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scanning photoacoustic imaging of submucosal gastric tumor based on a long focused transducer in phantom and in vitro experiments

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Journal of Innovative Optical Health Sciences 2019年第3期12卷 55-66页

作者： Hua-Qin Wu Hao-Yu Wang Wen-Ming Xie Shu-Lian Wu Zhi-Fang Li Xiao-Man Zhang Hui Li Key Laboratory of Optoelectronic Science and Technology for Medicine Ministry of Education Fujian Provincial Key Lab of Photonic Technology College of Photonic and Electronic Engineering Fujian Normal University Fuzhou 350007FujianP.R.China

photoacoustic imaging,which can provide the maximum intensity contrast in tissue depth imaging without ionizing radiation,will be a promising imaging trend for tumor *** this paper,a column diffusionfiber was employed to carry a pulsed laser for irradiating stomach directly through esophagus based on the characteristics of gastric tissue structure.A long focused ultrasonic transducer was placed outside the body to detect photoacoustic signals of gastric *** and in vitro experiments of submucosal gastric tumors were carried out to check the sensitivity of scanning photoacoustic tomography system,including the lateral and longitudinal resolution of the system,sensitivity of different absorption coefficient in imaging,capability of transversal detection,and probability of longitudinal *** results demonstrate that our innovative technique can improve the parameters of *** lateral resolution reaches 2.09 *** a depth of 5.5mm with a longitudinal accuracy of 0.36mm below gastric mucosa of early gastric cancer(EGC)has been *** addition,the optimal absorption coefficient differences among absorbers of system are 3.3-3.9 *** indicate that our photoacoustic imaging(PAI)system,is based on a long focusing transducer,can provide a potential application for detecting submucosal EGC without obvious symptoms.

关键词： Column diffusionfiber long focusing transducer gastric tumor detection scanning photoacoustic tomography phantom experiment

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