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Status and challenges of global antimicrobial resistance control: A dialogue between Professors Yonghong Xiao and Takeshi Nishijima

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hLife 2024年第2期2卷 47-49页

作者： Yonghong Xiao Takeshi Nishijima State Key Laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated HospitalZhejiang University School of MedicineZhejiangChina Antimicrobial Resistance Essential Medicines and Health TechnologiesDivision of Health Systems and ServicesWHO Regional Office for the Western PacificManilaPhilippines

Antimicrobial resistance(AMR)is one of the top 10 public health threats,which is not only related to human health,but also closely related to animal health and environmental health.One health concept and framework are the core strategy to contain AMR.The World Health Organization(WHO)has already issued the Global Action Plan to contain AMR,which includes surveillance,education,stewardship,and innovation of new diagnostics and therapeutics.Western Asia–Pacific region is the most populous area of WHO,and also a region with severe AMR.Here,Dr.Nishijima,a professional officer of AMR control from WHO Regional Office for the Western Pacific discussed with Professor Yonghong Xiao(Zhejiang University)about the epidemiology,socioeconomic impact of AMR globally and in Western Asia–Pacific region(WPRO),and they talked the actions and strategies,achievements and shortcomings in the control of AMR during the past years,introduced the initiative of quadripartite One Health.The outstanding results of China in AMR containment were recognized.

关键词： resistance globally shortcomings

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China City Planning Review 2024年第2期33卷 90-91页

作者： Li Min 不详

Guidelines and Practices for Building Integrated Residential Communities Author:Beijing Municipal Institute of City Planning&Design Year:2022Publisher:China Architecture&Building Press ISBN:9787112275601(212 pages,in Chinese)As a basic unit of urban residents’life and urban governance,current residential communities generally have problems and shortcomings,such as unreasonable size,imperfect facility,insufficient space for public activities,poor property management covera.

关键词： shortcomings urban imperfect

A Comprehensive View on the Progress of Organoid Research with an Emphasis on its Relevance to Disease Characterization

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Biomedical and Environmental Sciences 2023年第10期36卷 959-971页

作者： Chandra KISHORE Vaishali Ji Saurav Mallik Ayan MUKHERJI Namrata TOMAR Soumen Kumar Pati LI Ai Min Sinthia Roy BANERJEE Soumadip GHOSH Raza Ali NAQVI University of California Irvine Medical CenterOrangeCA 92868USA Department of Botany J.D.Women’s CollegeBailey RoadPatna-800023India Harvard T.H.Chan School of Public Health BostonMA 02115USA Department of Information Technology Haldia Institute of TechnologyHaldiaWest BengalIndia Medical College of Wisconsin MilwaukeeWI 53226USA Department of Bioinformatics Maulana Abul Kalam Azad University of TechnologyNadiaWest BengalIndia Center for Precision Health School of Biomedical InformaticsThe University of Texas Health Science Center at HoustonHoustonTX 77030USA School of Computer Science and Engineering Xi’an University of TechnologyXi'an 710048ShaanxiChina Department of Information Technology Guru Nanak Institute of TechnologyKolkataWest BengalIndia Department of Computer Science and Engineering Sister Nivedita UniversityKolkataWest BengalIndia Center for Precision Health School of Biomedical InformaticsUniversity of IllinoisChicago60612USA

INTRODUCTION Organoids are primary tissue or stem cells derived cell aggregates that have the capacity for self-organization,self-renewal,and the capacity to mimic cellular and tissue level functions.Organoids can ove... 详细信息

关键词： functions. overcome shortcomings

Immunotherapy in hematologic malignancies:achievements,challenges and future prospects

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Signal Transduction and Targeted Therapy 2023年第9期8卷 4043-4081页

作者： Lu Tang Zhongpei Huang Heng Mei Yu Hu Institute of Hematology Union HospitalTongji Medical CollegeHuazhong University of Science and Technology430022 WuhanChina Hubei Clinical Medical Center of Cell Therapy for Neoplastic Disease 430022 WuhanChina Key Laboratory of Biological Targeted Therapy the Ministry of Education430022 WuhanChina Hubei Key Laboratory of Biological Targeted Therapy Union HospitalTongji Medical CollegeHuazhong University of Science and Technology430022 WuhanChina

The immune-cell origin of hematologic malignancies provides a unique avenue for the understanding of both the mechanisms of immune responsiveness and immune escape,which has accelerated the progress of immunotherapy.Several categories of immunotherapies have been developed and are being further evaluated in clinical trials for the treatment of blood cancers,including stem cell transplantation,immune checkpoint inhibitors,antigen-targeted antibodies,antibody-drug conjugates,tumor vaccines,and adoptive cell therapies.These immunotherapies have shown the potential to induce long-term remission in refractory or relapsed patients and have led to a paradigm shift in cancer treatment with great clinical success.Different immunotherapeutic approaches have their advantages but also shortcomings that need to be addressed.To provide clinicians with timely information on these revolutionary therapeutic approaches,the comprehensive review provides historical perspectives on the applications and clinical considerations of the immunotherapy.Here,we first outline the recent advances that have been made in the understanding of the various categories of immunotherapies in the treatment of hematologic malignancies.We further discuss the specific mechanisms of action,summarize the clinical trials and outcomes of immunotherapies in hematologic malignancies,as well as the adverse effects and toxicity management and then provide novel insights into challenges and future directions.

关键词： clinical treatment shortcomings

Silicon photonic devices for scalable quantum information applications

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Photonics Research 2022年第10期10卷 I0004-I0022页

作者： LANTIAN FENG MING ZHANG JIANWEI WANG XIAOQI ZHOU XIAOGANG QIANG GUANGCAN GUO XIFENG REN CAS Key Laboratory of Quantum Information University of Science and Technology of ChinaHefei 230026China CAS Center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of ChinaHefei 230026China Hefei National Laboratory University of Science and Technology of ChinaHefei 230088China State Key Laboratory for Modern Optical Instrumentation Centre for Optical and Electromagnetic ResearchZhejiang Provincial Key Laboratory for Sensing TechnologiesZhejiang UniversityZijingang CampusHangzhou 310058China State Key Laboratory for Mesoscopic Physics School of PhysicsPeking UniversityBeijing 100871China Frontiers Science Center for Nano-optoelectronics Collaborative Innovation Center of Quantum MatterPeking UniversityBejing 100871China School of Physics and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat-sen UniversityGuangzhou 510000China National Innovation Institute of Defense Technology AMSBeijing 100071China

With high integration density and excellent optical properties, silicon photonics is becoming a promising platform for complete integration and large-scale optical quantum information processing. Scalable quantum information applications need photon generation and detection to be integrated on the same chip, and we have seen that various devices on the silicon photonic chip have been developed for this goal. This paper reviews the relevant research results and state-of-the-art technologies on the silicon photonic chip for scalable quantum applications. Despite the shortcomings, the properties of some components have already met the requirements for further expansion. Furthermore, we point out the challenges ahead and future research directions for on-chip scalable quantum information applications.

关键词： expansion quantum shortcomings

Introduction to the Special Issue on Modeling of Heterogeneous Materials

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Computer Modeling in Engineering & Sciences 2023年第1期134卷 1-3页

作者： Lisheng Liu Xihua Chu Xinhua Yang Jianzhong Chen Qun Huang Hubei Key Laboratory of Theory and Application of Advanced Materials Mechanics Wuhan University of TechnologyWuhan430070China School of Civil Engineering Wuhan UniversityWuhan430070China School of Civil Engineering and Mechanics Huazhong University of Science and TechnologyWuhan430070China

In order to make up for the shortcomings of homogeneous materials and meet the needs of industry development,heterogeneous materials have been increasingly applied in aviation,automobile,bridge and other fields.Heterogeneous materials refer to advanced materials with non-uniform components.By adjusting the structure or composition of heterogeneous materials,their performance may change in a specific direction to adapt to different environments and achieve special functions.To achieve wide applications of homogeneous materials,it is very important to be able to predict the performance and material response of heterogeneous materials.Modeling method is a basic and important method to accomplish this task.Modeling methods for studying heterogeneous materials include finite element method(FEM),molecular dynamics(MD),peridynamics(PD)and so on.

关键词： materials. method shortcomings

APJTM streamlines content coverage and submission process to better support tropical medicine research

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Asian Pacific Journal of Tropical Medicine 2022年第6期15卷 239-240页

作者： Yan Lei Qiao Zhang Yin Pan Editorial Office of Asian Pacific Journal of Tropical Medicine Hainan Medical UniversityHaikou 571199China

Asian Pacific Journal of Tropical Medicine(APJTM)is a peer-reviewed open access monthly publication focusing on neglected tropical diseases and major diseases that are prevalent in the underdeveloped tropical regions.The Journal received an updated journal Impact Factor of 3.041 in the newly released 2021 Journal Citation Report,an increase of 148%over the past year.Among the 24 journals under the category of Tropical Medicine in the Science Citation Index-Expanded(SCIE),the Journal ranks 10/24(Q2).Although journal Impact Factor has several shortcomings and limitations,it is the most widely recognized indicator of journal prestige and impact[1].

关键词： journal shortcomings neglected

Rising to Challenges and Remedying shortcomings to Reach the Goal of Moderate Prosperity

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Qiu Shi 2020年第4期12卷 28-37页

作者：无 National Development and Reform Commission

Speaking at the fourth meeting of the Central Commission for Financial and Economic Affairs,General Secretary Xi Jinping said that China has already essentially achieved the objectives for building a moderately prosperous society in all respects,but stressed that although our efforts have yielded better results than anticipated,there still remain a number of weak links that need to be fixed.We must therefore go on the offensive,focusing our strength and working with greater intensity to ensure that these shortcomings are addressed quickly.

关键词： dying shortcomings prosperous

A knowledge-inherited learning for intelligent metasurface design and assembly

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Light(Science & Applications) 2023年第4期12卷 680-690页

作者： Yuetian Jia Chao Qian Zhixiang Fan Tong Cai Er-Ping Li Hongsheng Chen ZJU-UIUC Institute Interdisciplinary Center for Quantum InformationState Key Laboratory of Extreme Photonics and InstrumentationZhejiang UniversityHangzhou 310027China ZJU-Hangzhou Global Science and Technology Innovation Center Key Lab.of Advanced Micro/Nano Electronic Devices&Smart Systems of ZhejiangZhejiang UniversityHangzhou 310027China Jinhua Institute of Zhejiang University Zhejiang UniversityJinhua 321099China Air and Missile Defense College Air Force Engineering UniversityXi'an 710051China Shaoxing Institute of Zhejiang University zhejiang UniversityShaoxing321000China

Recent breakthroughs in deep learning have ushered in an essential tool for optics and photonics,recurring in various applications of material design,system optimization,and automation control.Deep learning-enabled on-demand metasurface design has been the subject of extensive expansion,as it can alleviate the time-consuming,low-efficiency,and experience-orientated shortcomings in conventional numerical simulations and physics-based methods.However,collecting samples and training neural networks are fundamentally confined to predefined individual metamaterials and tend to fail for large problem sizes.Inspired by object-oriented C++programming,we propose a knowledge-inherited paradigm for multi-object and shape-unbound metasurface inverse design.Each inherited neural network carries knowledge from the"parent"metasurface and then is freely assembled to construct the"offspring"metasurface;such a process is as simple as building a container-type house.We benchmark the paradigm by the free design of aperiodic and periodic metasurfaces,with accuracies that reach 86.7%.Furthermore,we present an intelligent origami metasurface to facilitate compatible and lightweight satellite communication facilities.Our work opens up a new avenue for automatic metasurface design and leverages the assemblability to broaden the adaptability of intelligent metadevices.

关键词： breakthrough consuming shortcomings