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Visualizing the spatial distribution and alteration of metabolites in continuously cropped salvia miltiorrhiza bge using MALDI-MSI

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Journal of Pharmaceutical Analysis 2022年第5期12卷 719-724页

作者： Chenglong Sun Li Cui Bingqian Zhou Xiao Wang Lanping Guo Wei Liu School of Pharmaceutical Sciences Qilu University of Technology(Shandong Academy of Sciences)Jinan250014China Key Laboratory for Applied Technology of Sophisticated Analytical Instruments of Shandong Province Shandong Analysis and Test CenterQilu University of Technology(Shandong Academy of Sciences)Jinan250014China Resource Center of Chinese Materia Medica State Key Laboratory Breeding Base of Dao-di HerbsChina Academy of Chinese Medical SciencesBeijing100700China

salvia miltiorrhiza bge(SMB)has long been used in traditional Chinese medicine to treat cardiovascular and cerebrovascular *** clinical usage has led to a huge demand for artificial planting of ***,continuous cropping of SMB is an important challenge that needs to be *** cropping can alter the metabolic profile of plants,resulting in poor growth and low *** this study,we tried to image the spatial location and variation of endogenous metabolites in continuously cropped SMB using matrix-assisted laser desorption/ionization mass spectrometry imaging(MALDIMSI).Spatially resolved expressions of tanshinones,salvianolic acids,polyamines,phenolic acids,amino acids,and oligosaccharides in normal and continuously cropped SMB roots were *** expressions of dihydrotanshinone Ⅰ,tanshinone Ⅱ A,dehydromiltirone,miltirone,dehydrotanshinone ⅡA,spermine,salvianolic acid B/E,tetrasaccharide,and pentasaccharide in continuously cropped SMB roots were much lower than those in normal *** was little difference in the expressions of caffeic acid and salvianolic acid A in normal and continuously cropped SMB *** acid was more widely distributed in xylem of normal SMB but strongly expressed in xylem,phloem,and cambium of continuously cropped *** spatially resolved metabolite information enhances our understanding of the metabolic signature of continuously cropped SMB and also provides insights into the metabolic effects of continuous cropping in other plants.

关键词： Metabolites Spatial distribution and alteration Continuous cropping salvia miltiorrhiza bge MALDI-MSI

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Protective effect and possible mechanisms of salvia miltiorrhiza bge. for the treatment of diabetic nephropathy: A systematic review and meta-analysis of animal studies

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Journal of Traditional Chinese Medical Sciences 2022年第4期9卷 351-364页

作者： Tingting Jiao Yunhua Liu Mei Han Sitong Wang Xinjiang Zhang Xinxue Zhang Zongjiang Zhao School of Traditional Chinese Medicine Beijing University of Chinese MedicineBeijing102488China Centre for Evidence-Based Chinese Medicine Beijing University of Chinese MedicineBeijing102488China

Objective:To explore the protective effect and potential mechanisms of danshen root(salvia miltiorrhiza bge.,***) and its extracts for the treatment of diabetic nephropathy(DN).Methods:Preclinical studies of *** and its extracts on DN were systematically searched in nine *** primary outcomes were blood glucose,kidney function,proteinuria,and renal *** secondary outcomes included the related *** methodological quality of animal studies was assessed based on the risk of bias tool of the Systematic Review Centre for Laboratory Animal Experimentation(SYRCLE) for animal ***-analysis was performed using R software(version 4.1.2).Results:Twenty-nine animal experimental studies that met the eligibility criteria were included in this *** to the control group,*** reduced the serum creatinine,blood urea nitrogen,24-h urine protein,24-h urine albumin,blood glucose,and kidney index(kidney weight/body weight),and alleviated renal pathological *** terms of the mechanism of action,compared to the control group,*** reduced the levels of transforming growth factor β1,collagen Ⅳ,malondialdehyde,tumor necrosis factor α,interleukin-6,and monocyte/macrophage(ED-1),and increased the levels of superoxide dismutase,glutathione peroxidase,nuclear factor E2-related factor 2,and heme ***:The existing evidence shows that *** has beneficial effects on the animal model of DN,and its mechanism is mainly related to improving kidney fibrosis,oxidative stress,and inflammatory response.

关键词： salvia miltiorrhiza bge Diabetic nephropathy Animal models Systematic review Meta-analysis

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Effect of salvia miltiorrhiza bge on Left Ventricular Hypertrophy and the Expression of Tumor Necrosis Factor-α in Spontaneously Hypertensive Rats

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2007年第3期27卷 245-247页

作者：孙联平郑智 Department of Emergency Medicine Bejing Chuiyangliu Hospital Department of Emergency Medicine Tongji Hospital Tongji Medical College Huazhong University of Science and Technology

The effects of salvia miltiorrhiza bge (SMB) on left ventricular hypertrophy (LVH) and the expression of tumor necrosis factor-α (TNF-α) in the left ventricle of spontaneously hypertensive rats and the action mechanism were investigated. Normal Wistar-kyoto (WKY) rats were used as negative control, and spontaneously hypertensive rats (SHR) were randomly assigned to receive pla- cebo or SMB. SMB (1 g/kg·d) was injected intraperitoneally for 12 weeks. Systolic blood pressure (SBP) and left ventricular mass index (LVMI) were measured. HE, VG and immunohistochemical staining combined with computed morphometry were employed to evaluate the cardiomyocyte size, diameter, the collagen volume fraction (CVF), perivascular circumferential area (PVCA), and tumor necrosis factor-α (TNF-α) expression in the left ventricular tissue. The results showed, as compared with WKY rats, the SBP, LVMI, cardiomyocyte size, diameter, CVF, PCVA, and TNF-α expression were increased markedly in the 20-week-old spontaneously hypertensive rats. SMB decreased LVMI (P0.05). It was suggested that chronic administration of SMB could inhibit and reverse the development of LVH in spontaneously hypertensive rats independent of BP. TNF-α may be involved in the reversal mecha- nism of LVH by SMB.

关键词： salvia miltiorrhiza bge spontaneously hypertensive rats left ventricular hypertrophy tumor necrosis factor-α

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