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Effects of microalgae chlorella species crude extracts on intestinal adaptation in experimental short bowel syndrome

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World Journal of Gastroenterology 2008年第28期14卷 4512-4517页

作者： Mustafa Kerem Bulent Salman Hatice Pasaoglu Abdulkadir Bedirli Murat Alper Hikmet Katircioglu Tahir Atici E Ferda Perin Ebru Ofluoglu General Surgery Department Faculty of MedicineGazi UniversityBesevler 06510AnkaraTurkey Clinic Biochemistry Department Faculty of MedicineGazi UniversityBesevler 06510AnkaraTurkey Pathology Department Diskapi Training and Education HospitalBesevler 06510AnkaraTurkey Biology Department Education FacultyGazi UniversityBesevler 06510AnkaraTurkey Medical Genetic Department Faculty of MedicineGazi UniversityBesevler 06510AnkaraTurkey

AIM： To evaluate the effects of chlorella crude extract （CCE） on intestinal adaptation in rats subjected to short bowel syndrome （SBS）. METHODS： Wistar rats weighing 230-260 g were used in the study. After anesthesia a 75% small bowel resection was performed. Rats were randomized and divided into groups. Control group （n = 10）： where 5% dextrose was given through a gastrostomy tube, Enteral nutrition （EN） group （n = 10）： Isocaloric and isonitrogen EN （Alitraq, Abbott, USA）, study group （n = 10）： CCE was administrated through a gastrostomy tube. Rats were sacrificed on the fifteenth pcstoperative day and blood and tissue samples were taken. Histopathologic evaluation, intestinal mucosal protein and DNA levels, intestinal proliferation and apoptosis were determined in intestinal tissues, and total protein, albumin and citrulline levels in blood were studied. RESULTS： In rats receiving CCE, villus lengthening, crypt depth, mucosal DNA and protein levels, intestinal proliferation, and serum citrulline, protein and albumin levels were found to be significantly higher than those in control group. Apoptosis in CCE treated rats was significantly reduced when compared to EN group rats. CONCLUSION： CCE has beneficial effects on intestinal adaptation in experimental SBS.

关键词： short-bowel syndrome Intestinal adaptation Chlorella Nutrition Microalgae

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Small bowel autotransplantation combined with pancreato-duodenectomy for enormous cavernous hemangioma of the small intestine mesentery

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Chinese Medical Journal 2008年第20期121卷 2110-2112页

作者： ZENG Yong WU Hong YANG Jia-yin Department of Hepatobiliary and Pancreatic Surgery West China Hospital Sichuan University Chengdu Sichuan 610041 China

Recent advances in transplantation techniques have allowed pancreatoduodenectomy, distal gastrectomy,hemicolectomy and small bowel autotransplantation to be the therapy of choice for enormous cavernous hemangioma of the small intestine mesentery. There have been a few case reports about small bowel autotransplantation combined with pancreatoduodenectomy for enormous mesenteric cavernous hemangioma of small intestine. The present surgical methods for enormous cavernous bemangioma of the small intestine mesentery mainly included tumor excision and/or small bowel resection. However, these therapies are not effective for those patients in whom the angiocavemoma has infiltrated the mesenteric artery or pancreas, and these patients often give up therapy. It is recognized that enormous cavernous hemangioma of the small intestine mesentery is a benign lesion, and patients may have an excellent prognosis after complete resection of the lesion.

关键词： small bowel autotransplantation cavernous hemangioma the small intestine mesentery short-bowel syndrome

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