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shape design of cerium oxide nanoparticles for enhancement of enzyme mimetic activity in therapeutic applications

Nano Research 2017年第1期10卷 199-217页

作者： Tamaki Naganuma Research Center for Functional Materials National Institute for Materials Science 1- I Namiki Tsukuba Ibaraki Japan

Cerium oxide nanoparticles （CONPs）, widely used in catalytic applications owing to their robust redox reaction, are now being considered in therapeutic applications based on their enzyme mimetic properties such as catalase and super oxide dismutase （SOD） mimetic activities. In therapeutic applications, the emerging demand for CONPs with low cytotoxicity, high cost efficiency, and high enzyme mimetic capability necessitates the exploration of alternative synthesis and effective material design. This study presents a room temperature aqueous synthesis for low-cost production of shape-selective CONPs without potentially harmful organic substances, and additionally, investigates cell viability and catalase and SOD mimetic activities. This synthesis, at room temperature, produced CONPs with particular planes： {111}/{100} nanopolyhedra, {100} nano/submicron cubes, and {111}/{100} nanorods that grew in [110] longitudinal direction. Enzymatic activity assays indicated that nanopolyhedra with a high concentration of Ce4＋ ions promoted catalase mimetic activity, while nanocubes and nanorods with high Ce3＋ ion concentrations enhanced SOD mimetic activity. This is the first study indicating that shape and facet configuration design of CONPs, coupled with the retention of dominant, specific Ce valence states, potentiates enzyme mimetic activities. These findings may be utilized for CONP design aimed at enhancing enzyme mimetic activities in therapeutic applications.

关键词： super oxide dismutase(SOD) and catalasemimetic activity shape and facetconfiguration Ce valence states room temperature aqueoussynthesis

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