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Repetitive transcranial magnetic stimulation for hallucination in schizophrenia spectrum disorders A meta-analysis

Neural Regeneration Research 2013年第28期8卷 2666-2676页

作者： Yingli Zhang Wei Liang Shichang Yang Ping Dai Lijuan Shen Changhong Wang Psychological Counseling Center Second Affiliated Hospital of Xinxiang Medical University Department of Clinical Psychology Second Affiliated Hospital of Xinxiang Medical University Department of Psychology Xinxiang Medical University Library of Sichuan University Mental Health Institute Second Xiangya HospitalCentral South University Department of Psychiatry Second Affiliated Hospital of Xinxiang Medical University

OBJECTIVE： This study assessed the efficacy and tolerability of repetitive transcranial magnetic stimulation for treatment of auditory hallucination of patients with schizophrenia spectrum disorders. DATA SOURCES： Online literature retrieval was conducted using PubMed, ISI Web of Science, EMBASE, Medline and Cochrane Central Register of Controlled Trials databases from January 1985 to May 2012. Key words were ＂transcranial magnetic stimulation＂, ＂TMS＂, ＂repetitive tran- scranial magnetic stimulation＂, and ＂hallucination＂. STUDY SELECTION： Selected studies were randomized controlled trials assessing therapeutic ef- ficacy of repetitive transcranial magnetic stimulation for hallucination in patients with schizophrenia spectrum disorders. Experimental intervention was low-frequency repetitive transcranial magnetic stimulation in left temporoparietal cortex for treatment of auditory hallucination in schizophrenia spectrum disorders. Control groups received sham stimulation. MAIN OUTCOME MEASURES： The primary outcome was total scores of Auditory Hallucinations Rating Scale, Auditory Hallucination Subscale of Psychotic Symptom Rating Scale, Positive and Negative Symptom Scale-Auditory Hallucination item, and Hallucination Change Scale. Secondary outcomes included response rate, global mental state, adverse effects and cognitive function. RESULTS： Seventeen studies addressing repetitive transcranial magnetic stimulation for treatment of schizophrenia spectrum disorders were screened, with controls receiving sham stimulation. All data were completely effective, involving 398 patients. Overall mean weighted effect size for repeti- tive transcranial magnetic stimulation versus sham stimulation was statistically significant （MD = -0.42, 95%C/： -0.64 to -0.20, P = 0.000 2）. Patients receiving repetitive transcranial magnetic stimulation responded more frequently than sham stimulation （OR = 2.94, 95%C/： 1.39 to 6.24, P =0.005）. No significant differences were found between active repetitive transcranial magnetic stimulation a

关键词： neural regeneration meta-analysis transcranial magnetic stimulation auditory hallucination schizophre-nia schizophrenia spectrum disorders schizophreniform disorder temporoparietal cortex cognitive func-tion positive symptom grants-supported paper neuroregeneration

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Acupuncture treatment of a male patient suffering from long-term schizophrenia and sleep disorders

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Journal of Traditional Chinese Medicine 2017年第6期37卷 862-867页

作者： Peggy Bosch Heike Staudte Sujung Yeo Sook-Hyun Lee Sabina Lim Maurits van den Noort Donders Centre for Cognition Radboud University NijmegenNijmegen 6525 HRThe Netherlands Psychiatric Research Institute LVR-Klinik Bedburg-HauBed-burg-Hau 47551Germany Psychiatric Research Institute LVR-Klinik Bedburg-HauBedburg-Hau 47551Germany Department of Acupuncture&Meridian of Oriental Medicine Sang Ji UniversityWonju 26339Republic ofKorea Research Group of Pain and Neuroscience Kyung Hee UniversitySeoul 130-701Republic of Korea Research Group of Pain and Neuro-science Kyung Hee UniversitySeoul 130-701Republic of Korea.Brussels Institute for Applied LinguisticsFree Univer-sity of BrusselsBrussels 1050Belgium

OBJECTIVE: To investigate the effectiveness of acupuncture in the treatment of chronic schizophrenia and co-morbid sleep disorders.METHODS: A 42-year-old German male outpatient,suffering from long-term schizophrenia and sleep disorders, entered the study. Acupuncture was used as a non-pharmacological intervention. In addition to his ongoing Western Medicine(pharmacological) treatment, the patient received 12 weekly(non-standardized) acupuncture treatments in the clinic. The Traditional Chinese Medicine(TCM) diagnosis, the psychological assessment and the actiwatch data were compared before and after the acupuncture treatment.RESULTS: The TCM diagnosis revealed a Liver Fire pattern before the acupuncture treatment, which was still present, although to a lesser degree, after the treatment. The psychological assessment revealed no change in the positive symptoms, but a small decrease in the negative symptoms and the general psychopathology of the patient. This was further illustrated by the small decrease in the number of depressive symptoms. The subjective sleep disorders improved markedly after acupuncture treatment, but the daytime sleepiness did not. The actiwatch results showed that after acupuncture treatment, the patient was moving less during sleep, but no significant results were found for the other sleep parameters.CONCLUSION: Acupuncture was found to be an effective non-pharmacological add-on method for treating subjective sleep disorders, and, to a lesser degree, objective sleep disorders and the negative symptoms of chronic schizophrenia. Future larger clinical trials with follow-up measurements are needed in order to replicate the present preliminary beneficial acupuncture findings and in order to determine whether the observed effects can be sustained.

关键词： Actigraphy Acupuncture schizophre-nia Sleep weak disorders

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Psychobiological Model of Volition— Implications for Mental Disorders

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Open Journal of Medical Psychology 2020年第2期9卷 50-69页

作者： Bernhard Mitterauer University of Salzburg Volitronics-Institute for Basic Research WALS Salzburg Austria

A new psychobiological model of volitive processes and its implications for the etiopathology of mental disorders is proposed. The model is based on five elementary volitive processes. These are the volition to act;the volition to self-instrumentalize;the volition to program intentions, the volition to generate realities;and the volition to permanent existence. Imbalances in information processing in tripartite synapses and their network may be responsible for dysfunctions of self-instrumentalization. It is suggested that the volition to permanent existence unconsciously works in mental disorders, but the volition to intentional programming of realities and the volition to generate realities by communication with subjects and objects in their environment are impaired. In depression, the volition to act is constrained by hyperintentional programs that are non-feasible in the environment. In mania volitive processes are totally oriented on events in the environment without any goal-directed pro-gramming. Dysfunctions of volitive processes in schizophrenia are fun-damentally caused by severe impairments of self-instrumentalization. As shown in tripartite synapses a gap between sensory information pro-cessing in the neuronal network and the inner glial networks causes the inability of schizophrenics to distinguish between the self and the other. In delusions, the destiny for communication becomes staged as pseu-do-communication. Together, the study outlines a new model of volitive processes and deduces dysfunctions responsible for communication pa-thology and abnormal reality experiences of patients with mental disor-ders.

关键词： Model of Volition Disorders of Volition Depression Mania schizophre-nia

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