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World Journal of Traditional Chinese Medicine 2024年第2期10卷 213-219页

作者： Elham Najafi Bahareh Babaei Hoolari Akbar Karimi Aliasghar Pilehvarian Department of Cellular Biology Genesis Evolution-Develoment Isfahan Payame Noor University IsfahanIran Department of Anatomy School of MedicineTehran University of Medical SciencesTehranIran Department of Biology Group Faculty Member of Isfahan Payame Noor UniversityIsfahanIran

Introduction: Dracaena cinnabari is considered a rich source of phytochemicals used widely in traditional medicine. In the present study, the effect of D. cinnabari hydraulic extract on the reproductive system of female rats was investigated. Methods: The samples were randomly divided into four groups(six samples in each group), including three treatment groups and one control group, and all samples were kept at the same conditions. Hydraulic extract of D. cinnabari and injected intraperitoneally daily for 10 days, while physiological serum was used for injection in to the control group. After 10 days of injection, estrogen and progesterone levels were measured by enzyme immunoassay technique. After dissection, the ovaries and uterine tissues were isolated for histological examination, and tissue changes were carefully examined. Results: The results revealed that the levels of estrogen and progesterone in experimental Groups 2 and 3 had a significant increase(P < 0.001). Regarding tissue changes, a significant increase was observed in epithelial thickness(P < 0.001), number of corpus luteum(P < 0.01), and Graafian follicle(P < 0.01) in doses of 100 and 150 mg/kg. Conclusions: Based on the results, it seems that D. cinnabari extract has an effect on the ovarian follicles.

关键词： Dracaena cinnabari herbal medicine ovarian tissues reproductive sex hormones

Brain-derived neurotrophic factor, sex hormones and cognitive decline in male patients with schizophrenia receiving continuous antipsychotic therapy

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World Journal of Psychiatry 2023年第12期13卷 995-1004页

作者： Jin Li Wen-Huan Xiao Fei Ye Xiao-Wei Tang Qiu-Fang Jia Xiao-Bin Zhang Department of Psychiatry The Affiliated Guangji Hospital of Soochow UniversitySuzhou 215137Jiangsu ProvinceChina Department of Psychiatry Affiliated Wutaishan Hospital of Medical College of Yangzhou UniversityYangzhou 225000Jiangsu ProvinceChina

BACKGROUND There are systematic differences in clinical features between women and men with schizophrenia(SCZ).The regulation of sex hormones may play a potential role in abnormal neurodevelopment in ***-derived neurotrophic factor(BDNF)and sex hormones have complex interacting actions that contribute to the etiology of *** To investigate the influence of BDNF and sex hormones on cognition and clinical symptomatology in chronic antipsychotic-treated male SCZ *** The serum levels of follicle-stimulating hormone,luteinizing hormone(LH),estradiol(E2),progesterone,testosterone(T),prolactin(PRL)and BDNF were compared between chronic antipsychotic-treated male(CATM)patients with SCZ(n=120)and healthy controls(n=120).The Positive and Negative Syndrome Scale was used to quantify SCZ symptoms,while neuropsychological tests were used to assess *** tests,such as the Digit Cancellation Test(DCT),Semantic Verbal Fluency(SVF),Spatial Span Test(SS),Paced Auditory Serial Addition Test(PASAT),Trail Making Task(TMT-A),and Block Design Test(BDT),were used to assess executive functions(BDT),attention(DCT,TMT-A),memory(SS,PASAT),and verbal proficiency(SVF).RESULTS Although E2 levels were significantly lower in the patient group compared to the healthy controls,T,PRL,and LH levels were all significantly ***,the analysis revealed that across the entire sample,there were positive correlations between E2 Levels and BDNF levels as well as BDNF levels and the digital cancellation *** CATM patients with SCZ,a significant correlation between the negative symptoms score and PRL levels was *** sex hormones and BDNF levels may also be linked to cognitive function in patients with chronic SCZ.

关键词： Brain-derived neurotrophic factor Clinical symptoms Cognitive function Schizophrenia sex hormones

A possible relationship between serum sex hormones and benign prostatic hyperplasia/Iower urinary tract symptoms in men who underwent transurethral prostate resection

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Asian Journal of Andrology 2017年第2期19卷 230-233页

作者： Yu Wu Hong Pan Wei-Ming Wang Ding Xu Liang Zhang Zheng-Qin Gu Qiang Bai un Qi e-Feng Huang Department of Urology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200092 China Department of Gynecology Xinhua Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200092 China Department of Assisted Reproduction Medicine International Peace Maternity and Child Health Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200030 China

In this study, we examined the relationship between sex hormone levels and lower urinary tract symptoms （LUTS） in men with benign prostatic hyperplasia （BPH） who underwent transurethral surgery. The study was conducted in 158 patients who came to our hospital for surgery. Clinical conditions were assessed by body mass index （BMI）, digital rectal examination, International Prostate Symptom Score （IPSS） and transrectal ultrasound （TRUS）. The levels of sex hormones （including total testosterone （TT）, estradiol （E2）, progesterone （P）, luteinizing hormone （LH）, follicle-stimulating hormone （FSH） and prolactin （PRL）） and prostate-specific antigen （PSA） were reviewed. Correlations were determined through statistical analysis. The mean age was 72.06 _＋ 8.68 years. The total IPSS was significantly associated with the TT level （r = -0.21, P = 0.01）. Other sex hormone levels were not correlated with total IPSS. However, some ratios such as E2/TT （r = 0.23, P = 0o00） and FSH/LH （r = -0.17, P = 0.04） were associated with total IPSS. Further analysis showed that the nocturia was associated with age （r = 0.16, P = 0.04）, BMI （r = 0.21, P = 0.01）, and TT （r = -0.19, P = 0.02）. Moreover, we divided the patients into two subgroups based on IPSS severity （〈20 or 〉20）. The mean TT level was in the normal range, but it was significantly related to the presence of severe LUTS. In summary, our study has shown that the severity of LUTS is associated with TT, EJTT and FSH/LH in men who underwent prostate surgery. Increasing nocturia was observed in lower testosterone patients. Additional larger studies are needed to elucidate the potential mechanisms.

关键词： aging benign prostatic hyperplasia lower urinary tract symptoms sex hormones testosterone

The relationship between sex hormones and extent of coronary artery disease in postmenopausal women

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Chinese Medical Journal 2007年第1期120卷 71-73页

作者： Odgerel Tumur HAN Jiang-li YANG Chi-sun MAO Jie-ming Department of Cardiology Peking University Third HospitalBeijing 100083 China Department of Obstetrics and Gynaecology Peking UniversityThird Hospital Beijing 100083 China

The prevalence of coronary artery disease （CAD） in women increases with menopause. Results from the studies on the role of endogenous sex hormones on CAD in postmenopausal women are conflicting. The present study evaluated the relationship between endogenous sex hormones and extent of CAD in postmenopausal women and the associations of sex hormones with CAD risk factors.

关键词： sex hormones coronary artery disease postmenopausal women

Role of sex hormones in gastrointestinal motility in pregnant and non-pregnant rats

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World Journal of Gastroenterology 2016年第25期22卷 5761-5768页

作者： Juliana Fernandes Matos Madileine Francely Americo Yuri Karen Sinzato Gustavo Tadeu Volpato Luciana Aparecida Corá Marcos Felipe Freitas Calabresi Ricardo Brandt Oliveira Debora Cristina Damasceno Jose Ricardo Arruda Miranda Sao Paulo State University BotucatuSP 18618-970Brazil Instituto de Ciencias Biologicas e da Saude Federal University of Mato GrossoBarra do GarcasMT 78600-000Brazil Universidade Estadual de Ciencias da Saude de Alagoas MaceioAL 57010-300Brazil Sao Paulo University Ribeirao PretoSP 14049-900Brazil

AIM: To correlate gastric contractility, gastrointestinal transit, and hormone levels in non-pregnant(estrous cycle) and pregnant rats using noninvasive techniques. METHODS: Female rats(n = 23) were randomly divided into(1) non-pregnant,(contractility, n =6; transit, n = 6); and(2) pregnant(contractility, n = 5; transit, n = 6). In each estrous cycle phase or at 0, 7, 14, and 20 d after the confirmation of pregnancy, gastrointestinal transit was recorded by AC biosusceptometry(ACB), and gastric contractility was recorded by ACB and electromyography. After each recording, blood samples were obtained for progesterone and estradiol determination. RESULTS: In the estrous cycle, despite fluctuations of sex hormone levels, no significant changes in gastrointestinal motility were observed. Days 7 and 14 of pregnancy were characterized by significant changes in the frequency of contractions(3.90 ± 0.42 cpm and 3.60 ± 0.36 cpm vs 4.33 ± 0.25 cpm) and gastric emptying(168 ± 17 min and 165 ± 15 min vs 113 ± 15 min) compared with day 0. On these same days, progesterone levels significantly increased compared with control(54.23 ± 15.14 ng/m L and 129.96 ± 30.52 ng/mL vs 13.25 ± 6.31 ng/mL). On day 14, we observed the highest level of progesterone and the lowest level of estradiol compared with day 0(44.3 ± 15.18 pg/mL vs 24.96 ± 5.96 pg/mL). CONCLUSION: Gastrointestinal motility was unaffected by the estrous cycle. In our data, high progesterone and low estradiol levels can be associated with decreased contraction frequency and slow gastric emptying.

关键词： Reproductive physiological process sex hormones Gastrointestinal motility Magnetic fields Gastric emptying

Role of sex hormones on CRH expressing-neurons in the human hypothalamic paraventricular nucleus

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Role of sex hormones on CRH expressing-neurons in the human ...

Research on the Effects of the Extract of Polygala fallax Hemsl on sex hormones andβ-EP in Perimenopausal Rat Models

中国神经科学学会第四次会员代表大会暨第七届全国学术会议

作者： Dick F.SWAAB Netherlands Institute for Neuroscience Meibergdreef 471105 BA Amsterdam ZOThe Netherlands

＜正＞Introduction:The activity of corticotropin-re leasing hormone（CRH） neurons in the hypothalamic paraventricular nucleus（PVN） forms the basis of the activity of the hypothalamo-pituitary-adrenal（HPA）-axis,which is the final common pathway for stress response and for a number of signs and symptoms in specific neurological and psychiatric disorders. A number of studies have pointed to the involvement of sex steroids in the regulation of the stress response and mood *** aimed at determining whether such regulations could be,at least partly,direct effects of sex steroids on the CRH-expressing neurons,via sex hormone ***,the gender difference in age-related number of CRH expressing-neurons and the role of sex hormones on it was also studied. Materials and Methods:Immunocytochemical study:Human hypothalami tissue was obtained from the Netherlands Brain *** monoclonal rat anti-CRH’PFU 83’ antibody and the polyclonal rabbit anti-estrogen receptor（ER）αantibody （MC-20） and polyclonal rabbit anti-androgen receptor（AR） antibody（ARIE） were used for double-labeling of CRH and ERα,and CRH and AR,respectively,in the hypothalamic PVN（virtually no ERβwere found）.CRH and ERαcolocolization was further studied in a depressed-patient-group,which was well-matched for the *** total numbers of CRH neurons in the PVN were also analyzed in 22 control subjects（11 males and 11 females） between the ages of 22 and 89 year, and of 10 subjects with abnormal sex hormone *** assay and co-transfection experiment:The human CRH promoter region was searched and a sequence strongly resembling an androgen responsive element（ARE） was found. Bandshift analysis of this potential ARE was ***,the function of this ARE was investigated by cotransfection of CRH-promoter reporter constructs with AR expression plasmid in SK-N-BE（2）c neuroblastoma ***: Significant correlations between the number of CRH cells and the number of CRH-ERαnuclear

关键词： CRH neurons the HPA axis sex hormones Mood disorders Aging sex difference

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Journal of Clinical and Nursing Research 2020年第3期4卷 120-124页

作者： Siyuan Yang Zhiyong Cao Jiabao Chen Gang Fang Faculty of Chinese Medicine Science Guangxi University of Chinese MedicineNanning 530200China Guangxi Zhuang Yao Medicine Center of Engineering and Technology Guangxi University of Chinese MedicineNanning 530200China

Objective:To study the effects of the ethnic medicine Polygala fallax Hemsl with Guangxi characteristics on the sex hormones andβ-EP in research objective perimenopausal rat ***:40 female SPF rats were randomly divided into 4 groups,including the normal,model,high-dose and lowdose *** of three groups except for the normal one were treated with perimenopausal modelling through the method of subcutaneous injection of compound 4-VCD for 15 consecutive *** of the normal and model group were normally fed without any *** of the high-dose and low-dose groups were administered by high-and low-dose intragastric administration of the extract of Polygala fallax *** to the menstrual cycle of the vaginal smear of the rat,each menstrual cycle is a course of treatment and 6 consecutive courses of treatment would be *** indexes of serum sex hormones(E2,FSH,LH)andβ-EP of rats in each group were observed after ***:After the treatment of 6 cycles,for the levels ofβ-EP and E2,the model group was lowest(Psex hormones andβ-EP in perimenopausal rat models and relieve the related symptoms with a certain dose-effect relationship.

关键词： Polygala fallax Hemsl Perimenopausal syndrome sex hormones β-EP

Effects of hormone replacement therapy on mood and sleep quality in menopausal women

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World Journal of Psychiatry 2024年第7期14卷 1087-1094页

作者： Qing Liu Zhen Huang Ping Xu Department of Gynecology Ganzhou Women’s and Children’s HospitalGanzhou 341000Jiangxi ProvinceChina

BACKGROUND Hormone replacement therapy is an effective treatment strategy for the management of symptoms in naturally menopausal ***,some patients report experiencing adverse *** To analyze the effects of hormone replacement therapy in menopausal female *** A total of 152 menopausal female patients admitted to the Gynecology Department of the Ganzhou Maternal and Child Health Hospital between January 2021 and December 2023 were divided into the observation group(n=76,conventional treatment+hormone replacement therapy)and the control group(n=76,conventional treatment only)via random *** improvement observed in the following items were compared between the groups:Kupperman menopausal index(KMI),emotional state[The Positive and Negative Affect Scale(PANAS)],sleep quality[Self-Rating Scale of Sleep(SRSS)],treatment effectiveness,and treatment *** The modified KMI and SRSS scores of the observation group were lower than those of the control group after three rounds of *** improvement in the PANAS score observed in the observation group was greater than that observed in the control group(P<0.05).The total treatment effectivity rate in the observation group was higher than that in the control group(86.84%vs 96.05%,χ2=4.121,P=0.042).The incidence rate of adverse reactions in the two groups was comparable(6.58%vs 9.21%,χ2=0.361,P=0.547).CONCLUSION Hormone replacement therapy effectively improved the clinical symptoms,actively channeled negative emotions,and improved the quality of sleep in menopausal patients,indicating its effectiveness and safety.

关键词： Hormone replacement therapy Menopause Women Mood states Sleep quality sex hormones

Environmental hypoxia:A threat to the gonadal development and reproduction in bony fishes

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Aquaculture and Fisheries 2022年第5期7卷 572-582页

作者： Nirmalendu Saha Debaprasad Koner Ritu Sharma Biochemical Adaptation Laboratory Department of ZoologyNorth-Eastern Hill UniversityShillong793022India

Vast stretches of open water bodies are gradually becoming hypoxic as a result of depletion of oxygen levels mainly due to various human anthropogenic *** problem of hypoxic stress on the fish population is likely to be exacerbated soon since the aquatic hypoxic environment is continuously spreading over vast areas *** recent years,various harmful effects of hypoxia to bony fishes have been reported,such as the restriction of energy-consuming metabolic processes,arrest of the growth of ovary and testes that are associated with endocrine disruption,loss of sperm and egg quality,inhibition of fertilization,hatching success,and also the reduction of larval survivability,thereby impairment of overall reproductive and developmental processes in *** of the brain-pituitary-gonad axis,and certain enzymes related to steroidogenesis and vitellogenesis in fish have also been reported as the primary targets for an endocrine malfunction during ***-sensitive downregulation of key genes responsible for controlling sex hormones’synthesis has been documented in certain bony ***,continuous exposure to hypoxia was reported to induce early expression of pro-apoptotic/tumor suppressor p53 genes,thereby causing immense cell death in hypoxic ***,the cellular responses to long-term hypoxia exposure and the degree of reproductive impairments in bony fishes are still not adequate to figure out the actual underlying *** present review intends to highlight the current knowledge about the detrimental impact of chronic/acute hypoxia at different stages of fish reproduction and the associated underlying molecular mechanisms.

关键词： sex hormones Endocrine disruption Gametogenesis Gonadal development Fish reproduction HPG-Axis

Body Composition, Gynecologic-Obstetric Variables, and Prolactin Levels in Patients with Breast Cancer

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Food and Nutrition Sciences 2023年第4期14卷 315-327页

作者： Luis-Alfredo Jiménez-Huerta María-del-Corazón-de-Jesús Huerta-Franco Ángel-Haziel Vargas-Huerta Francisco-Miguel Vargas-Luna María-Raquel Huerta-Franco Department of General Surgery Mexican Institute of Social Security HGZ 1 of Colima Colima Mexico Division of Social Sciences and Technology Center for Industrial Technical Education (CETI) Guadalajara Mexico Division of Engineering and Sciences Technological Institute of Higher Studies of Monterrey (ITESM) Monterrey Mexico Department of Physical Engineering University of Guanajuato Leon Mexico Department of Applied Sciences to Work University of Guanajuato Leon Mexico

Objective: The aim of this study was to determine body composition, gynecological, and obstetric data, sex hormones, and prolactin serum levels in pre- (PREW) and postmenopausal women (PMW) with breast cancer (BC) and compare them with a control group (CG) of healthy women. Methodology: BC patients without treatment or use of hormone replacement therapy, or hormonal birth control, and without data of metastasis were included. CG was matched for age, BMI, and menstrual cycle status. FSH, LH, E2, progesterone, testosterone, and prolactin (PRL) were measured using radioimmunoassay kits. Comparisons between BC and CG were made with “t” tests, and with the Mann-Whitney U-test;χ2 test was used to compare the qualitative variables between the groups. Results: Seventy-two patients with BC, and 74 CG women were evaluated. Both groups presented overweight data, BMI (kg/mt2) = 27.21 ± 5.51 vs. 28.40 ± 4.66, p = ns, for BC patients and CG, respectively. In PREW, the age at menarche was later in BC patients compared to the CG (13.3 ± 1.36 years vs. 12.41 ± 1.27 years, p = 0.005). The PMW with BC presented a higher age at menarche and menopause compared to the women of the CG (13.51 ± 1.48 vs. 12.91 ± 1.41, p = 0.09, and 49.03 ± 2.86 vs. 45.5 ± 8.78, p = 0.03, respectively). PRL levels were significantly higher in PMW with BC, in comparison with the CG;median and minimum and maximum values (min-max) were: 14.7 ng/mL (3.6 - 52.7) vs. 5.9 ng/mL (1.9 - 33.3), p = 0.005). A higher percentage of PMW with BC (26.0% vs. 7.1%, χ2 = 5.57, p = 0.01) presented hyperprolactinemia (PRL serum levels > 20 ng/mL), compared to the GC. Conclusions: The higher levels of PRL in PMW with BC compared with CG, suggest a proliferative effect of this hormone in the affected breast tissue. This study demonstrates the need to use biological markers such as PRL to determine the risk of BC in PMW.

关键词： Breast Cancer sex hormones Prolactin Postmenopausal Women