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Different frequencies of electroacupuncture and semen coicis decrease glial fibrillary acidic protein expression in rats with hemisection spinal cord injury

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Neural Regeneration Research 2011年第24期6卷 1870-1875页

作者： Chunguang Hou Zhongzheng Li Yi Guo Yongming Guo Yangyang Liu Chao Wang Ishida Torao Experimental Acupuncture Research Center Tianjin University of Traditional Chinese Medicine Tianjin 300193 China Oriental Medicine Institute of Suzuka Medical Science College Kishiokachou Suzuka 1001-1 Japan

This study established the following groups of rats： a normal group, a sham surgery group, a spinal cord injury model group, a low-frequency electroacupuncture group, a high-frequency electroacupuncture group and a semen coicis group. In all but the normal and sham surgery groups the left half of Tlo was transected. Four hours after model induction, 5-Hz and 100-Hz electroacupuncture were used to stimulate the acupoints I-luantiao （GB 30）, Zusan/i （ST 36）, Zhiyan9 （DU 9） and Xuanshu （DU 5）, or crude extract from semen coicis was intraperitoneally injected, for 8 consecutive weeks. The results indicated that electroacupuncture stimulation and intraperitoneal injection of semen coicis improved the morphology of spinal cord tissue, promoted the recovery of motion-evoked potentials, suppressed glial fibrillary acidic protein expression, and ameliorated motor function in rats with hemisection spinal cord injury. The effects of high-frequency （100 Hz） electroacupuncture ancl semen coicis were significant.

关键词： electroacupuncture semen coicis hemisection spinal cord injury traditional Chinese medicine neural regeneration

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Hepatocellular carcinoma HepG2 cell apoptosis and caspase-8 and Bcl-2 expression induced by injectable seed extract of Coix lacryma-jobi

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Hepatobiliary & Pancreatic Diseases International 2011年第3期10卷 303-307页

作者： Department of General Surgery (Lu Y and Zhang BY),Department of Bio-Information (Jia ZX),Affiliated Medical College Hospital,Qingdao University,Qingdao 266003,China Shanghai Jiaotong University School of Medicine,Shanghai 200025,China (Wu WJ) Department of Medicine,Heze Medical College,Heze 274000,China (Lu ZQ) Department of General Surgery Affiliated Medical College Hospital Qingdao University Department of Bio-Information Affiliated Medical College Hospital Qingdao University

BACKGROUND:Many Chinese herbs,especially herbal injections,have been shown to have anti-tumor effects in recent ***,since most reports focus on the clinical effectiveness of these herbs,their mechanisms of action are not well *** this study,we assessed apoptosis in the hepatocellular carcinoma (HCC) cell line HepG2 induced by an injectable extract from the seed of Coix lacryma-jobi (semen coicis,SC),and monitored the expression of Bcl-2 and ***:Injectable SC was applied to HepG2 cells at different concentrations and the cells were collected 12,24 and 48 hours later.5-fluorouracil was used as a positive control group,and fluorescence-activated cell-sorting cytometry was used to measure the apoptosis rate of HepG2 cells and the expression of Bcl-2 and caspase-8 ***:SC induced apoptosis in HepG2 cells in a concentration and time-dependent manner,and the expression of caspase-8 was elevated and ***,it did not significantly influence the expression of ***:Injectable SC may induce apoptosis in HCC cells by regulating the expression of caspase-8.

关键词： semen coicis traditional Chinese medicine Bcl-2 caspase-8 HepG2 cells apoptosis

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Anti-Obesity Effects of Chang-Chul-Eui-Ee-ln-Tang(苍术薏苡仁汤) in Female Rats with Diet-Induced Obesity

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Chinese Journal of Integrative Medicine 2011年第12期17卷 925-932页

作者： Sunmin Park Jung Bok Lee James W.Daily Department of Food and Nutrition Obesity/Diabetes Research InstitutesHoseo UniversityAsan(336-795)South Korea Daily Manufacturing IncRockwellNC

Objective： To investigate the effects of Chang-ChuI-Eui-Ee-ln-Tang （苍术薏苡仁汤, CCEET）, modified CCEET （MCCEET）, and semen coicis （SC, a major component of CCEET） on energy and glucose homeostasis. The possible mechanism of action of CCEET was also determined. Methods： A total of 100 Sprague Dawley female rats were randomly assigned to 5 groups, with 20 in each group. Rats in 4 groups were fed with a high fat diet supplementation （2 g/kg body weight）, and water extracts of CCEET, MCCEET, SC, and cellulose （negative control）, respectively. The last group was fed with a low-fat diet as a positive control. Results： CCEET and MCCEET decreased body weight and body fat （mesenteric and retroperitoneal fat） more than SC. This decrease was due to decreased energy intake and increased energy expenditure and fat oxidation. The improvement in energy homeostasis was associated with the enhancement of the hypothalamic leptin signalling pathway involving potentiating the phosphorylation of the signal transducer and activator of transcription-3, as well as attenuating the phosphorylation of 5＇ adenosine monophosphate-activated protein kinase （AMPK）. Both CCEET and MCCEET improved glucose tolerance without changing serum insulin levels during an oral glucose tolerance test but MCCEET had a better effect than CCEET. Conclusions： Both CCEET and MCCEET safely exerted anti-obesity effects by enhancing energy balance in female rats with diet-induced obesity; MCCEET showed a better effect on glucose homeostasis.

关键词： Chang-ChuI-Eui-Ee-ln-Tang semen coicis leptin signal transducer and activator oftranscription-3 5' adenosine monophosphate-activated protein kinase hypothalamus

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