检索结果-南通市图书馆

A defect in the PINOID serine/threonine kinase affects leaf shape in cucumber

Journal of Integrative Plant Biology 2019年第9期61卷 966-967页

作者： Jennifer Mach Peridot Scientific Communications

Examining the plants in any forest or meadow reveals a remarkable diversity of leaf shape,suggesting the importance of this trait for adaptation to various environmental conditions(reviewed in Nicotra et al.2011).Indeed,leaf shape may be constrained by biomechanical factors and affects thermoregulation,susceptibility to herbivory,the available light for photosynthesis,and water balance.

关键词： the PINOID serine/threonine kinase leaf shape in cucumber Examining

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Novel serine/threonine kinase 11 gene mutations in PeutzJeghers syndrome patients and endoscopic management

引用

World Journal of Gastrointestinal Endoscopy 2013年第3期5卷 102-110页

作者： Hiroyuki Yajima Hajime Isomoto Hiroaki Nishioka Naoyuki Yamaguchi Ken Ohnita Tatsuki Ichikawa Fuminao Takeshima Saburo Shikuwa Masahiro Ito Kazuhiko Nakao Kazuhiro Tsukamoto Shigeru Kohno Department of Molecular Microbiology and Immunology Nagasaki University Graduate School of Biomedical SciencesNagasaki University School of MedicineNagasaki 852-8501Japan Department of Gastroenterology and Hepatology Nagasaki University School of MedicineNagasaki 852-8501Japan Department of Pharmacotherapeutics Nagasaki University Graduate School of Biomedical SciencesNagasaki University School of MedicineNagasaki 852-8521Japan Department of Pathology National Nagasaki Medical CenterOmuraNagasaki 856-0835Japan

AIM:To explore mutations in serine/threonine kinase 11(STK11) gene in Peutz-Jeghers syndrome(PJS) with gastrointestinal(GI) hamartomatous ***:Six Japanese PJS patients in 3 families were enrolled in this *** of the cases had hamartomatous polyposis in the gastrointestinal tract,including the small intestine,along with mucocutaneous ***-band imaging(NBI)-magnification endoscopy was employed to detect microvascular and microsurface irregularities in the GI *** magnification findings could be classified into three groups(type A,type B,or type C).Endoscopic polypectomy was performed using double-balloon enteroscopy or *** DNA was extracted from a whole blood sample from each *** of the coding exons of STK11 gene,its boundary regions,and the promoter region containing the polymorphic regions were amplified by polymerase chain reaction,and direct sequencing was performed to assess the germline ***:NBI-magnification endoscopic observation could detect the abnormalities in microvessels and microsurface structures of GI ***,we found 5 cases of type A and one case without the examination for the gastric polyps,while there were 4 cases of type B and 2 case of type A for the colorectal ***-nine small-bowel and 115 colorectal polyps over 27 sessions for each were resected endoscopically without significant *** only delayed complication included the occurrence of bleeding in a case,and this was successfully managed with *** polyps contained no malignant *** on mutation analysis,all 3 cases in Family I exhibited the +658C>T nonsense mutation in exon 5,which resulted in the production of a truncated protein(Q220X).In Family II,a case had-252C>A and-193C>A in the promoter *** Family III,a case was found to have the +1062C>G(F342L) mutation in exon ***:We found two novel mutations of STK11 in association with ***

关键词： Peutz-Jeghers syndrome serine/threonine kinase 11 Gastrointestinal hamartomatous polyps Double-balloon enteroscopy Narrow-band imaging

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Molecular cloning and expression analysis of a novel human cDNA fragment encoding a putative Ser/Thr protein kinase

引用

Chinese Science Bulletin 1999年第9期44卷 778-783页

作者： Qi Zhang Fangyan Dai Min Zhang Peirong Hu Qiang Fu Yuxin Fan Long Yu Shouyuan Zhao Fudan Univ Inst Genet State Key Lab Genet Engn Shanghai 200433 Peoples R China

A novel full-length cDNA encoding a putative serine/threonine kinase has been isolated from a human testis cDNA library. A nucleotide sequence of 1 225 bp length has been determined containing an open reading frame of 1 044 nucleotides (encoding 348 amino acids). In view of its degree of homology to members of the Ser/Thr protein kinase family and the closest relationship to Mus musculus STK-1, the predicted product was designated by the name of HUMSTK-1. Its mRNA is present in large amounts in thymus, and small amounts in testis,small intestine and colon.

关键词： serine/threonine kinase cDNA cell cycle homology.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis

引用

World Journal of Gastrointestinal Pharmacology and Therapeutics 2010年第3期1卷 75-80页

作者： Javier Escobar Javier Pereda Alessandro Arduini Juan Sastre Juan Sandoval Luis Aparisi Gerardo López-Rodas Luis Sabater Department of Physiology University of Valencia 46100 Burjasot (Valencia) Spain Department of Biochemistry & Molecular Biology University of Valencia 46100 Burjasot (Valencia) Spain Laboratory of Pancreatic Function University Clinic Hospital 46010 Valencia Spain Department of Surgery University Clinic Hospital 46010 Valencia Spain

Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death due to multiple organ failure. Acinar cells, together with leukocytes, trigger the inflammatory cascade in response to local damage of the pancreas. Amplification of the inflammatory cascade requires up-regulation of proinflammatory cytokines and this process is mediated not only by nuclear factor κB but also by chromatinmodifying complexes and chromatin remodeling. Among the different families of histone acetyltransferases, the p300/CBP family seems to be particularly associated with the inflammatory process. cAMP activates gene expression via the cAMP-responsive element (CRE) and the transcription factor CRE-binding protein (CREB). CREB can be phosphorylated and activated by different kinases, such as protein kinase A and MAPK, and then it recruits the histone acetyltransferase co-activator CREB-binding protein (CBP) and its homologue p300. The recruitment of CBP/p300 and changes in the level of histone acetylation are required for transcription activation. Transcriptional repression is also a dynamic and essential mechanism of down-regulation of genes for resolution of inflammation, which seems to be mediated mainly by protein phosphatases (PP1, PP2A and MKP1) and histone deacetylases(HDACs) .Class HDACs are key transcriptional regulators whose activities are controlled via phosphorylationdependent nucleo/cytoplasmic shuttling. PP2A is responsible for dephosphorylation of class HDACs, triggeringnuclear localization and repression of target genes, whereas phosphorylation triggers cytoplasmic localization leading to activation of target genes. The potential benefit from treatment with phosphodiesterase inhibitors and histone deacetylase inhibitors is discussed.

关键词： Dual specificity protein phosphatases Acute pancreatitis Phosphodiesterase inhibitors Cytokines Histone acetylation Pentoxifylline PP2A serine/threonine protein phosphatases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：