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Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year involving 60 patients

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Neural Regeneration Research 2022年第8期17卷 1809-1813页

作者： Jia-Ni Li Chen-Chen Xie Chang-Qing Li Gui-Fang Zhang Hao Tang Chuan-Na Jin Jing-Xi Ma Lan Wen Ke-Ming Zhang Ling-Chuan Niu Department of Neurology The Second Affiliated Hospital of Chongqing Medical UniversityChongqingChina Department of Neurology Chongqing General HospitalUniversity of Chinese Academy of SciencesChongqingChina Chongqing Key Laboratory of Neurodegenerative Diseases ChongqingChina Department of Neurology West China Hospital of Sichuan UniversityChengduSichuan ProvinceChina Clinical College Chongqing Medical and Pharmaceutical CollegeChongqingChina

Transcutaneous auricular vagus nerve stimulation(ta-VNS)is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral auricular branch of the vagus *** have been recent reports that ta-VNS combined with conventional rehabilitation training promotes the recovery of neurological function of patients with acute ***,these were small-sample-sized studies on the recovery of neurological function in patients after percutaneous vagus nerve stimulation in the subacute and chronic phases after *** double-blinded randomized controlled trial involved 60 acute ischemic or hemorrhagic stroke patients aged 18-80 years who received treatment in the Second Affiliated Hospital of Chongqing Medical *** subjects were randomly assigned to receive ta-VNS or sham ta-VNS combined with conventional rehabilitation *** follow-up results over 1 year revealed that ta-VNS combined with conventional rehabilitation training greatly improved the recovery of motor and sensory functions and emotional responses compared with sham ta-VNS combined with conventional rehabilitation *** were no obvious side *** findings suggest that ta-VNS combined with conventional rehabilitation training for the treatment of acute ischemic or hemorrhagic stroke patients is safe and effective.

关键词： activity of daily living early stage treatment emotional disorder limb dysfunction neural regeneration randomized controlled clinical trial rehabilitation safety of treatment stroke transcutaneous auricular-vagus nerve stimulation

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