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Cyanobacteria-based near-infrared light-excited self-supplying oxygen system for enhanced photodynamic therapy of hypoxic tumors

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Nano Research 2021年第3期14卷 667-673页

作者： Yinghua Zhang Huifang Liu Xinyue Dai Hang Li Xiaohan Zhou Shizhu Chen Jinchao Zhang Xing-Jie Liang Zhenhua Li College of Chemistry&Environmental Science Analytical Chemistry Key Laboratory of Hebei ProvinceChemical Biology Key Laboratory of Hebei ProvinceHebei UniversityBaoding071002China Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education Institute of Life Science and Green DevelopmentHebei UniversityBaoding071002China College of Pharmaceutical Science Key Laboratory of Pharmaceutical Quality Control of Hebei ProvinceHebei UniversityBaoding071002China Beijing Pharmaceutical Group Company Limited Beijing100101China The National Institutes of Pharmaceutical R&D Co. Ltd.China Resources Pharmaceutical Group LimitedBeijing102206China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and TechnologyBeijing100190China

Tumor hypoxia has been considered to induce tumor cell resistance to radiotherapy and anticancer chemotherapy,as well as predisposing for increased tumor metastases.Therefore,strategies for the eradication of the hypoxic tumor are highly desirable.Photodynamic therapy(PDT)is a new technique that can be used to treat tumors using laser irradiation to photochemically activate a photosensitizer.Compared to traditional radiotherapy and chemotherapy,photodynamic therapy has many advantages,such as good selectivity,low toxicity,and less trauma and resistance.However,PDT is oxygen-dependent,and the lack of oxygen in hypoxic tumors renders photodynamic therapy ineffective.Cyanobacteria,the earliest photosynthetic oxygen-generating organisms,can utilize water as an electron donor to reduce CO_(2) into organic carbon compounds along with continuously releasing oxygen under sunlight.Inspired by this,herein,cyanobacteria were used as a living carrier of photosensitizer conjugated upconversion nanoparticles(UCNP)to construct a self-supplying oxygen PDT system.Improvement in the PDT efficiency for hypoxic tumors can be achieved as a result of in situ oxygen production by cyanobacteria under near-infrared(NIR)light using UCNP as a light harvesting antenna.A successful demonstration of this concept would be of great significance and could open the door to a new generation of carrier systems in the field of hypoxia-targeted drug transport platforms.

关键词： self-supplying oxygen cyanobacteria hypoxic tumor photodynamic therapy upconversion nanoparticles

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