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2018中国遗传学会第十次全国会员代表大会暨学术讨论会

作者： Rui Shu Shujuan Wu Mengwei Feng Ying Wang Qin Min Junshan Gao Yan Meng School of life sciences Anhui Agricultural University Institute of Sericulture Anhui Academy of Agricultural Sciences

Tetrahydrobiopterin（BH4） is an essential coenzyme of aromatic amino acid hydroxylases and nitric oxide synthase. BH4 deficiency is associated with numerous metabolic syndromes and neuropsychological disorders in human. Sepiapterin reductase（SPR） catalyzes the third step in the de novo BH4 synthesis pathway, which is similar between insects and mammals. Although we have cloned and identified several enzyme genes involving in salvage and regeneration pathways of BH4 synthesis, including carbonyl reductase（CR）, dihydrofolate reductase（DHFR）, pterin-4 a-carbinolamine dehydratase（PCD） and dihydropteridine reductase（DHPR） from the silkworm Bombyx mori, knowledge about the molecular regulation mechanism of alternative BH4 synthesis network is very limited. Our previous studies showed that the expression of Bm Dhpr was activated in the brain and sexual glands while BmPcd was expressed in a wider special pattern when the de novo pathway of BH4 was lacked in lemon, a spontaneous BmSpr mutant silkworm. Recently, by using RNAi and transgenic tools, we found that the expression of Bm Dhfr was significantly up-regulated in both BmN cells and silkworm larvae when BmSpr expression was knocked down. These results indicate that BmDHFR might play an important role through the salvage pathway in BH4 synthesis and metabolism system of B. mori. This report gives new information for better understanding biological function of the alternative BH4 synthesis network in B. mori.

关键词： BH4 deficient Bombyx mori salvage pathway SPR,DHFR

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Improved Growth and Stress Tolerance in the Arabidopsis oxtl Mutant Triggered by Altered Adenine Metabolism

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Molecular Plant 2012年第6期5卷 1310-1332页

作者： Suchada Sukrong Kil-Young Yun Patrizia Stadler Charan Kumar Tony Facciuolo Barbara A.Moffatt Deane L.Falconec Department of Plant and Soil Science University of KentuckyLexingtonKY 40546USA Present address:Department of Pharmacognosy Faculty of Pharmaceutical SciencesChulalongkorn UniversityBangkokThailand Department of Biological Sciences University of MassachusettsOne University AvenueLowellMA 01854USA Present address:Fungi and Plant Co.Ltd Chungcheongbuk-doRepublic of Korea Department of Biology University of WaterlooWaterlooOntarioCanada

Plants perceive and respond to environmental stresses with complex mechanisms that are often associ- ated with the activation of antioxidant defenses. A genetic screen aimed at isolating oxidative stress-tolerant lines of Arabidopsis thaliana has identified oxtl, a line that exhibits improved tolerance to oxidative stress and elevated temperature but displays no apparent deleterious growth effects under non-stress conditions. Oxtl harbors a muta- tion that arises from the altered expression of a gene encoding adenine phosphoribosyltransferase （APT1）, an enzyme that converts adenine to adenosine monophosphate （AMP）, indicating a link between purine metabolism, whole-plant growth responses, and stress acclimation. The oxtl mutation results in decreased APT1 expression that leads to reduced enzymatic activity. Correspondingly, oxtl plants possess elevated levels of adenine. Decreased APT enzyme activity dir- ectly correlates with stress resistance in transgenic lines that ectopically express APT1. The metabolic alteration in oxtl plants also alters the expression of several antioxidant defense genes and the response of these genes to oxidative chal- lenge. Finally, it is shown that manipulation of adenine levels can induce stress tolerance to wild-type plants. Collectively, these results show that alterations in cellular adenine levels can trigger stress tolerance and improve growth, leading to increases in plant biomass. The results also suggest that adenine might play a part in the signals that modulate responses to abiotic stress and plant growth.

关键词： abiotic/oxidative environmental stress acclimation priming purine signaling salvage pathway thermotolerance.

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