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Application of Forearm FMG signals in Closed Loop Modality-matched sensory Feedback stimulation

Journal of Bionic Engineering 2020年第5期17卷 899-908页

作者： Jing Wei Tan Yimesker Yihun Department of Mechanical Engineering Wichita State UniversityWichitaKansas 67260USA

This study is aimed at exploring a technology that can use the human physiological information,such as Force Myography(FMG)signals to provide sensory feedback to prosthetic hand users.This is based on the principle that with the intent to move the prosthetic hand,the existing limbs in the arm recruit specific group of muscles.These muscles react with a change in the cross-sectional area;piezoelectric sensors placed on these muscles will generate a voltage(FMG signals),in response to the change in muscle volume.The correlation between the amplitude of the FMG signals and intensity of pressure on fingertips during grasping is then computed and a dynamic relation(model)is established through system identification in MATLAB.The estimated models generated a fitting accuracy of more than 80%.The model is then programmed into the Arduino microcontroller,so that a real-time and proportional force feedback is channeled to amputees through a micro actuator.Obtaining such percentages of accuracy in sensory feedback without relying on touch sensors on the prosthetic hand that could be affected by mechanical wear and other interaction factors is promising.Applying advanced signal processing and classification techniques may also refine the findings to better capture and correlate the force variations with the sensory feedback.

关键词： FMG sensory feedback prosthetic hand bionic robot modality-matched sensory stimulation

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Ethanol modulates sensory information processing in cerebellar cortex

Ethanol modulates sensory information processing in cerebell...

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中国神经科学学会第十二届全国学术会议

作者： Mao-Cheng Wu Guang-Jian Zhang De-Lai Qiu Key Laboratory of Cellular Function and Pharmacology of Jilin Province Yanbian University

Overdose intake of ethanol can impair cerebellar cortical neurons to integrate and transfer external information, resulting in a dysfunction of cerebellar motor regulation or cerebellar ataxia. We recently investigated the effects of ethanol on sensory stimulation-evoked responses in the cerebellar cortex of urethane-anesthetized mice, by electrophysiological and pharmacological methods. We found that ethanol dosedependently inhibited the facial stimulation evoked field potential responses in cerebellar granule cell layer, whereas ethanol bidirectional modulate the sensory stimulation-evoked responses in molecular layer via GABAA receptor. In vivo patch-clamp recordings showed that ethanol dose-dependently inhibited the facial stimulation-evoked outward currents of cerebellar Purkinje cells（PCs）. The ethanol-induced inhibition of facial stimulation-evoked outward currents were significantly abrogated by cannabinoid receptor 1（CB1） antagonists and agonist. The ethanol-induced inhibition of facial stimulation-evoked outward currents was prevented by cerebellar surface perfusion of the PKA inhibitors H-89, but not by intracellular administration of the PKA inhibitor PKI. Our present results indicate that ethanol inhibits the facial stimulation-evoked outward currents by activating presynaptic CB1 receptors via the PKA signaling pathway, suggesting that ethanol overdose impairs sensory information processing, at least in part, by inhibiting GABA release from molecular layer interneurons onto PCs. In addition, ethanol inhibited the spontaneous CS-evoked pause in simple spike firing and in the amplitude of the afterhyperpolarization via activation of CB1 receptors in vivo in mice, suggesting that excessive ethanol intake inhibits climbing fiber–PC synaptic transmission by modulating CB1 receptors in the cerebellar cortex.

关键词： Ethanol Cerebellar Purkinje cell sensory stimulation in vivo whole-cell patch-clamp recording complex spike cannabinoids receptor 1 protein kinase A

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Effects of morphine dependence and withdrawal on sensory information processing in cerebellar granule cell layer in vivo in mice

Effects of morphine dependence and withdrawal on sensory inf...

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中国神经科学学会第十二届全国学术会议

作者： Li-jie Zhan Bing-xue Li Dan Wang De-lai Qiu Yan Lan Cellular Function Research Center Yanbian University Department of Physiology and Pathophysiology College of Medicine Yanbian University Department of pharmacology College of Medicine Yanbian University Key Laboratory of Natural Resource of the Changbai Mountain and Functional Molecular of the Ministry of Education Yanbian University

Background: It has been reported that the mechanisms of morphine addiction is the homeostasis dysregulation of brain. The cerebellum is involved in control of motor coordination and receives sensory inputs to execute complex motor tasks. Increasing evidence has involved that addiction is related to a disruption in cerebellar processing and connectivity with other brain regions. However, the changes of information processing in cerebellum in morphine addiction is unknown. In present research, our aim is to observe the effects of morphine dependence and withdrawal on sensory information processing in cerebellar granule cell layer in vivo in mice. Methods and Main Results: Forty male KM mice were randomly divided into four groups（n=10）: the morphine dependence group, morphine withdraw 1 day group, morphine withdrawal 7 days group, and the saline control group. The mice in dependence group and withdrawal group were administered with morphine by subcutaneous injection through the method of "increasing addiction for 7 days", and the saline group were injected saline. Mice administered morphine exhibited opioid-like responses including Straub tail and hyperlocomotion in behavior. Electrophysiological methods were used in our research to record the field potential of granule cell layer（GCL）. Air-puff stimulation of the ipsilateral whisker-pad evoked stimulus-on（N1） and stimulus-off responses（N2） in GCL of cerebellar Crus II. The amplitude of N1 and N2 in dependence group, withdrawal 1 day group and withdrawal 7 day group are obviously decreased compared with control group（p＜0.05）, and withdrawal 1 day group shows a marked drop compared with dependence group and withdrawal 7 day group（p＜0.05）. The onset latency of the sensory stimulationevoked responses has no change. Conclusion: These results indicate that morphine dependence and withdrawal affect the homeostatic regulation of sensory information processing in cerebellar granule cell layer.

关键词： Morphine dependence Morphine withdrawal Cerebellar granule cell Mice sensory stimulation

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