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Analysis of Patent Application Status of scutellaria barbata Industrial Chain Based on Patent Data

Asian Journal of Social Pharmacy 2024年第1期19卷 89-97页

作者： Zeng Yingying Liu Tong Liu Yue Song Aiwei Yuan Hongmei School of Business Administration Shenyang Pharmaceutical University2.Liaoning Institute for Drug ControlShenyang Shenyang 110016China

Objective To analyze patent application status of scutellaria barbata industrial chain and provide some suggestions for its patent application and product *** Patent data were collected through IncoPat patent analysis ***,the patent analysis method combined with text mining method was adopted to analyze the situation and development trend of patent application in China’s scutellaria barbata industrial chain by using pie chart,bubble chart,trend chart and other visual charts to display the *** and Conclusion The patent application of scutellaria barbata in China mainly experienced three stages:Slow development,rapid development,and recession *** number of patents is large,but the authorization rate is *** and enterprises are the main applicants for patent *** development is involved in the whole industrial chain,but it basically focuses on its efficacy in downstream drugs,health food and other ***,government should enhance the awareness of patent protection,encourage collaborative innovation in industry-university-research to promote the combination of basic research and market ***,it should provide theoretical support to tackle the problem of short board products,which can promote the transformation of scientific and technological achievements and contribute to the upgrading of scutellaria barbata industrial chain.

关键词： scutellaria barbata patent industrial chain

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scutellaria barbata attenuates diabetic retinopathy by preventing retinal inflammation and the decreased expression of tight junction protein

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 870-877页

作者： Xi-Yu Mei Ling-Yu Zhou Tian-Yu Zhang Bin Lu Li-Li Ji The MOE Key Laboratory for Standardization of Chinese Medicines Shanghai Key Laboratory of Complex Prescription Institute of Chinese Materia Medica Shanghai University of Traditional Chinese Medicine Shanghai 201203 China

AIM： To observe the attenuation of ethanol extract of Herba scutellaria barbata （SE） against diabetic retinopathy （DR） and its engaged mechanism. METHODS： C57BL/6J mice were intraperitoneally injected with streptozotocin （STZ, 55 mg/kg） for 5 consecutive days to induce diabetes, The diabetic mice were orally given with SE （100, 200 mg/kg） for lmo at lmo after STZ injection. Blood-retinal barrier （BRB） breakdown was detected by using Evans blue permeation assay. Real-time polymerase chain reaction （RT-PCR）, Western blot and immunofiuorescence staining were used to detect mRNA and protein expression. Enzyme-linked immunosorbent assay （ELISA） was used to detect serum contents of tumor necrosis factor-e （TNF-a） and interleukin （IL）-II. RESULTS： SE （100, 200 mg/kg） reversed the breakdown of BRB in STZ-induced diabetic mice. The decreased expression of retinal claudin-1 and claudin-19, which are both tight junction （T J） proteins, was reversed by SE. SE decreased the increased serum contents and retinal mRNA expression of TNF-a and IL-113. SE also decreased the increased retinal expression of intercellular cell adhesion molecule-1 （ICAM-1）. SE reduced the increased phosphorylation of nuclear factor kappa B （NFKB） p65 and its subsequent nuclear translocation in retinas from STZ- induced diabetic mice. Results of Western blot and retinal immunofluorescence staining of ionized calcium-binding adapter molecule 1 （Ibal） demonstrated that SE abrogated the activation of microglia cells in STZ-induced diabetic mice. CONCLUSION： SE attenuates the development of DR by inhibiting retinal inflammation and restoring the decreased expression of TJ proteins including claudin-1 and claudin-19.

关键词： scutellaria barbata diabetic retinopathy tightjunction inflammation nuclear factor kappa B microglia

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Two New neo-Clerodane Diterpenoids from scutellaria barbata

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Journal of Integrative Plant Biology 2008年第6期50卷 699-702页

作者： Sheng-Jun Dai Li Shen Yan Ren School of Pharmaceutical Science Yantai University Yantai 264005 China

Two new neo-clerodane diterpenoids, 6,7-dibenzoyloxybarbatin C （1, named barbatin D） and 6-（2-acetoxy-3-methylbutanoloxy）-7-（2-carbonyl-3-methylbutanoyloxy） barbatin C （2, named barbatin E） were isolated from the whole plant of scutellaria barbata D. Don. Their structures were elucidated by spectroscopic methods including extensive 1 D and 2D NMR analyses. In vitro, compounds 1-2 showed cytotoxic activities against three human cancer lines, namely, HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells, and with IC50 values in the range of 3.5-6.7μM.

关键词： barbatin D barbatin E cytotoxic activity neo-clerodane diterpenoid scutellaria barbata

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Chemical profiling of scutellaria barbata by ultra high performance liquid chromatography coupled with hybrid quadrupole-orbitrap mass spectrometry

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Journal of Chinese Pharmaceutical Sciences 2015年第10期24卷 635-646页

作者：李茹宋玮乔雪刘佳梁鸿叶敏北京大学药学院天然药物及仿生药物国家重点实验室北京100191 北京大学基础医学院系统生物学研究所北京100191

An ultra high performance liquid chromatography coupled with hybrid quadrupole-orbitrap mass spectrometry （UHPLC-quadrupole-orbitrap MS） method was developed to systematically analyze chemical constituents of scutellaria barbata D. Don. The 70% methanol extract was separated on an Agilent Eclipse Plus Cl8 column （1.8μm, 150 mm×2.1 mm）, and eluted with a gradient of methanol-acetonitrile-water containing 0.1% formic acid at a flow rate of 0.25 mL/min. Constituents were identified by HRMS in the negative ion mode using both full scan and two-stage threshold-triggered mass modes. A total of 56 compounds, including 20 free flavonoids, 20 flavonoid O-glycosides, 2 flavonoid C-glycosides, 4 phenylethanoid glycosides, and 10 phenolic compounds were identified by analyzing their high resolution mass spectral data. Among them, 8 flavonoids and 2 phenylethanoid glycosides were unambiguously identified by comparing with reference standards. This study demonstrates that hybrid quadrupole-orbitrap mass spectrometry is a powerful tool in structural identification of unknown compounds in comolicated herbal extracts.

关键词： scutellaria barbata Chemical analysis Quadrupole-orbitrap mass spectrometry Flavonoids

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The genomes of medicinal skullcaps reveal the polyphyletic origins of clerodane diterpene biosynthesis in the family Lamiaceae

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Molecular Plant 2023年第3期16卷 549-570页

作者： Haixiu Li Song Wu Ruoxi Lin Yiren Xiao Ana Luisa Malaco Morotti Ya Wang Meytal Galilee Haowen Qin Tao Huang Yong Zhao Xun Zhou Jun Yang Qing Zhao Angelos K.Kanellis Cathie Martin Evangelos C.Tatsis National Key Laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China University of Chinese Academy of Sciences Beijing 100049China Novogene Bioinformatics Institute BeijingChina Shanghai Key Laboratory of Plant Functional Genomics and Resources Shanghai Chenshan Botanical GardenShanghai Chenshan Plant Science Research CenterChinese Academy of SciencesShanghai 201602 Group of Biotechnology of Pharmaceutical Plants Lab.of PharmacognosyDepartment of Pharmaceutical SciencesAristotle University of Thessaloniki54124 ThessalonikiGreece John Innes Centre Norwich NR47UHUK CEPAMS-CAS-JIC Centre of Excellence for Plant and Microbial Sciences Shanghai 200032China

The presence of anticancer clerodane diterpenoids is a chemotaxonomic marker for the traditional Chinese medicinal plant scutellaria barbata,although the molecular mechanisms behind clerodane biosynthesis are ***,we report a high-quality assembly of the 414.98 Mb genome of *** into 13 *** phylogenomic and biochemical data,we mapped the plastidial metabolism of kaurene(gibberellins),abietane,and clerodane diterpenes in three species of the family Lamiaceae(scutellaria barbata,scutellaria baicalensis,and Salvia splendens),facilitating the identification of genes involved in the biosynthesis of the clerodanes,kolavenol,and *** show that clerodane biosynthesis evolved through recruitment and neofunctionalization of genes from gibberellin and abietane *** the assumed monophyletic origin of clerodane biosynthesis,which is widespread in species of the Lamiaceae,our data show distinct evolutionary lineages and suggest polyphyletic origins of clerodane biosynthesis in the family *** study not only provides significant insights into the evolution of clerodane biosynthetic pathways in the mint family,Lamiaceae,but also will facilitate the production of anticancer clerodanes through future metabolic engineering efforts.

关键词： scutellaria barbata genome clerodane diterpenoids biosynthesis specialized metabolism evolution

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Study on Infrared Fingerprint of Sculellaria brbata

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Agricultural Science & Technology 2017年第12期18卷 2561-2562页

作者：李吉锋渭南师范学院化学与材料学院陕西渭南714099 陕西省河流湿地生态环境重点实验室陕西渭南714099

[Objective] This study was conducted to establish the characteristic finger- prints of herbal materials in the Weinan section of the Yellow River Wetland. [Method] scutellaria barbata materials were collected from the Weinan section of the Yellow River Wetland. Fingerprint analysis was performed using their mid-IR spectra, and an IR fingerprint analysis method of S. barbata was established.[Result] The four collected S. barbata materials had basically the same IR finger- print characteristics, [Conclusion] S. barbata was identified by IR fingerprint method, and FTIR could serve as a rapid and scientific detection means for macro-control of S. barbata materials.

关键词： scutellaria barbata Infrared Fingerprint Detection

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