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Current Medical Science 2024年第3期44卷 494-502页

作者： Jiang-hui LI Xue-yao MA Yun YI Lu-rao LI Zhi-yong XU Ying CHANG Department of Gastroenterology Zhongnan Hospital of Wuhan UniversityWuhan430071China Hubei Clinical Center and Key Laboratory of Intestinal and Colorectal Diseases Wuhan430071China Endoscopy Center The People’s Hospital of YingshanHuanggang438799China

Objective ferritin,initially acting as an iron-storage protein,was found to be associated with metabolic *** study was designed to investigate the association between serum ferritin and metabolic-associated fatty liver disease(MAFLD)using data from the National Health and Nutrition Examination Survey(NHANES)of the United State of *** A cross-sectional study was conducted,enrolling a total of 2145 participants from the NHANES in the 2017–2018 *** steatosis and liver fibrosis were assessed by ultrasound images and several non-invasive *** regression analysis was conducted to determine the associations between serum ferritin concentration and MAFLD and liver *** The analysis revealed that participants with higher serum ferritin levels(Q3 and Q4 groups)had a higher prevalence of MAFLD than those with the lowest serum ferritin levels[Q3 vs.Q1:OR=2.17(1.33,3.53),Pserum ferritin levels(Q4 group)displayed a higher prevalence of liver fibrosis[Q4 vs.Q1:OR=2.59(1.19,5.62),Pserum ferritin levels are associated with a higher prevalence of MAFLD and advanced liver fibrosis in *** serum ferritin levels combined with diabetes are important risk factors for liver fibrosis.

关键词： serum ferritin liver fibrosis metabolic-associated fatty liver disease National Health and Nutrition Examination Survey

The validity of serum ferritin levels in predicting cardiovascular events of metabolic dysfunction-associated steatotic liver disease patients may need more consideration

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 755-756页

作者： Jie Yang Qing Liu Jie Li Chao Sun Department of Gastroenterology Tianjin Medical University General Hospital Airport HospitalTianjinChina Department of Gastroenterology and Hepatology Tianjin Medical University General HospitalTianjinChina Department of Infectious Diseases Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingChina

We read with great interest the informative study by Armandi et al.,which shed light on the potential role of serum ferritin in predicting the long-term prognosis of patients with metabolic dysfunction-associated steatotic liver disease(1).However,there remain certain facets requiring in-depth investigation and *** of all,the study found that integrating stepwise increased ferritin thresholds(215.5 and 272µg/L)into predictive models can improve the performance of fibrosis-4(FIB-4)and Non-Alcoholic Fatty Liver Disease Fibrosis Score(NFS)in the longitudinal risk assessment of liver-related events and overall ***,it has been suggested that metabolic hyperferritinaemia(MHF)appears to exhibit a male predominance(2,3).Since the study primarily comprised male participants(65%),it raises the query of whether the ferritin threshold based on the entire population can accurately predict risks within female ***,a sex-specific analysis is warranted to ensure a more precise evaluation.

关键词： Metabolic dysfunction-associated steatotic liver disease(MASLD) serum ferritin cardiovascular events

Relationship between serum ferritin and hemoglobin levels determined by cardiac and hepatic T2 MRI in beta-thalassemia intermedia and major patients

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Frontiers in Biology 2017年第4期12卷 311-315页

作者： Bijan Keikhaei Pejman Slehi-fard Seyed-Ali Nojottmi Abbas Khosravi Thalassemia and Hemoglobinopathies Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Microbiology Research Center Pasteur Institute oflran Tehran Iran Department of Hematology Allied Medical School Tehran University of Medical Sciences Tehran Iran

BACKGROUND： Thalassemia major is one of the most common hereditary disorders, and it causes ineffective hematopoiesis in the body through disarrangement of the hemoglobin synthesis balance. Regular blood transfusions cause complications of iron overload in the body in these patients. Tissue iron status can be determined by measuring serum and liver biopsy ferritin levels and by T2＊ MRI. This study assessed the relationship between serum ferritin and hemoglobin by T2＊ MRI of the heart and liver. METHOD： This cross-sectional descriptive study was carried out on patients with beta-thalassemia intermedia and major who visited the Center for Thalassemia and Hemoglobinopathies at Shafa Hospital, Ahwaz, between 2014 and 2015. All patients were receiving regular blood transfusions every 2-4 weeks. Pearson＇s correlation test was used to assess serum ferritin and T2＊ values from heart and liver MRI. RESULTS： A total of 260 patients （mean age is 23-year-old） were enrolled in the study. The incidence of iron overload in the liver and heart was 83% and 39%, respectively. serum ferritin levels showed a very strong inverse correlation with T2＊ values on heart （r = -3.54, p 〈 0.0001） and liver （r = -3.03, p 〈 0.0001） MRI. Additionally, a meaningful interaction was observed between the T2＊ values from liver and heart MRI （r = 0.29, p 〈 0.0001）. CONCLUSION： serum ferritin is strongly and inversely correlated with T2＊ values of MRI of the liver and heart in patients with thalassemia. Therefore, T2＊ MRI can be used to assess tissue iron levels with very high accuracy.

关键词： serum ferritin thalassemia T2* MRI liver heart iron overload

Study on The Method of Quantitative Analysis of serum ferritin and Soluble Transferrin Receptor with Protein Microarray Technology

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Biomedical and Environmental Sciences 2012年第4期25卷 430-439页

作者： YIN Ji Yong SUN Jing HUANG Jian LI Wen Xian HUO Jun Sheng Institute for Nutrition and Food Safety Chinese Center for Disease Control and PreventionBeijing 100050China

Objective To establish and evaluate a protein serum ferritin （SF） and soluble transferrin receptor microarray method for combined measurement of （sTfR）. Methods Microarrayer was used to print both anti-SF antibodies I and anti-sTfR antibodies I on each protein microarray. Anti-SF antibodies II and anti-sTfR antibodies II were used as detection antibodies and goat antibodies coupled to Cy3 were used as antibodies Ill. The detection conditions of the quantitative analysis method for simultaneous measurement of SF and sTfR with protein microarray were optimized and evaluated. The protein microarray was compared with commercially available traditional tests with 26 serum samples. Results By comparison experiment, mouse monoclonal antibodies were chosen as the probes and contact printing was chosen as the printing method. The concentrations of SF and sTfR probes were 0.5 mg/mL and 0.5 mg/mL respectively, while those of SF and sTfR detection antibodies were 5 μg/mL and 0.36 μg/mL respectively. Intra- and inter-assay variability was between 3.26% and 18.38% for all tests. The regression coefficients comparing protein microarray with traditional test assays were better than 0.81 for SF and sTfR. Conclusion The present study has established a protein microarray method for combined measurement of SF and sTfR.

关键词： Protein microarray Optimization Combined measurement conditions serum ferritin Soluble transferrin receptor.

Study on the Correlation between the Expression of serum ferritin and Gestational Diabetes Mellitus

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Open Journal of Obstetrics and Gynecology 2020年第8期10卷 1135-1140页

作者： Weiwei Li Zhijuan Sun Department of Clinical Laboratory Qingdao Sanatorium of Shandong Province Qingdao China Department of Clinical Laboratory Qingdao No. 9 People’s Hospital Qingdao China

Objective: To explore the relationship between serum ferritin (SF) and gestational diabetes mellitus (GDM), for providing new ideas to the prevention and treatment of GDM. Methods: All the pregnant women were selected in Yinan Maternal and Child Health-Care Hospital from December, 2015 to March, 2018 when they were having routine prenatal examination, According to the diagnostic criteria of GDM, 72 patients with GDM were selected as the case group and 72 normal pregnant women were randomly selected as the control group. Fasting venous blood was drawn from all subjects during the first trimester of pregnancy (11-13 weeks) and the second trimester of pregnancy (24-28 weeks). Fasting plasma glucose was measured by glucose oxidase assay and the expression level of SF was determined by electrochemical method. The application value of SF in GDM diagnosis was evaluated by ROC curve. Results:

关键词： serum ferritin Gestational Diabetes Mellitus Correlation

Analysis of serum ferritin Level and Its Clinical Value in Advanced Gastric Cancer

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Journal of Biosciences and Medicines 2022年第1期10卷 1-6页

作者： Xiaoyu Huang Qi Wang Qiwei Chen Jingya Ye Gong Chen Qibing Wu Department of Radiotherapy The First Affiliated Hospital of Anhui Medical University Hefei China

Objective: To investigate the concentration and clinical significance of serum ferritin (SF) in patients diagnosed with advanced gastric cancer before and after treatment. Methods: Forty patients with advanced gastric cancer diagnosed by cytology or pathology in our hospital were selected, including 25 males and 15 females, aged from 48 to 85 years, and the median age was 61.0 years. 40 healthy volunteers matched with age and education were selected as the control group. In order to study the changes of SF level in the treatment of advanced gastric cancer, we divided the patients into effective group (efficacy evaluation as partial remission or complete remission), ineffective group (efficacy evaluation as no remission) and recurrence group according to the efficacy after treatment. Then the difference of SF level between different groups and the relationship between SF level and curative effect were analyzed. There was no significant difference in gender and age among all groups. Results: The SF levels in the newly diagnosed group, stage III patient group and stage IV patient group were significantly higher than those in the control group. The level of SF in stage IV patients was significantly higher than that in stage III patients. There were significant differences in SF level between the effective treatment group, the newly diagnosed group and the ineffective treatment group, but there was no significant difference in SF level between the newly diagnosed group and the ineffective treatment group. Conclusion: SF level has a certain value in the auxiliary diagnosis of gastric cancer, and it also has a certain guiding significance for the evaluation of curative effect and prognosis after treatment.

关键词： Gastric Cancer serum ferritin Diagnosis Curative Effect

Does free thyroxine levels influence the relationship between maternal serum ferritin and gestational diabetes mellitus in early pregnancy?

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Does free thyroxine levels influence the relationship betwee...

The Potential Clinical Significance of the serum Iron and ferritin Status in Lung Cancer Patients

2019长三角围产医学学术会议暨浙江省围产医学学术大会

作者： Gu Yanqiong Su Xiujuan li yuhong tang yuping baoyirong Ying Hao Shanghai First Maternity and Infant Hospital Tongji University School of Medicine

Background: Gestational diabetes mellitus(GDM) is one of the most common pregnancy complications, with approximately 1% to 14% of pregnancies affected every year around the world, while its etiology is still unclear. The objective of this study was to estimate combined effect of serum ferritin concentration and free thyroxine(fT4) level on the risk of GDM. Method: Women who receiving antenatal care were included this study from December 2012 to March 2014 in a tertiary gynecology and obstetrics hospital in Shanghai, China. A blood sample was obtained for measurement of serum ferritin and free thyroxine(fT4) in early pregnancy. Women were divided into six groups according to serum ferritin concentration and fT4 level. Multivariate logistical regression model was used to estimate adjusted odds ratios(OR) and 95% confidence interval(95%CI) among different groups. Results: A total of 6,542 qualifying pregnant women was included in this study. We observed that high serum ferritin concentration in early pregnancy is associated with an increasing risk of GDM, but not low free thyroxine level. When combined them together, we observed an increasing risk of GDM only among women with higher serum ferritin and normal fT4 level compared women with normal serum ferritin concentration and fT4 level(adjusted OR=1.25, 95% CI: 1.05～1.49), but not among women with high serum ferritin concentration and low free thyroxine level. Conclusion: We concluded that low fT4 might have a modification effect on the association between serum ferritin and risk of GDM.

关键词： serum ferritin free thyroxine gestational diabetes mellitus isolated hypothyroxinemia

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Journal of Nutritional Oncology 2020年第4期5卷 189-195页

作者： Fei Fei Guo Shi Jia Cheng Yi Ning Liu Jiu Wei Cui Cancer Center The First Hospital of Jilin UniversityChangchunJilin 130021China

Background An increasing number of studies have shown that iron,one of the indispensable trace elements in the human body,is closely related to the occurrence and development of ***,few studies have clearly demonstrated the role of the iron levels in lung cancer patients,or the potential effects of inflammation on iron *** The clinical data for lung cancer patients and non-lung cancer participants were retrospectively *** serum iron and ferritin levels were measured and compared using a rank-sum *** correlation between the serum iron/ferritin and C-reactive protein(CRP)was analyzed by rank *** cut-off values for continuous variables were obtained by the receiver operating characteristic curve(ROC)*** analysis of potential prognostic factors in lung cancer patients was conducted by univariate and multivariate survival *** The serum iron levels in patients with extensive small-cell lung cancer(SCLC)were lower than those with limited-stage SCLC,and the levels of serum ferritin and CRP in those with extensive SCLC were higher than those with limited-stage ***,the serum iron levels in patients with stage IV non-small cell lung cancer(NSCLC)were lower than those of patients with stageⅠ-Ⅲdisease,and the levels of serum ferritin and CRP in those with stage IV NSCLC were higher than those in stagesⅠ-Ⅲ.The serum iron level was negatively correlated with the level of CRP,while the serum ferritin level was positively correlated with *** stage of lung cancer,but not the serum iron/ferritin level,was an independent prognostic factor in lung cancer *** The serum iron and ferritin levels are associated with the staging of lung *** later stages of lung cancer are associated with a lower serum iron level,a higher serum ferritin level,and a higher CRP *** may play an important role in regulating the serum iron and ferritin levels in lung cancer patients.

关键词： serum iron serum ferritin Lung cancer Inflammation Iron metabolism

Role of doxycycline in the treatment of dengue infection: An open-label, randomized, controlled, pilot trial

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Asian Pacific Journal of Tropical Medicine 2024年第4期17卷 160-165页

作者： Banothu Vinod Kumar Kajal Kamboj Ashok Kumar Pannu Ashok Kumar Yadav Mandip Bhatia Atul Saroch Department of Internal Medicine PGIMER ChandigarhIndia Department of Experimental Medicine&Biotechnology PGIMER ChandigarhIndia

Objective:To measure the effect of doxycycline on inflammatory marker[IL-6,TNF-α,ferritin and C reactive protein(CRP)]levels in patients with dengue ***:A single-centre,open-label,parallel-group randomized controlled trial was done in PGIMER Chandigarh from June 2021 to October *** were randomized using a simple randomization process into two groups:the doxycycline treatment group(n=35)and the control group(n=34).Patients in the treatment group were given oral doxycycline 100 mg twice daily for five days along with standard treatment,whereas patients in the control group received only standard *** objective was to measure the effect of doxycycline on inflammatory markers in dengue ***:On comparative analysis at day 5,there was a statistically significant reduction in the median values of ferritin and CRP in cases compared to the control group(ferritin:P=0.006 and CRP:P=0.006).No significant reduction was noted in the levels of IL-6 and TNF-α.Conclusions:Doxycycline treatment led to a reduction of inflammatory markers in dengue infection.

关键词： Dengue Cytokine Doxycycline serum ferritin C reactive protein

Systemic autoimmune abnormalities complicated by cytomegalovirus-induced hemophagocytic lymphohistiocytosis:A case report

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World Journal of Clinical Cases 2020年第20期8卷 4946-4952页

作者： Shu-Xian Miao Zhi-Qi Wu Hua-Guo Xu Department of Laboratory Medicine The First Affiliated Hospital of Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina

BACKGROUND Hemophagocytic lymphohistiocytosis(HLH)is a rare but life-threatening disorder,characterized by a hyperimmune *** mortality is high despite progress being made in the diagnosis and treatment of the *** is traditionally divided into primary(familial or genetic)and secondary(reactive)according to the *** HLH(sHLH),more common in adults,is often associated with underlying conditions including severe infections,malignancies,autoimmune diseases,or other *** SUMMARY The case involves a 31-year-old woman,presented with a high persistent fever,rash,and *** met the diagnostic criteria of the HLH-2004 guideline and thus was diagnosed with HLH,with positive anti-nuclear antibody(ANA)and positive cytomegalovirus(CMV)-*** patient responded well to a combination of immunomodulatory,chemotherapy,and supportive *** her PCR evaluation for CMV turned negative,her serum ferritin also dropped *** clinical symptoms improved dramatically,and except for ANA,the abnormal laboratory findings associated with HLH returned to *** previous study has shown that the median overall survival of HLH patients is only 6 mo;however,our patient has been cured and has not presented with any relapse of the disease for 6 *** This case emphasizes that thorough early removal of the CMV infection is significant for the prognosis of this HLH patient.

关键词： Hemophagocytic lymphohistiocytosis Autoimmune abnormalities Cytomegalovirus Anti-nuclear antibody serum ferritin Case report