检索结果-南通市图书馆

Cross-sectional prevalence and pattern of non-anaemia severe malaria among 2–10 year olds in Sokoto in Northwestern Nigeria

引用

Frontiers of Medicine 2022年第6期16卷 969-974页

作者： Usman Nasir Nakakana Ridwan Muhammad Jega Aliyu Mamman Nauzo Yahya Mohammed Ismaila Mohammed Ahmed Medical Research Council The Gambia Unit at London School of Hygiene and Tropical MedicineFajara220The Gambia Department of Paediatrics Usmanu Danfodiyo University Teaching HospitalSokoto234Nigeria Department of Paediatrics Federal Medical CentreBirnin Kebbi234Nigeria Department of Microbiology Usmanu Danfodiyo UniversitySokoto234Nigeria Department of Community Medicine Usmanu Danfodiyo University Teaching HospitalSokoto234Nigeria

malaria is highly prevalent in Nigeria and accounts for approximately 40%of global malaria ***,most reports on severe malaria in Nigeria are from hospital-based studies without accurate information from communities;thus,malaria-related deaths in the community are left *** study aimed to describe the prevalence and pattern of severe malaria in a community in Northwestern Nigeria.A cross-sectional study was conducted among 2–10-year-old children in Sokoto,in August and December 2016,to determine the endemicity of malaria based on Plasmodium falciparum prevalence rate(PfPR2-10)and to describe the disease *** malaria was diagnosed according to the World Health Organisation *** were described using Stata version *** prevalence of non-anaemia severe malaria was higher than expected(2.6%),considering the endemicity pattern which was mesoendemic based on a PfPR2-10 of 34.8%.The mean age of children with severe malaria was 3.73 years,and the male—female ratio was 2:***,54.0%of the patients had hyperparasitaemia.A relatively high prevalence of non-anaemia severe malaria was found in *** finding suggests the need to identify and treat cases in the community using modifications of current strategies,particularly seasonal malaria chemoprophylaxis.

关键词： severe malaria nigeria malaria mortality PfPR2-10 intermediate malaria transmission

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Direct Cost of severe malaria Treatment Borne by the Families of Children Aged 0 - 5 Years at the Fana Reference Health Centre, Mali

引用

Health 2022年第12期14卷 1307-1320页

作者： Solomane Traore Abdourahamane Haidara Youssouf Samake Tegué Guindo Moussa Keita National Institute of Public Health (INSP) Bamako Mali Reference Health Centre (CSRéf) of Fana Koulikoro Mali

Introduction: malaria is both a disease caused by poverty and a cause of poverty. malaria is the leading cause of morbidity and mortality in Mali and is among the ten countries with the highest number of malaria cases and deaths. The objective was to estimate the direct economic cost borne by families in the treatment of severe malaria in children aged 0 - 5 years at the CSREF in Fana. Methodology: The study was cross-sectional, conducted from July 2017 to June 2018 with inclusion criteria and prospective data collection. The methodology was based on estimating the direct economic cost of severe malaria. Results: The sample consisted of 109 cases out of a total of 944 hospitalizations;59% of whom were boys and the 25 - 36 month age group was the most affected. The complications frequently encountered were severe anemia (50 cases) or 45.8%;convulsions (35 cases) or 32.1% and finally severe sepsis (8 cases) or 7.3%. The average direct cost was 25,324 Franc CFA (58.95 US Dollars) of which 66% represented the costs of medicines and consumables against 4% for the consultation. This cost was more than half the minimum wage in Mali. Conclusion: Despite the difficulties in estimating the cost in hospitals, the results obtained give us an estimate of the economic burden borne by families in the management of severe malaria cases among children in the district of Fana. Support is needed for parents in the fight against malaria in rural Mali.

关键词： severe malaria Direct Average Cost Fana District Health Center Mali

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

The Determinants of Fatal Outcomes during severe malaria in Children at the HKM University Teaching Hospital of Cotonou-Benin

引用

Open Journal of Pediatrics 2017年第4期7卷 245-253页

作者： Godonou Gratien Sagbo Florence Alihonou Marouf Jules Alao Yevedo Tohodjede Lutecia Zohoun Gilles Bognon Joseph Agossou Alphonse Noudamadjo Aida Orou-Guidou Pediatric Unit CNHU-HKMCotonouBenin Lagoon Mother and Child Hospital CotonouBenin Hospital of Porto-Novo Porto-NovoBenin Pediatric Unit CHU-BorgouParakouBenin

Introduction: malaria particularly affects children in sub-Saharan African countries. This study aimed to investigate the factors associated with death in cases of severe childhood malaria to better understand the determinants of death in these children. Patients and Methods: This cohort, descriptive and analytical study was conducted from April 1 to August 15, 2015, at the CNHU-HKM pediatric clinic in Cotonou. Recruitment was exhaustive for all patients under 15 years of age who were admitted for severe malaria, as confirmed by thick smear microscopy. Results: Among the 1774 admitted patients, 449 had severe malaria caused by Plasmodium falciparum (i.e., a hospital frequency of 25.31%). The age group most affected consisted of children younger than 60 months of age (73%);female predominance was noted. The lethality rate of malaria was 13.1% (n = 59). The factors associated with death were coma (p = 0.032), poor convulsive status epilepticus (p = 0.08) and bacterial co-infection by gram negative bacteria (p = 0.021) with respectively correlations coefficient of 0.003, 3.940 and 2.424. Conclusion: Reduction of the malaria mortality rates in Benin hospitals will depend on appropriate management of poor prognostic factors, such as coma, bacterial co-infection and convulsive illness.

关键词： Children severe malaria Lethality Neurological Disorders Bacterial Infection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Quality of Management of severe malaria Cases in Children under Five: A Case of Four Health Facilities in the Littoral Department in Benin

引用

Advances in Infectious Diseases 2020年第3期10卷 163-175页

作者： Gloria Ayivi-Vinz Ghislain E. Sopoh Charles Sossa Chabi Olaniran Alphonse Biaou Abdou-Rahim Ouro-Koura Michel Makoutodé Edgar-Marius Ouendo Institut Régional de Santé Publique Comlan Alfred Quenum Université d’Abomey Calavi Bénin Centre de Formation en Santé Publique (CFSP) Lomé Togo

Background: Benin republic is a sub-Saharan African country endemic to malaria caused by Plasmodium falciparum. To reduce the death rate due to this scourge, it is essential to ensure quality care, especially for children under five years who are the most vulnerable. The main objective of this study is to assess the quality of severe malaria case management in patients under five years. Methods: Descriptive and analytical cross-sectional study

关键词： severe malaria Case Management Protocol Observance Quality of Care Benin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Progression of Frequency and Lethality of severe malaria from 2017 to 2020 in the Pediatric Unit of CHUD-Parakou (Benin)

引用

Open Journal of Pediatrics 2021年第4期11卷 551-558页

作者： Honorat Francis Lalya Alphonse Noudamadjo Falilatou Agbeille-Mohamed Mèdétinmè Gérard Kpanidja Zinsou Rodrigue Ahodègnon Julien Didier Adédémy Joseph Agossou Mother and Child Department Faculty of Health Sciences University of Abomey-Calavi Godomey Benin Mother and Child Department Faculty of Medicine University of Parakou Parakou Benin

Background: The latest WHO report shows a decline in the performances achieved concerning the fight against malaria since 2017. This research work aimed to investigate the progression of frequency and lethality due to severe malaria from 2017 to 2020 in the pediatric unit of the Borgou University Teaching Hospital in Parakou (CHUD-Parakou). Patients and Methods: This research work is a descriptive and analytical case-control study focused on all the children aged 1 month and more, hospitalized in the pediatric unit of CHUD-Parakou from January 1, 2017, to December 31, 2020. Recruitment criteria were the following: be admitted to hospital during the period specified above;have a usable medical record containing the diagnosis and type of discharge, and the findings of thick smear examination and/or of a rapid diagnostic test. Sampling was complete and takes into account all the medical records of children meeting the inclusion criteria. Epi Info 7.2.2 was the software used to perform data processing. Results: The frequencies of severe malaria in the unit were estimated at 19.89%, 22.65%, 29.65% and 27.51% respectively in 2017, 2018, 2019 and 2020. Lethality rates varied from 7.76% to 8.68 from 2017 through 2020. The death risk associated with severe malaria was 3.08 times higher in children suffering from severe acute u

关键词： severe malaria Children Frequency Lethality Benin

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Post-Quinine Bilious Hemoglobin Fever in an 8-Year-Old Child Monitored for severe malaria at the Yalosase Health Center, Isangi, DR Congo

引用

Advances in Infectious Diseases 2021年第1期11卷 1-5页

作者： Dieudonné Lobela Bumba Issa Yakusu Issa Bruce Wembolua Shinga Muyobela Kampunzu Gilbert Bokungu Isongibi Francy Baelongandi Folo Jacques Ossinga Bassandja Higher Institute of Medical Techniques of Yangambi Yangambi Democratic Republic of Congo Yalosase Health Center Rural Health Zone of Isangi Isangi Democratic Republic of Congo Lomboto Reference Health Center Isangi Rural Health Zone Isangi Democratic Republic of Congo Department of Internal Medicine Faculty of Medicine and Pharmacy University of Kisangani Kisangani Democratic Republic of Congo Infectious and Tropical Diseases Department National University Hospital of Fann Dakar Senegal Department of Pediatrics Faculty of Medicine and Pharmacy University of Kisangani Kisangani Democratic Republic of Congo Provincial Health Division Tshopo Democratic Republic of Congo

It has been known since March 2013 that Artesunate is considered the gold standard treatment for severe malaria [1] [2] [3]. However, in our regions, the drug of choice available to treat patients with severe malaria remains quinine until today. However, frequent and sequential use of quinine is associated with the occurrence of hemoglobinuria [2]. We report a probable case of bilious hemoglobin fever (BHF) in an 8-year-old child. This was an 8-year-old child with a history of frequent and recent treatment with quinine, received in consultation for coca-cola urine emission with rapid diagnostic test (RDT) positive. In search of a particular terrain, the retroviral and syphilitic serologies were negative. Considering the context, the diagnosis of post-quinine hemoglobin bilious fever (BHF) was retained and the patient had progressed well after administration of artemisinin and its derivatives. The child was followed, on an outpatient basis, without any sequelae. It would therefore be prudent for the time being to avoid them in prophylaxis and self-medication.

关键词： Bilious Hemoglobin Fever severe malaria Quinine Isangi

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

severe Childhood malaria in Two Health Districts of Cuvette-Congo

引用

Open Journal of Pediatrics 2022年第3期12卷 582-593页

作者： Moyen Engoba Prudencia Joachinelle Malouono Moukassa Géril Sekangue Obili Lynda Tchidjo Ngamo Georges Marius Moyen Jean-Louis Nkoua Faculty of Health Sciences University Marien Ngouabi Brazzaville Congo Department of Intensive Care Pediatrics University Hospital of Brazzaville Congo

Introduction: malaria is a public health problem. severe forms of malaria are linked to high mortality. Objective: To establish the cartography of severe malaria in two health districts in Cuvette-Congo. Methodology: An analytical and cross-sectional study was conducted from January to September 2019 in two health districts of Cuvette-Congo. Children aged three months to 17 years diagnosed with severe malaria were included. The epidemiological, clinical and paraclinical variables were analyzed. The statistical tests used were Pearson’s chi2 and the corrected Yates test. Results: Out of 806 children hospitalized, 277 had severe malaria (34.4%). There were 144 boys and 133 girls, an average of 60.9 months old. Anemia n = 247 (89.2%), repeated seizures n = 66 (23.8%), were the signs of severity observed. The clinical forms were isolated (n = 237) in 85.6% and associated (n = 40) in 14.4%, including 210 (88.6%) anemic form and 27 (11.4%) neurological form. The death occurred in seven cases (2.5%). The predictors of death were coma, jaundice, hypoglycemia, thrombocytopenia, hepatomegaly, undernutrition, dehydration and delayed consultation. Conclusion: The large number of cases of severe malaria in Cuvette, often in children under five years old, requires that the national program for control of malaria be strengthened by insisting on a wide distribution of long-lasting insecticide-treated mosquito nets.

关键词： severe malaria Child Cuvette-Congo

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acquisition of naturally acquired antibody response to Plasmodium falciparum erythrocyte membrane protein 1-DBLα and differential regulation of IgG subclasses in severe and uncomplicated malaria

引用

Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1055-1061页

作者： Natharinee Horata Kiattawee Choowongkomon Siriluk Ratanabunyong Jarinee Tongshoob Srisin Khusmith Faculty of Medical Technology Huachiew Chalermprakiet University18/18 Bangna Trad km.18 RoadSamuthprakran10540Thailand Department of Biochemistry Faculty of ScienceKasetsart UniversityBangkok10900Thailand Department of Microbiology and Immunology Faculty of Tropical MedicineMahidol University420/6 Rajvithi RoadBangkok 10400Thailand Center for Emerging and Neglected Infectious Diseases Mahidol UniversityBangkokThailand

Objectives: To explore whether individuals infected with Plasmodium falciparum(P. falciparum) develop antibodies directed against Pf EMP1-DBLa, and to assess their IgG subclass distribution in severe and uncomplicated ***: The anti-PfDBLα IgG and their IgG subclass distributions in plasma of severe(SM) and uncomplicated malaria(UCM) were assessed by enzyme-linked immunoabsorbent assay. The antibody profiles to P. falciparum blood stage antigens were evaluated. CD36 binding ability was determined by static receptor-binding *** formation was performed by staining with acridine ***: Significantly higher number of UCM(86.48%) than SM(57.78%) plasma contained total acquisition of specific IgG to P. falciparum antigens(P = 0.000). Similar manners were seen in response to P. falciparum DBLa with significant difference(UCM,59.46% vs SM, 40.00%; P = 0.014). Anti-PfDBLα-IgG1 and-IgG3 were the predominant subclasses. Similar percentage of UCM(31.82%) and SM(33.33%) plasma contained only IgG1, while 13.64% of UCM and 27.78% of SM plasma contained only IgG3. AntiPfDBLα-IgG1 coexpressed with more than one subclass was noted(UCM, 27.27%; SM,16.67%). Obviously, IgG1 coexpressed with IgG3(9.09%) was observed in only UCM plasma. IgG1 was coexpressed with IgG2 in UCM(9.09%) and SM(11.11%) plasma,while IgG1 was coexpressed with IgG4 only in UCM plasma(4.55%). IgG subclasses to P. falciparum antigens were distributed in a similar manner. Only the levels of IgG1, but not IgG3 were significantly higher in UCM than in ***: These data suggest that individuals infected with P. falciparum can develop the anti-Pf EMP1 antibodies with the major contribution of specific IgG subclasses. The balance and the levels of anti-PfDBLα IgG subclasses play a crucial role in antibody mediated protection against severe malaria.

关键词： Plasmodium falciparum PfEMP1-DBLα Antibody severe malaria Uncomplicated malaria

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of the Covid-19 Pandemic on severe Childhood malaria at the University Hospital of Brazzaville

引用

Open Journal of Pediatrics 2021年第2期11卷 301-312页

作者： Moyen Engoba Arquevia Nature Ofamalekou Gnakingue Ben Borgea Nianga Carel Ervane Goma Armel Landry Batchi-Bouyou Annie Rachelle Okoko Georges Marius Moyen Faculty of Health Sciences Marien Ngouabi University Brazzaville Congo Pediatric Intensive Care Service University Hospital of Brazzaville Brazzaville Congo Program and Project Coordination Unit Ministry of Health and Population Brazzaville Congo

Introduction: malaria management has been a source of concern for health systems since the advent of the Covid-19 pandemic. Objective: To assess the impact of the Covid-19 pandemic on severe childhood malaria in Brazz... 详细信息

Introduction: Malaria management has been a source of concern for health systems since the advent of the Covid-19 pandemic. Objective: To assess the impact of the Covid-19 pandemic on severe childhood malaria in Brazzaville. Material and Method: A quasi-experimental intervention/non-intervention study was carried out between March and October 2020 in the pediatric departments of the Brazzaville University Hospital. Children aged three months to 15 years hospitalized were the target population. Two groups were formed: the “intervention” group, that of children hospitalized between March and October 2020 and the “control” group that of those hospitalized between January and August 2015. The study variables were epidemiological, clinical, biological and therapeutic. Chi-square and T-Student tests were used. The impact of the intervention was assessed by the absolute risk difference. Results: Of 1392 children hospitalized, 199 (14.6%) had severe malaria with an average age of 6.94 years. These were children under 5 years old n = 95 (47.7%) of low socioeconomic level n = 145 (72.9%) seen on average after 4.6 +/? 2.4 days. Repeated convuls

关键词： Impact Covid-19 severe malaria Children Brazzaville

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Diagnosis and management of malaria in the intensive care unit

引用

Journal of Intensive Medicine 2024年第1期4卷 3-15页

作者： George Akafity Nicholas Kumi Joyce Ashong Department of Research Monitoringand EvaluationCape Coast Teaching HospitalCape CoastGhana Intensive Care Unit Department of Critical Care and AnesthesiaCape Coast Teaching HospitalCape Coast Department of Paediatrics and Child Health Cape Coast Teaching HospitalCape CoastGhana

malaria is responsible for approximately three-quarters of a million deaths in humans globally each *** of the morbidity and mortality reported are from Sub-Saharan Africa and Asia,where the disease is *** non-endemic areas,malaria is the most common cause of imported infection and is associated with significant mortality despite recent advancements and investments in elimination *** malaria often requires intensive care unit admission and can be complicated by cerebral malaria,respiratory distress,acute kidney injury,bleeding complications,and *** care management includes prompt diagnosis and early initiation of effective antimalarial therapy,recognition of complications,and appropriate supportive ***,the lack of diagnostic capacities due to limited advances in equipment,personnel,and infrastructure presents a challenge to the effective diagnosis and management of *** article reviews the clinical classification,diagnosis,and management of malaria as relevant to critical care clinicians,highlighting the role of diagnostic capacity,treatment options,and supportive care.

关键词： malaria Intensive care unit severe malaria Antimicrobial resistance Antimalarials Artemisinin-based combination therapy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：