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Antioxidant phenolic compounds from seeds of Hordeum vulgare *** diabetic nephropathy in streptozotocin-induced diabetic rats

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Journal of Traditional Chinese Medical Sciences 2023年第3期10卷 353-361页

作者： Renuka Mahajan Satyendra Prasad Sanjana Gaikwad Prakash Itankar Nagpur College of Pharmacy Dr.Babasaheb Ambedkar Technological UniversityNagpur 441110India Department of Pharmaceutical Sciences Rashtrasant Tukadoji Maharaj Nagpur UniversityNagpur 440033India

Objective:To examine the effects of hydroalcoholic extract and fractions of Hordeum vulgare Linn.(***,Da Mai)on streptozotocin(STZ)-induced diabetic nephropathy in Sprague-Dawley rat ***:The study involved preliminary phytochemical screening of extract and fractions,estimation of secondary metabolites,chromatographic studies using high performance liquid chromatography(HPLC),antioxidant potential using 1,1-diphenyl-2-picrylhydrazyl(DPPH),nitric oxide radical scavenging and reducing power methods along with the determination of potential against diabetic nephropathy in STZ-induced rat ***:The phytochemical evaluation of the hydroalcoholic extract of *** and fractions revealed the presence of various phytoconstituents such as alkaloids,saponins,tannins,flavonoids,and *** chromatographic analysis indicated the peak complementing marker compound epicatechin and significant antioxidant activity in the extract and aqueous ***-induced rats showed abnormal levels of serum albumin,creatinine,total cholesterol,blood urea nitrogen(BUN),and triglycerides,and urine albumin and creatinine,which returned to normal after 8 weeks of treatment with hydroalcoholic extract(400 mg/kg)and aqueous fraction(50 mg/kg)of ***:Hydroalcoholic extract(400 mg/kg)and aqueous fraction(50 mg/kg)of *** have significant antioxidant potential and positive effects on diabetic *** fractionation and optimization increase the concentration of polyphenols in aqueous extract,causing a decrease in the dose required for effects against diabetic nephropathy.

关键词： Fractionation HPLC DPPH Nitric oxide radical scavenging serum albumin Creatinine Blood urea nitrogen

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Implications of preoperative hypoalbuminemia in colorectal surgery

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World Journal of Gastrointestinal Surgery 2016年第5期8卷 353-362页

作者： Adam Truong Mark H Hanna Zhobin Moghadamyeghaneh Michael J Stamos Division of Colon and Rectal Surgery Depart-ment of SurgeryUniversity of CaliforniaIrvine Medical Center

serum albumin has traditionally been used as a quantitative measure of a patient's nutritional status because of its availability and low cost. While malnutrition has a clear definition within both the American and European Societies for Parenteral and Enteral Nutrition clinical guidelines, individual surgeons often determine nutritional status anecdotally. Preoperative albumin level has been shown to be the best predictor of mortality after colorectal cancer surgery. Specifically in colorectal surgical patients, hypoalbuminemia significantly increases the length of hospital stay, rates of surgical site infections, enterocutaneous fistula risk, and deep vein thrombosis formation. The delay of surgical procedures to allow for preoperative correction of albumin levels in hypoalbuminemic patients has been shown to improve the morbidity and mortality in patients with severe nutritional risk. The importance of preoperative albumin levels and the patient's chronic inflammatory state on the postoperative morbidity and mortality has led to the development of a variety of surgical scoring systems to predict outcomes efficiently. This review attempts to provide a systematic overview of albumin and its role and implications in colorectal surgery.

关键词： Colorectal surgery Malnutrition albumin Hypoalbuminemia Prealbumin serum albumin Nutrition

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serum Protein Level Is Related to ADL in Patients with Parkinson’s Disease

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Open Journal of Nursing 2022年第11期12卷 738-744页

作者： Lihe Huang Xuezhen Deng Jieyi Yang Xuemei He Yanchun Zhu Lijian Chen Neurology Department Affiliated Brain Hospital of Guangzhou Medical University Guangzhou China Guangzhou Medical University Guangzhou China

Objectives: To establish an ADL prediction model for Parkinson’s inpatients as an auxiliary evaluation scheme. Methods: The data of Parkinson’s patients hospitalized in the Department of Neurology of Affiliated Brain Hospital of Guangzhou Medical University from 2019 to 2022, which suited the criteria were collected, and a multiple linear regression model was established with serum total protein, serum albumin, age, BMI and education level as independent variables and BI scores as dependent variables. Results: A total of 95 PD patients were included (mean 70.05 ± 10.87 years): 53 males and 42 females. The correlation analysis showed that the serum total protein (r = 0.398, P Conclusion: The ADL multiple linear regression model can be used as an important means to evaluate the ADL ability of PD patients in hospital.

关键词： Parkinson’s Disease Nursing serum Total Protein serum albumin Activities of Daily Living

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Scavenger receptor A-mediated nanoparticles target M1 macrophages for acute liver injury

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Asian Journal of Pharmaceutical Sciences 2023年第3期18卷 118-131页

作者： Rongping Zhang Shiqing Luo Ting Zhao Mengying Wu Lu Huang Ling Zhang Yuan Huang Huile Gao Xun Sun Tao Gong Zhirong Zhang Key Laboratory of Drug Targeting and Drug Delivery Systems Ministry of EducationSichuan UniversityChengdu 610041China College of Polymer Science and Engineering Sichuan UniversityChengdu 610041China

Acute liver injury(ALI)has an elevated fatality rate due to untimely and ineffective ***,schisandrin B(SchB)has been extensively used to treat diverse liver diseases,its therapeutic efficacy on ALI was limited due to its high *** acid-modified serum albumin(PSA)is not only an effective carrier for hydrophobic drugs,but also has a superb targeting effect via scavenger receptor-A(SR-A)on the M1 macrophages,which are potential therapeutic targets for *** with the common macrophage-targeted delivery systems,PSA enables site-specific drug delivery to reduce off-target ***,we prepared SchB-PSA nanoparticles and further assessed their therapeutic effect on *** vitro,compared with human serum albumin encapsulated SchB nanoparticles(SchB-HSA NPs),the SchB-PSA NPs exhibited more potent cytotoxicity on lipopolysaccharide(LPS)stimulated Raw264.7(LAR)cells,and LAR cells took up PSA NPs 8.79 times more than HSA *** expected,the PSA NPs also accumulated more in the ***,SchB-PSA NPs dramatically reduced the activation of NF-κB signaling,and significantly relieved inflammatory response and hepatic ***,the high dose of SchB-PSA NPs improved the survival rate in 72 h of ALI mice to 75%.Hence,SchB-PSA NPs are promising to treat ALI.

关键词： Acute liver injury M1 macrophages Schisandrin B Palmitic acid-modified human serum albumin

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心灵丸

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实用医学杂志 1995年第5期 351-351页

心灵丸广东省潮州市宏兴制药厂生产的心灵丸，是广东省科委、经委重点科研项目的优秀成果；是根据祖国医学活血化瘀、益气强心的原则，选用熊胆、麝香、牛黄。珍珠、人参。田七等经提炼研制而成的治疗冠心病的特效、速效纯中药制剂。心... 详细信息

心灵丸广东省潮州市宏兴制药厂生产的心灵丸，是广东省科委、经委重点科研项目的优秀成果；是根据祖国医学活血化瘀、益气强心的原则，选用熊胆、麝香、牛黄。珍珠、人参。田七等经提炼研制而成的治疗冠心病的特效、速效纯中药制剂。心灵丸具有活血化瘀、益气强心、定心安...

关键词： serum albumin microspheres, oxymatrine matrine sustained release

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