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Enriched environment elevates expression of growth associated protein-43 in the substantia nigra of SAMP8 mice

Neural Regeneration Research 2018年第11期13卷 1988-1994页

作者： Zhen-Yun Yuan Jie Yang Xiao-Wei Ma Yan-Yong Wang Ming-Wei Wang The First Hospital of Hebei Medical University Brain Aging and Cognitive Neuroscience Laboratory of Hebei Province Shijiazhuang Hebei ProvinceChina

An enriched environment protects dopaminergic neurons from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine（MPTP）-induced neuronal injury, but the underlying mechanism for this is not clear. Growth associated protein-43（GAP-43） is closely associated with neurite outgrowth and axon regeneration during neural development. We speculate that an enriched environment can reduce damage to dopaminergic neurons by affecting the expression of GAP-43. This study is designed to test this hypothesis. Three-month-old female senescence-accelerated mouse prone 8（SAMP8） mice were housed for 3 months in an enriched environment or a standard environment. These mice were then subcutaneously injected in the abdomen with 14 mg/kg MPTP four times at 2-hour intervals. Morris water maze testing demonstrated that learning and memory abilities were better in the enriched environment group than in the standard environment group. Reverse-transcription polymerase chain reaction, immunohistochemistry and western blot assays showed that m RNA and protein levels of GAP-43 in the substantia nigra were higher after MPTP application in the enriched environment group compared with the standard environment group. These findings indicate that an enriched environment can increase GAP-43 expression in SAMP8 mice. The upregulation of GAP-43 may be a mechanism by which an enriched environment protects against MPTP-induced neuronal damage.

关键词： nerve regeneration Parkinson's disease neural plasticity senescence-accelerated mouse prone 8 growth associated protein-43 substantia nigra learning and memory neural regeneration

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