelling and recognition.

关键词： silica nanoparticles one-step synthesis surface modification bacterial&cell labelling

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Effect of silica nanoparticles/poly(vinylidene fluoride-hexafluoropropylene) coated layers on the performance of polypropylene separator for lithium-ion batteries

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Journal of Energy Chemistry 2014年第5期23卷 582-586页

作者： Hongyu Liu Zehui Dai Jun Xu Baohua Guo Xiangming He Department of Chemical Engineering Tsinghua University Institute of Nuclear and New Energy Technology Tsinghua University

In an effort to reduce thermal shrinkage and improve electrochemical performance of porous polypropylene （PP） separators for lithium-ion batteries, a new composite separator is developed by introducing ceramic coated layers on both sides of PP separator through a dip-coating process. The coated layers are comprised of heat-resistant and hydrophilic silica nanoparticles and polyvinylidene fluoride-hexafluoropropylene （PVDF-HFP） binders. Highly porous honeycomb structure is formed and the thickness of the layer is only about 700 nm. In comparison to the pristine PP separator, the composite separator shows significant reduction in thermal shrinkage and improvement in liquid electrolyte uptake and ionic conduction, which play an important role in improving cell performance such as discharge capacity, C-rate capability, cycle performance and coulombic efficiency.

关键词： composite separator silica nanoparticles dip-coating thermal shrinkage cell performance

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