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Prevalence of severe fever with thrombocytopenia syndrome virus in animals in Henan Province, China

Infectious Diseases of Poverty 2019年第3期8卷 82-87页

作者： Xue-Yong Huang Yan-Hua Du Hai-Feng Wang Ai-Guo You Yi Li Jia Su Yi-Fei Nie Hong-Xia Ma Bian-Li Xu Henan Center for Disease Control and Prevention ZhengzhouChina Henan Key Laboratory of Pathogenic Microorganisms ZhengzhouChina

severe fever with thrombocytopenia syndrome(SFTS)is an emerging infectious disease caused by severe fever with thrombocytopenia syndrome virus(SFTSV).SFTSV has been found in humans,ticks and animals,and SFTS has high mortality and increasing prevalence in East *** the study,the samples(heart,liver,lung,kidney,spleen,brain tissue and serum)were collected from 374 domestic animals and 241 wild animals in Pingqiao District and Xinxian County of Xinyang in Henan Province,China.275(44.72%,275/615)animals were positive for anti-SFTSV antibodies,the anti-SFTSV antibodies positive ratios of domestic and wild animals were 43.58%(163/374)and 46.47%(112/241),*** was no significant difference in domestic and wild animals,but significant differences were detected among different species of animals(x^2=112.59,P<0.0001).Among 615 animals,105(17.07%,105/615)animals were positive for SFTSV RNA,and only one SFTSV strain was isolated from heart tissue of a yellow *** phylogenetic analysis shows that the sequence from animals belonged to the same group with viral sequences obtained from *** animals maybe play a reservoir host in maintaining the life cycle of SFTSV in nature.

关键词： severe fever with thrombocytopenia syndrome virus Epidemiological investigation Animal Reservoir host

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Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antivirai platform

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Journal of Molecular Cell Biology 2014年第4期8卷 324-337页

作者： Yun-Jia Ning Manli Wang Maping Deng Shu Shen Wei Liu Wu-Chun Cao Fei Deng Yan-Yi Wang Zhihong Hu Hualin Wang State Key Laboratory of Virology Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China State Key Laboratory of Pathogen and Biosecurity Beijing Institute of Microbiology and Epidemiology Beijing 100071 China

For antiviral signaling mediated by retinoic acid-inducible gene I （RiG-I）-like receptors （RLRs）, the recruitment of cytosoUc RLRs and downstream molecules （such as TBK1 and IKKε） to mitochondriaL platform is a central event that facilitates the establishment of host antiviral state. Here, we present an example of viral targeting for immune evasion through spatial isolation of TBK1/IKKε from mitochond riai antiviral platform, which was employed by severe fever with thrombocytopenia syndrome virus （SFTSV）, a deadly bunyavirus emerging recently. We showed that SFTSV nonstructural protein NSs functions as the interferon （IFN） antagonist, mainly via suppressing TBK1/IKKε-IRF3 signaling. NSs mediates the formation of cytoplasmic inclusion bodies （IBs）, and the blockage of IB formation impairs IFN-inhibiting activity of NSs. We next demonstrate that I Bs are utilized to compartmentalize TBK1/I KKε. The compartmentalization results in spatial isolation of the kinases from mitochondria, and deprived TBK1/IKKε may participate in antiviral complex assembly, leadingto the blockage of lFN ind uction. This study proposes a new role of viral I Bs as virus-built＇jail＇ for imprisoning cellular factors and presents a novel and likely common mechanism of viral immune evasion through spatial isolation of critical signaling molecules from the mitochondrial antiviral platform.

关键词： innate immunity immune evasion severe fever with thrombocytopenia syndrome virus inclusion bodies TBK1/IKKε spatial isolation

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