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Decline in semen concentration of healthy Chinese adults： evidence from 9357 participants from 2010 to 2015

Asian Journal of Andrology 2018年第4期20卷 379-384页

作者： Hong-Fang Yuan Huang-Fang Shangguan Yi Zheng Tian-Qing Meng Cheng-Liang Xiong Huang-Tao Guan Family Planning Research Institute Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China College of Informatics Huazhong Agricultural University Wuhan 430070 China Department of Venereology Wuhan Institute of Dermatology and Venereology Wuhan 430031 China Reproductive Medicine Center Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China Hubei Province Human Sperm Bank Wuhan 430030 China

The present study aims to analyze sperm concentration trends among young and healthy Chinese adults in Wuhan, Central China, from 2010 to 2015. semen analysis data from 9357 participants were collected and analyzed using a general linear model and the Cochran-Armitage trend test. A significant decline was observed in sperm concentration （β [standard deviation]： -1.53 [0.16]; P 〈 0.001）. In addition, a decline in sperm density was observed by stratifying student versus nonstudent sperm donors and by analyzing the year of birth or birth year cohort of the participants. Furthermore, the percentage of participants with sperm densities of over 40×10^6 ml^-1 significantly decreased with year. Notably, a dramatic decline in sperm density was recorded over the first 5 years of study.

关键词： healthy men semen concentration sperm donors temporal trends

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concentrations of phthalates metabolites in blood and semen and the potential effects on semen concentration and motility among residents of the Pearl River Delta region in China

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Emerging Contaminants 2020年第1期6卷 39-43页

作者： Xiaofei Song Qiongfang Zhuo Shaoyu Tang Tianfa Xie Zhiyuan Chen Zhijun Zang Yanan Zhang Xiaojun Niu Hua Yin Feng Zeng Chang He School of Environment and Energy South China University of TechnologyGuangzhou510006China Research Center for Eco-Environmental Engineering Dongguan University of TechnologyDongguan523808GuangdongChina Guangdong Provincial Key Laboratory of Petrochemical Pollution Process and Control Guangdong University of Petrochemical TechnologyGuangdongChina School of Chemistry and Chemical Engineering Sun Yat-sen UniversityGuangzhou510275China Third Affiliated Hospital of Sun Yat-sen University Guangzhou510630China Queensland Alliance for Environmental Health Science(QAEHS) The University of QueenslandBrisbaneAustralia Department of Mechanical and Industrial Engineering University of Massachusetts AmherstAmherstMAUSA

Exposure to phthalate acid esters(PAEs)has been found to have adverse effects on reproduction of human and ***,the effects on the semen quality are *** this study,we have collected paired blood and sperm samples from patients(n=103)at a medical clinic in Guangzhou,China,to determine the concentrations of eight phthalate metabolites∑8m-PAEs).The concentration ranges of P8m-PAEs were 2.7-55 and 0.99-17 ng/mL in blood and semen samples,***(median,3.6 ng/mL in blood and 0.55 ng/mL in semen)and MnOP(median,3.4 ng/mL in blood and 0.69 ng/mL in semen)were the predominant analytes in both blood and semen ***,analytes were not correlated in paired blood and *** motility was significantly associated to the concentrations of∑8m-PAEs in semen,but it did not associate to the concentrations of PAEs in ***-linear regression analysis,including concentrations of PAEs in both blood and semen,as well as BMI,occupation,living habits,suggested that exposure to PAEs at current environmental levels had very limited effects on semen quality of population in Guangzhou,China.

关键词： Phthalate metabolites(m-PAEs) Whole blood semen concentration semen motility Pearl river delta region

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Correlation of testicular reproductive tumor related genes in semen of patients with testicular microlithiasis

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Food Therapy and Health Care 2021年第2期3卷 47-51页

作者： Chun-Xu Li Shao-Feng Chen Yuan Zhang Li-Feng Chen Qiang Geng Department of Urology Tianjin Medical University Second HospitalTianjin 300211China Department of Andrology First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Department of Pediatrics First Teaching Hospital of Tianjin University of Traditional Chinese MedicineTianjin 300193China Department of Physiology Basic Medical CollegeHebei North UniversityZhangjiakouHebei 075000China

Objective:To investigate the expression of testicular tumor-related genes in the semen of patients with microlithiasis,as well as the semen concentration in patients with ***:Retrospective analysis of 2018/6-2019/6 male in our hospital clinic examination of patients with testicular color to exceed,semen specimen were collected,30 patients with testicular micro stone disease group of 15 cases,control group in 15 cases,the process of semen automatic analyzer to detect sperm concentration,by rt-pcr and Western Blot respectively detect testicular cancer related gene(KITLG KIT ligand(gene),SPRY4(sprouty RTK signaling 4)antagonist)mRNA and protein ***:The semen concentration(17.31±0.92)×10-6/ml in the microstone group was lower than that in the control group(29.26±1.57)×10-6/*** mRNA expression of semen(KITLG,SPRY4)in the microstone group was higher than that in the control group,and the difference was statistically *** protein expression of semen(KITLG,SPRY4)in the microstone group was higher than that in the control group,and the difference was statistically ***:The semen concentration of testicular microlithiasis decreased,but the expression of seminal testicular tumor genes(KITLG,SPRY4)increased.

关键词： Testicular microlithiasis semen concentration Testicular malignancy related genes

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