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Antiplasmodial and antiulcer activities of Melanthera scadens

Asian Pacific Journal of Tropical Biomedicine 2012年第1期2卷 16-20页

作者： Jude E Okokon Ette O Etebong John A Udobang Jackson Obot Department of Pharmacology and Toxicology Faculty of PharmacyUniversity of Uyo

Objective:To evaluate the antimalarial and antiulcerogenic activities ofleaf exlracl and fractions of Melanthera scandens(***).Methods:The crude leaf extract(37-111 mg/kg)and fractions(chloroform,ethylacetale and methanol;78 mg/kg)of *** were investigated for antiplasmodial activity against chloroquine-sensitive Plasmodium berghei infections in mice and for antiulcer activity against experimentally-induced *** antimalarial activity during early and established infections as well as prophylactic was ***(5 mg/kg)and pyrimethamine(1.2 mg/kg)were used as positive *** films made from tail blood of each mouse were used to assess the level of parasitaemia of the *** activity of the crude extract was also evaluated against indomethacin,ethanol and histamine induced ***:The extract and its fractions dose-dependently reduced parasitaemia induced by chloroquine-sensitive Plasmodium berghei infection in prophylactic,suppressive and curative models in *** reductions were statistically significant(P<0.00l),They also improved the mean survival time(MST)from 9.28 to 17.73 days as compared with the control(P<0.0l-0.001).The activities of extract/fractions were incomparable to that of the standard drugs *** and *** experimentally-induced ulcers,the extract inhibited indomethacin,ethanol and histamine induced *** inhibitions were statistically significant(P<0.001)and in a dose-dependent ***:The antiplasmodial and antiulcerogenic effects of this plant may in part be mediated through the chemical constituents of the plant.

关键词： Melanthera scadens Antiplasmodial activity Antiulcer activity Antimalarial activity Antiulcerogenic activity Chemical constituent Parasitaemia Plasmodium berghei Artesunate Indomethacin Pyrimethamine

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