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Dynamical Changes of the serum Nitric Oxide(NO) Concentrations after Subarachnoid Hemorrhage(SAlH) and the Effects of Acanthopanax Senticosus

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中国临床神经科学 2000年第Z1期8卷 74-页

作者： She Zheng Ming Qian Hong Fa Department of Neurology the People' s Hospital of Hongze County. Hong ze223100 Department of Medicine the People's Hospilal of Wuxian City Wuxian215128

Objective. To explore the dynamical changes of the serum no concentrations after SAH and the effects of acanthopanax senti cosus. Background. No, as a vascul ar regulat i on factor, Plays an important role on cerebral blood circulation .High intention has been paid to the rclationaship betveen No and cerebral vasospasm following SAH. Methods. The serum no concentrat,ons of simple SAH group and acanthopanax senticosus--treated group were dynamically measured in the 2nd, 4th and 6th day after onset. Results. The serum no concentrations of simple SAH group and acanthopanax scnticosus-treated group in the 4th and 6th day after onset were obviously lower than those of control group(P＜0.01,P＜0.05).The serum no concentrations of the two groups reached their minimum in the 4th day after onset and then went up gradually in the 6th day. The content of the red blood cell in the cerebrospinal tiui of the simple SAH group was significamily contrary related to the serum N0 concentration in the 4 th day (r=-0. 69. P＜ 0. 01). Discussion. The Sources , Synthesis, functious of No , the relationship between No and SAl and the effects of acanthopanax Senticoaus were discussed. Conclusion. The serum no concentrations of the patients after SAH decrease and that may be involvea in the mechanism of cerebral vasospasm (CVS). Acanthopanax senticosus can increase the serum no concentrations.

关键词： Nitric Oxide cerebral vasospasm serum no blood circulation

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