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Diet Rich in saturated fat Decreases the Ratio of Thromboxane/prostacyclin in Healthy Men

Biomedical and Environmental Sciences 2003年第4期16卷 333-339页

作者： DuoLI RAYMUNDOHABITO GEORGEANGELOS[ ANDREWJ.SINCLAIR ANDMADELEINEJ.BALL DepartmentofFoodScience HangzhouUniversityofCommerceHangzhou310035ZhejiangChina DepartmentofBiomedicalScience UniversityofTasmaniaTASAustralia 9epartmentofFoodScience RMITUniversityMelbourneV1CAustralia

Objective To investigate the effect of dietary saturated fat (SFA) from animal sources on the urine excretion 11-dehydro thromboxane 62 (TXB2) and 6-keto prostaglandin F la (PGF la) in 27 healthy free-living male subjects aged 30 to 55 years. Methods It was a randomized crossover design. Each volunteer was randomly assigned to one of the two diets (high fat and low fat) for a period of 4 weeks, after which each subject resumed his usual diet for 2 weeks as a 'wash-out period', before being assigned to the other diet for an additional 4 weeks. Results Serum proportion of 20:4n-6 was 5% lower in the high fat (6.2% of total fatty acid) than in the low fat diet (6.5% of total fatty acid), which was associated with a significantly decreased ratio of the urinary excretion 11-dehydro TXB2 to 6-keto PGF lα (P<0.05). However, there was no significant fall in the absolute urinary excretion of 11-dehydro TXB2. Conclusions Diet rich in SFA from animal sources may influence TXA2 formation via effect on tissue proportion of 20:4n-6.

关键词： Thromboxane A2 Prostacyclin I2 Crossover saturated fat fatty acids

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Assessing the impact of concurrent high-fructose and highsaturated fat diets on pediatric metabolic syndrome:A review

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World Journal of Clinical Pediatrics 2024年第2期13卷 62-79页

作者： Manuel Alejandro Vargas-Vargas Marcela González-Montoya Olin Torres-Isidro Claudia Isabel García-Berumen Omar Ortiz-Avila Elizabeth Calderón-Cortés Christian Cortés-Rojo Instituto de Investigaciones Químico–Biológicas Universidad Michoacana de San Nicolás de HidalgoMorelia 58030MichoacánMexico Facultad de Enfermería Universidad Michoacana de San Nicolás de HidalgoMorelia 58020MichoacánMexico

High-saturated fat(HF)or high-fructose(HFr)consumption in children predispose them to metabolic syndrome(MetS).In rodent models of MetS,diets containing individually HF or HFr lead to a variable degree of ***,simultaneous intake of HF plus HFr have synergistic effects,worsening MetS *** children,the effects of HF or HFr intake usually have been addressed ***,we have reviewed the outcomes of HF or HFr diets in children,and we compare them with the effects reported in *** humans,HFr intake causes increased lipogenesis,hypertriglyceridemia,obesity and insulin *** the other hand,HF diets promote low grade-inflammation,obesity,insulin *** the deleterious effects of simultaneous HF plus HFr intake on MetS development in rodents,there is little information about the combined effects of HF plus HFr intake in *** aim of this review is to warn about this issue,as individually addressing the effects produced by HF or HFr may underestimate the severity of the outcomes of Western diet intake in the pediatric *** consider that this is an alarming issue that needs to be assessed,as the simultaneous intake of HF plus HFr is common on fast food menus.

关键词： Fructose saturated fat Metabolic syndrome Insulin resistance Type 2 diabetes Ultra processed foods Children Obesity Dyslipidemia Non-alcoholic fatty liver disease

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fatty Acid Expert Roundtable:Key Statements about fatty Acids

Fatty Acid Expert Roundtable:Key Statements about Fatty Acid...

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作者： K.C.Hayes

fatTY ACID ROUNDTABLE:FOREWORD On September 18,2008,a multidisciplinary panel of nutrition and clinical experts was convened to review the science regarding possible trans-fat replacement options and to discuss the im... 详细信息

关键词： saturated fat stearic acid trans-fat replacement

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Palm Oil and Health:A Case of Manipulated Perception and Misuse of Science

Palm Oil and Health:A Case of Manipulated Perception and Mis...

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作者： Donald J.McNamara Eggs for Health Consulting WashingtonDC

In the 1980s,a combination of forces came together to convince the public that food products containing tropical oils contributed to their risk of coronary heart *** oils were competing with the *** bean oil market as an alternative vegetable oil,yet they were higher in saturated fat,which had become the target of the health promotion community for its theoretical association with coronary heart disease *** national campaigns were undertaken to force food manufacturers to remove tropical oils,including palm oil, from their products and to replace them with hydrogenated vegetable oils,resulting in increased intakes of transfatty acids,which later became the target of the same advocacy *** palm oil is being touted as a suitable replacement for hydrogenated vegetable oils.

关键词： palm oil saturated fat tropical oil hydrogenated vegetable oil trans-fat

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