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Rapidly separable bubble microneedle patch for effective local anesthesia

Nano Research 2022年第9期15卷 8336-8344页

作者： Yuan Yang Huaqing Chu Yan Zhang Lingling Xu Ruizeng Luo Hui Zheng Tailang Yin Zhou Li CAS Center for Excellence in Nanoscience Beijing Key Laboratory of Micro-nano Energy and Sensor Beijing Institute of Nanoenergy and NanosystemsChinese Academy of SciencesBeijing 101400China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China Department of Anesthesiology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of Clinical Laboratory Renmin Hospital of Wuhan UniversityWuhan 430060China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety and CAS Center for Excellence in Nanoscience National Center for Nanoscience and TechnologyBeijing 100190China Reproductive Medicine Center Renmin Hospital of Wuhan UniversityWuhan 430060China School of Chemistry and Chemical Engineering Center on Nanoenergy ResearchGuangxi UniversityNanning 530004China Institute for Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China

In cutaneous cosmetology surgery,local injection or coated anesthetics are generally used to provide analgesia at the treatment site to achieve painless *** to the barrier of corneum,topical cream may cause uncertain dosage and delayed *** injection has problems such as pain,infection,and ***,it is necessary to develop a painless and rapid administration method for local ***,a lidocaine/hyaluronic acid bubble microneedle patch(Lido/HA bMNP)was prepared for rapid drug delivery and efficient *** bubble structure between microneedles(MNs)and the backing layer allowed the MNs to efficiently penetrate into the skin and remove from the backing layer under shear force to rapidly complete the *** were quickly released with the dissolution of HA within 15 s,which immediately played an analgesic effect and lasted for 1 ***/HA bMNP could deliver precise doses to the skin in an extremely short time,which had the advantages of convenient operation,high biosafety,rapid onset of analgesia,and reasonable pain relief *** patch provided an alternative way for local anesthesia and it was a promising transdermal drug delivery method for the realization of high quality and efficiency“painless medical beauty”.

关键词： separable bubble microneedle patch hyaluronic acid rapid drug delivery local anesthesia cutaneous cosmetology surgery

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