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Molecular mechanisms of anti-cancer bioactivities of seaweed polysaccharides

Chinese Herbal Medicines 2022年第4期14卷 528-534页

作者： Tingting Liu Qing Li Xu Xu Guoxia Li Chengwang Tian Tiejun Zhang School of Basic Medicine Tianjin Medical UniversityTianjin 300070China Tianjin Pharmaceutical Research Institute Tianjin 300462China State Key Laboratory of Drug Release Technology and Pharmacokinetics Tianjin 300462China Research Unit for Drug Metabolism Chinese Academy of Medical SciencesTianjin 300462China

seaweed is a traditional Chinese medicine homologous to food,in which polysaccharides are responsible for anti-cancer by enhancing immunity,inducing cancer cell apoptosis,inhibiting cancer cell invasion and metastasis or directly scavenging oxidative free radicals that induce cancer cell *** them,regulating immunity and promoting cancer cell apoptosis are intensively studied due to the important role in preventing *** we reviewed seaweed in the apoptosis-inducing signaling pathways including PI3K/AKT,ROS and JNK and discussed challenges in studying seaweed.

关键词： anti-cancer apoptosis immunomodulation seaweed polysaccharides signal pathways

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seaweed polysaccharide fibers:Solution properties,processing and applications

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Journal of Materials Science & Technology 2023年第9期140卷 1-18页

作者： Junping Ju Jinzhu Yang Wenchao Zhang Yuting Wei Hua Yuan Yeqiang Tan State Key Laboratory of Bio-Fibers and Eco-Textiles&Institute of Marine Biobased Materials&Collage of Materials Science and Engineering Qingdao UniversityQingdao 266071China

seaweed polysaccharides with abundantly renewable sources and charming properties have attracted arising ***,carrageenan and agar with the largest are the most predominant species of common seaweed *** review will first provide a comprehensive overview of general information on seaweed polysaccharides regarding solubility,multilevel structure,viscoelasticity,and *** we summarize preparation methods of seaweed polysaccharides fibers including wet-spinning technique,electrospinning technique and microfluidic *** applications of seaweed polysaccha-rides fibers,based on many excellent inherent properties,including biocompatibility,suitable microstruc-ture,nontoxicity,potential bioactivity,good intrinsic flame retardancy and thermal stability,are described in detail.

关键词： seaweed polysaccharides Solution characteristics Fibers Applications

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Effects of Enteromorpha prolifera polysaccharides on growth performance,intestinal barrier function and cecal microbiota in yellow-feathered broilers under heat stress

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Journal of Animal Science and Biotechnology 2024年第1期15卷 344-361页

作者： Wenchao Liu Huimei Liu Yaoyao Wang Zhongxiang Zhao Balamuralikrishnan Balasubramanian Rajesh Jha Department of Animal Science College of Coastal Agricultural SciencesGuangdong Ocean UniversityZhanjiangGuangdong 524088People’s Republic of China Department of Food Science and Biotechnology College of Life ScienceSejong UniversitySeoul 05006South Korea Department of Human Nutrition Food and Animal SciencesCollege of Tropical Agriculture and Human ResourcesUniversity of Hawaii at ManoaHonoluluHI 96822USA

Background Global warming leading to heat stress(HS)is becoming a major challenge for broiler *** study aimed to explore the protective effects of seaweed(Enteromorpha prolifera)polysaccharides(EPS)on the intestinal barrier function,microbial ecology,and performance of broilers under HS.A total of 144 yellow-feathered broilers(male,56 days old)with 682.59±7.38 g were randomly assigned to 3 groups:1)TN(thermal neutral zone,23.6±1.8℃),2)HS(heat stress,33.2±1.5℃ for 10 h/d),and 3)HSE(HS+0.1%EPS).Each group contained 6 replicates with 8 broilers per *** study was conducted for 4 weeks;feed intake and body weights were measured at the end of weeks 2 and *** the end of the feeding trial,small intestine samples were collected for histomorphology,antioxidant,secretory immunoglobulin A(s Ig A)content,apoptosis,gene and protein expression analysis;cecal contents were also collected for microbiota analysis based on 16S r DNA *** Dietary EPS promoted the average daily gain(ADG)of broilers during 3–4 weeks of HS(P<0.05).At the end of HS on broilers,the activity of total superoxide dismutase(T-SOD),glutathione S-transferase(GST),and the content of s Ig A in jejunum were improved by EPS supplementation(P<0.05).Besides,dietary EPS reduced the epithelial cell apoptosis of jejunum and ileum in heat-stressed broilers(P<0.05).Addition of EPS in HS group broilers'diet upregulated the relative m RNA expression of Occludin,ZO-1,γ-GCLc and IL-10 of the jejunum(P<0.05),whereas downregulated the relative m RNA expression of NF-κB p65,TNF-αand IL-1βof the jejunum(P<0.05).Dietary EPS increased the protein expression of Occludin and ZO-1,whereas it reduced the protein expression of NF-κB p65 and MLCK(P<0.01)and tended to decrease the protein expression of TNF-α(P=0.094)in heat-stressed ***,the proportions of Bacteroides and Oscillospira among the three groups were positively associated with jejunal apoptosis and pro-inflammatory cytokine ex

关键词： Broilers Cecal microbiota Heat stress Intestinal barrier function seaweed polysaccharides

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