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Liquid-liquid phase separation in DNA double-strand break repair

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Cancer Biology & Medicine 2023年第9期20卷 627-632页

作者： Jia Chen Jie Shi Jian Zheng Yunlong Wang Xiangbo Wan Henan Provincial Key Laboratory of Radiation Medicine The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Academy of Medical Sciences Zhengzhou UniversityZhengzhou 450052China Department of Radiation Oncology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Radiation Oncology The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China

DNA repair factors function through spatiotemporal condensation and dissolution at DNA double-strand breaks(DSBs).Recent advances have indicated that some DSB repair factors undergo liquid-liquid phase separation(LLPS)and show droplet-like properties,as well as dynamic material exchange.Importantly,LLPS regulates various biological processes,and aberrant LLPS is involved in the pathologic progression of various diseases.

关键词： separation double liquid

Screening and design of COF-based mixed-matrix membrane for CH_(4)/N_(2) separation

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Chinese Journal of Chemical Engineering 2022年第2期35卷 170-177页

作者： Tongan Yan Dahuan Liu Qingyuan Yang Chongli Zhong State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical TechnologyBeijing 100029China State Key Laboratory of separation Membranes and Membrane Processes Tiangong UniversityTianjin 300387China

Membrane separation is a high-efficiency,energy-saving,and environment-friendly separation technology.Covalent organic framework(COF)-based mixed-matrix membranes(MMMs)have broad application prospects in gas separation and are expected to provide new solutions for coal-bed methane purification.Herein,a high-throughput screening method is used to calculate and evaluate COF-based MMMs for CH_(4)/N_(2) separation.General design rules are proposed from thermodynamic and kinetic points of view using the computation-ready,experimental COFs.From our database containing 471,671 generated COFs,5 COF membrane materials were screened with excellent membrane selectivities,which were then used as the filler of MMMs for separation performance evaluation.Among them,BAR-NAP-Benzene_CF_(3) combined with polydimethylsiloxane and styrene-b-butadiene-b-styrene show high CH_(4) permeability of 4.43×10^(-13) mol·m·s^(-1)·Pa^(-1)·m^(-2) and high CH_(4)/N_(2) selectivity of 9.54,respectively.The obtained results may provide reasonable information for the design of COF-based membranes for the efficient separation of CH_(4)/N_(2).

关键词： Covalent organic frameworks Methane Molecular simulations Mixed-matrix membrane Nitrogen separation

Sulfonylcalix[4]arene-based metal-organic polyhedra with hierarchical porous structures for efficient Xe/Kr separation

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Nano Research 2023年第2期16卷 2536-2542页

作者： Wei-Long Shan Mao-Lian Xu Huan-Huan Hou Peng Zhao Qing-Yun Zhang Meng-Jia Yin Feng Luo School of Chemistry and Chemical Engineering Anhui University of TechnologyMaanshan 243002China State key Laboratory of Nuclear Resources and Environment School of ChemistryBiology and Material ScienceEast China University of TechnologyNanchang 330013China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China

Multiple space from the interior of metal-organic polyhedra(MOPs),the exterior among MOPs,and the inherent nature of big organic molecules makes MOPs as promising platform with hierarchical porous structures,especially when well-elucidated reticular chemistry principles were used.Herein we describe the preparation of a series of isoreticular octahedral MOPs featuring Zn4-p-tert-butylsulfonylcalix[4]arene clusters by the metal-directed assembly of three rigid organic ligands with different lengths.Intercage hydrogen-bonds and hydrophobic interactions between sulfonylcalix[4]arene groups direct the stacking of discrete MOPs into a novel permanent hierarchical porous material.More importantly,the optimal MOP 1-Zn exhibits high adsorption capacity of Xe and excellent Xe/Kr(20/80,v/v)separation performance,as demonstrated by adsorption isotherms,breakthrough experiments,and density functional theory calculations.Additionally,grand canonical Monte Carlo(GCMC)and dispersion-corrected density functional theory(DFT-D)theoretical calculations provide molecular-level insight over the adsorption/separation mechanism.

关键词： metal-organic polyhedral sulfonylcalixarene hierarchical porous material Xe/Kr separation

Tuning d-spacing of graphene oxide nanofiltration membrane for effective dye/salt separation

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Rare Metals 2023年第2期42卷 418-429页

作者： Chao Xing Chang-Yu Liu Chao Lai Shan-Qing Zhang Center for Clean Environment and Energy School of Environment and ScienceGold Coast CampusGriffith UniversitySouthportQLD4222Australia School of Chemistry and Materials Science Jiangsu Normal UniversityXuzhou221116China School of Biotechnology and Health Sciences Wuyi UniversityJiangmen529020China

The interlayer spacing(i.e.,d-spacing)plays a crucial role in determining the selectivity and permeability of nanofiltration membranes.A high-throughput directional filtration can be achieved by designing and controlling the d-spacing.In this study,the d-spacing of a graphene oxide(GO)membrane was tuned and fixed to the desired value(approximately 0.79 nm)using a solution of polyethyleneimine(PEI)and GO at a PEI/GO mass ratio of15:1.The resultant PEI/GO was deposited on a polyacrylonitrile(PAN)substrate to form a robust composite nanofiltration membrane(a PEI/GO@PAN membrane).The as-prepared membrane exhibited an ultrahigh flux of117.8 L·m^(-2)·h^(-1),and the rejection values for Direct Red80(DR80)and Na_(2)SO_(4)reached 99.7%andseparation.The PEI/GO@PAN membrane exhibited an excellent filtration performance,and had a longer lifespan and excellent reusability because of its reinforced nature.This work suggested that tuning the d-spacing with PEI would be an effective strategy to achieve the anticipated functions of nanofiltration membranes.

关键词： separation Nanofiltration Graphene oxide Membrane d-spacing

Flotation separation of spodumene and albite with activation of calcium ion hydrolysate components

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Rare Metals 2022年第11期41卷 3919-3931页

作者： Xian-Ping Luo Yong-Bing Zhang He-Peng Zhou Fan-Xin Xie Zhi-Zhao Yang Bo-Yuan Zhang Cai-Gui Luo Engineering Research Center for High-Efficiency Development and Application Technology of Tungsten Resources(Jiangxi University of Science and Technology) Ministry of EducationGanzhou341000China Jiangxi Province Key Laboratory of Mining and Metallurgy Environmental Pollution Control Jiangxi University of Science and TechnologyGanzhou341000China

It is difficult to separate spodumene and albite by flotation with calcium ion as activator.In this study,microflotation experiment,solution chemistry calculation,density functional theory(DFT)calculation and X-ray photoelectron spectroscopy(XPS)analysis were conducted to investigate the effect mechanism of c alcium hydrolysate on the flotation separation of spodumene and albite.Results show that the weak interaction intensity of Ca^(2+)with O atoms on the mineral surface makes it difficult to activate minerals effectively.The O atom in the hydroxyl group of Ca(OH)^(+)and Ca(OH)_(2)can be strongly bonded with Al atom on the mineral surface,which greatly improves the adsorption strength.After the activation of Ca(OH)^(+),the adsorption forms of collectors on the surface of spodumene and albite are quite different,and the adsorption intensity on the surface of spodumene is higher,which is conducive to the flotation separation of spodumene and albite.After the action of Ca(OH)_(2),the adsorption of the collector on the albite surface is stronger than that of spodumene,which is not conducive to the flotation separation of the two minerals.By adjusting the initial concentration of calcium ions and pulp pH,Ca(OH)^(+)is the main active component,which is the key to improve the separation effect of spodumene and albite.

关键词： Spodumene Albite Calcium ions Hydrolysate components Flotation separation

Fine-tuned mesoporous covalent organic frameworks for highly efficient low molecular-weight proteins separation

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Nano Research 2022年第5期15卷 4569-4574页

作者： Tienan Wang Irfan Azhar Yuting Yang Yao Lu Yuyang Tian Nan Gao Fengchao Cui Li Yang Xiaofei Jing Guangshan Zhu Department of Chemistry Northeast Normal UniversityChangchun 130024China

Covalent organic frameworks(COFs)are prominent porous materials for molecules separation due to their desirable structures.However,very few COFs are reported for the separation of macromolecules such as low molecular-weight(MW)proteins.Here,two stable mesoporous COFs(Azo-COF and Tp-COF)with highly crystallized frameworks are synthesized,and their pore sizes are slightly-regulated via elaborate selection of pyrene knots and amino linkages.Benefiting from the pore size difference less than 4 ?,the tandem utilization of these two COFs exhibits efficiently size-selective separation ability towards low MW proteins cytochrome c and myoglobin with small MW difference of 2 kDa,in which protein adsorption possibilities are verified by computational calculations together with confocal laser scanning microscopy(CLSM).Furthermore,a simple COF-based separation device is designed and prepared to achieve effective and low-consumption proteins separation.This work has offered an optimized synthetic strategy for fine-tuned mesoporous COFs and expanded their applications on macromolecules separation.

关键词： covalent organic frameworks mesoporous materials pore regulation separation low molecular-weight protein

Research progress of rare earth separation methods and technologies

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Journal of Rare Earths 2023年第2期41卷 182-189页

作者： Mory Traore Aijun Gong Yiwen Wang Lina Qiu Yuzhen Bai Weiyu Zhao Yang Liu Yi Chen Ying Liu Huilin Wu Shuli Li Yueyi You School of Chemistry and Biological Engineering University of Science and Technology BeijingBeijing 100083China b Beijing Key Laboratory for Science and Application of Functional Molecular and Crystalline Materials University of Science and Technology BeijingBeijing 100083China

Strategical elements,such as rare earth elements,play a crucial role in the industry,especially in producing high-tech materials.Major global industries have developed a strong dependence on rare earth materials.Every year,there are innovations in industries such as modern technology,green energy,or communications technology,which need more strategic metals to improve investment profitability.This article reviews advances in rare earth separation methods and techniques to guide and recommend the best extractants,depending on leaching conditions and the final target product.Each method for separating and extracting agents is individually revised in terms of the mechanism and interaction of providing rare earth elements.This paper also evaluates past and current trends of these methods and technical extractants and identifies their strengths and weaknesses.

关键词： Rare earth separation Extraction Extractant

Highly selective separation of propylene/propane mixture on cost-effectively four-carbon linkers based metal-organic frameworks

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Chinese Journal of Chemical Engineering 2022年第11期51卷 126-134页

作者： Daofei Lv Junhao Xu Pingjun Zhou Shi Tu Feng Xu Jian Yan Hongxia Xi Zewei Liu Wenbing Yuan Qiang Fu Xin Chen Qibin Xia School of Environmental and Chemical Engineering Foshan UniversityFoshan 528000China School of Chemistry and Chemical Engineering South China University of TechnologyGuangzhou 510641China Sichuan Jinyuansheng New Energy Technology Co. LtdMeishan 620010China

The separation of propylene and propane is an important but challenging process,primarily achieved through energy-intensive distillation technology in the petrochemical industry.Here,we reported two natural C4linkers based metal–organic frameworks(MIP-202 and MIP-203)for C_(3)H_(6)/C_(3)H_(8)separation.Adsorption isotherms and selectivity calculations were performed to study the adsorption performance for C_(3)H_(6)/C_(3)H_(8)separation.Results show that C_(3)H_(6)/C_(3)H_(8)uptake ratios(298 K,100 kPa)for MIP-202 and MIP-203 are 2.34 and 7.4,respectively.C_(3)H_(6)/C_(3)H_(8)uptake ratio(303 K,100 k Pa)for MIP-203 is up to50.0.The mechanism for enhanced separation performance of C_(3)H_(6)/C_(3)H_(8)on MIP-203 at higher temperature(303 K)was revealed by the in situ PXRD characterization.The adsorption selectivities of C_(3)H_(6)/C_(3)H_(8)on MIP-202 and MIP-203(298 K,100 k Pa)are 8.8 and 551.4,respectively.The mechanism for the preferential adsorption of C_(3)H_(6)over C_(3)H_(8)in MIP-202 and MIP-203 was revealed by the Monte Carlo simulation.The cost of organic ligands for MIP-202 and MIP-203 was lower than that of organic ligands for those top-performance MOFs.Our work sets a new benchmark for C_(3)H_(6)sorbents with high adsorption selectivities.

关键词： Propylene Propane separation Gas Adsorption Metal-organic frameworks

Nanostructure enabled extracellular vesicles separation and detection

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Nanotechnology and Precision Engineering 2023年第4期6卷 98-120页

作者： Xinyuan He Wei Wei Xuexin Duan State Key Laboratory of Precision Measuring Technology and Instruments Tianjin UniversityTianjin 300072China Department of Chemistry School of ScienceTianjin UniversityTianjin 300072China

Extracellular vesicles(EVs)have recently attracted significant research attention owing to their important biological functions,including cell-to-cell communication.EVs are a type of membrane vesicles that are secreted into the extracellular space by most types of cells.Several biological biomolecules found in EVs,such as proteins,microRNA,and DNA,are closely related to the pathogenesis of human malignancies,making EVs valuable biomarkers for disease diagnosis,treatment,and prognosis.Therefore,EV separation and detection are prerequisites for providing important information for clinical research.Conventional separation methods suffer from low levels of purity,as well as the need for cumbersome and prolonged operations.Moreover,detection methods require trained operators and present challenges such as high operational expenses and low sensitivity and specificity.In the past decade,platforms for EV separation and detection based on nanostructures have emerged.This article reviews recent advances in nanostructure-based EV separation and detection techniques.First,nanostructures based on membranes,nanowires,nanoscale deterministic lateral displacement,and surface modification are presented.Second,high-throughput separation of EVs based on nanostructures combined with acoustic and electric fields is described.Third,techniques combining nanostructures with immunofluorescence,surface plasmon resonance,surface-enhanced Raman scattering,electrochemical detection,or piezoelectric sensors for high-precision EV analysis are summarized.Finally,the potential of nanostructures to detect individual EVs is explored,with the aim of providing insights into the further development of nanostructure-based EV separation and detection techniques.

关键词： Nanostructure Extracellular vesicle separation Detection Individual