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Origami meets electrospinning:a new strategy for 3D nanofiber scaffolds

Bio-Design and Manufacturing 2018年第4期1卷 254-264页

作者： Juqing Song Guanglin Zhu Huichang Gao Lin Wang Nanying Li Xuetao Shi Yingjun Wang National Engineering Research Centre for Tissue Restoration and Reconstruction South China University of Technology Guangzhou 510006People's Republic of China Department of Biomedical Engineering School of Materials Science and EngineeringSouth China University of TechnologyGuangzhou 510006People's Republic of China School of Medicine South China University of TechnologyGuangzhou 510006People's Republic of China

Inspired by the constitution of things in the natural world,three-dimensional (3D)nanofiber scaffold/cells complex was constructed via the combination of electrospinning technology and origami *** nanofiber boxes prepared by origami provided a limited space for the layer-by-layer nanofiber films,and the human fetal osteoblasts (hFOBs)seeded on the both sides of the nanofiber films were expected to facilitate the bonding,of the adjacent nanofiber films through the secretion of extracellular ***,the hFOBs presented 3D distribution in the nanofiber scaffold,and they can stretch across the gaps between the adjacent nanofiber films,forming the cell layers and filling the whole 3D nanofiber ***,a 3D block composed of electrospun nanofiber scaffold and cells was obtained',which possesses potential applications in bone tissue ***,we also created 3D nanofiber structures that range from simple forms to intricate architectures via origami,indicating that the combination of electrospinning technology and origami techniques is a feasible method for the 3D construction of tissue engineering scaffolds.

关键词： Electrospinning Origami 3D construction Nanofiber scaffold/cells complex

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