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differentially Expressed serum protein Profiling in Esophageal Squamous Cell Carcinoma Patients with Different Chinese Medicine Syndromes

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Chinese Medicine and Natural Products 2021年第1期1卷 1-12页

作者： SI Fuchun SONG Xuejie SI Gao Academy of Chinese Medicine Science Henan University of Chinese MedicineZhengzhouHenan 450046China Department of Orthopaedic the Thind Hospital of Peking UniversityBeijing 100083.China

Objective:Esophageal carcinoma is the eighth most common malignant tumor and ranked the sixth cause of death in the worldwide *** find out effective serum markers for early diagnosis and targeted treatment is important to improve esophageal carcinoma survival *** aim of this study was to screen differ-entially expressed serum protein profiling in esophageal squamous cell careinoma(ESCC)patients with differ-ent Chinese medicine syndrome and establish ESCC syndrome diagnosis model,to explore the signifcance of ESCC serum differential protein in traditional Chinese medicine(TCM)syndrome diagnosis and provide exper-imental and theoretical basis for the diagnosis,clinical treatment of ***:serum specimens of 80 ES-CC patients with different syndrome and 20 healthy people were selected according to distribution of their sex and *** beads based weak cation exchange combined w ith matrix-assist ed laser desorption/ionization time-of-flight mass spectrometry prot eomic technology and Autoflex Analysis and ClinProTools software were applied to screen differentially expressed serum protein *** establishing each syndrome group diag-nosis model and verifying with new samples to evaluate the diagnosis value of each syndrome group diagnosis ***:18 significantly differential expression protein peaks were screened between the whole ESCC patients sera and the healthy control *** with normal control group,among which,ten were signif-cant down-regulation with m/z values of4210,4267,4054,4248,2106,4091,2991,5337,3952,822,and eight were significant up-regulation with m/z values of 2900,2883,1467,1617,2862,2600,895,*** were 16,12,11,15 differentially expressed protein peaks in phlegm and qi stagnat ion syndrome(Group P),fluid insufficiency and heat agglomeration syndrome(Group F),blood stasis syndrome(Group B),qi and yang deficiency syndrome(Group Q),*** with m/z of4210,4091,4054 and 5337 presen-ted obvi

关键词： esophageal squamous cell carcinoma(ESCC) esophageal carcinoma serum differential protein traditional Chi-nese medicine different syndrome MALDI-TOF-MS

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