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safety assessment of a novel marine multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 according to phenotype and whole genome-sequencing analysis

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Food Science and Human Wellness 2024年第4期13卷 2048-2059页

作者： Xueyan Mo Mengcheng Zhou Yanmei Li Lili Yu Huashang Bai Peihong Shen Xing Zhou Haojun Zhu Huijie Sun Ru Bu Chengjian Jiang State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources Guangxi Research Center for Microbial and Enzyme Engineering TechnologyCollege of Life Science and TechnologyGuangxi UniversityNanning 530004China National Engineering Research Center for Non-Food Biorefinery State Key Laboratory of Non-Food Biomass and Enzyme TechnologyGuangxi Research Center for Biological Science and TechnologyGuangxi Academy of SciencesNanning 530007China Guangxi Key Laboratory for Green Processing of Sugar Resources College of Biological and Chemical EngineeringGuangxi University of Science and TechnologyLiuzhou 545006China

The application of microorganisms as probiotics is limited due to lack of safety evaluation.Here,a novel multi-stress-tolerant yeast Meyerozyma guilliermondii GXDK6 with aroma-producing properties was identified from marine mangrove microorganisms.Its safety and probiotic properties were assessed in accordance with phenotype and whole-genome sequencing analysis.Results showed that the genes and phenotypic expression of related virulence,antibiotic resistance and retroelement were rarely found.Hyphal morphogenesis genes(SIT4,HOG1,SPA2,ERK1,ICL1,CST20,HSP104,TPS1,and RHO1)and phospholipase secretion gene(VPS4)were annotated.True hyphae and phospholipase were absent.Only one retroelement(Tad1-65_BG)was found.Major biogenic amines(BAs)encoding genes were absent,except for spermidine synthase(JA9_002594),spermine synthase(JA9_004690),and tyrosine decarboxylase(inx).The production of single BAs and total BAs was far below the food-defined thresholds.GXDK6 had no resistance to common antifungal drugs.Virulence enzymes,such as gelatinase,DNase,hemolytic,lecithinase,and thrombin were absent.Acute toxicity test with mice demonstrated that GXDK6 is safe.GXDK6 has a good reproduction ability in the simulation gastrointestinal tract.GXDK6 also has a strong antioxidant ability,β-glucosidase,and inulinase activity.To sum up,GXDK6 is considered as a safe probiotic for human consumption and food fermentation.

关键词： Meyerozyma guilliermondii safety assessment Probiotics Marine mangrove microorganisms Whole-genome sequencing analysis

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Risk identification and safety assessment of human-computer interaction in integrated avionics based on STAMP

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Journal of Systems Engineering and Electronics 2024年第3期35卷 689-706页

作者： ZHAO Changxiao LI Hao ZHANG Wei DAI Jun DONG Lei School of safety Science and Engineering Civil Aviation University of ChinaTianjin 300300China Shenzhen Dajiang Innovation Technology Co. Ltd.Shenzhen 518057China Key Laboratory of Civil Aircraft Airworthiness Technology Civil Aviation Administration of ChinaTianjin 300300China

To solve the problem of risk identification and quantitative assessment for human-computer interaction(HCI)in complex avionics systems,an HCI safety analysis framework based on system-theoretical process analysis(STPA)and cognitive reliability and error analysis method(CREAM)is proposed.STPACREAM can identify unsafe control actions and find the causal path during the interaction of avionics systems and pilot with the help of formal verification tools automatically.The common performance conditions(CPC)of avionics systems in the aviation environment is established and a quantitative analysis of human failure is carried out.Taking the head-up display(HUD)system interaction process as an example,a case analysis is carried out,the layered safety control structure and formal model of the HUD interaction process are established.For the interactive behavior“Pilots approaching with HUD”,four unsafe control actions and35 causal scenarios are identified and the impact of common performance conditions at different levels on the pilot decision model are analyzed.The results show that HUD's HCI level gradually improves as the scores of CPC increase,and the quality of crew member cooperation and time sufficiency of the task is the key to its HCI.Through case analysis,it is shown that STPACREAM can quantitatively assess the hazards in HCI and identify the key factors that impact safety.

关键词： avionics human-computer interaction(HCI) safety assessment system-theoretic accident model and process human reliability analysis

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Analysis of safety assessment and Testing of Heavy Traffic Vehicles on Old Bridges Without Data

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Journal of World Architecture 2024年第1期8卷 35-39页

作者： Qing Yang Jiang Feng China Merchants Chongqing Highway Engineering Testing Center CO. LTD.Chongqing 400060China

This article presents a real-life project that aimed to evaluate the safety of traffic vehicles on old bridges without any prior data.The project involved various safety inspections,including conventional,static,and dynamic load inspections and safety assessments.After conducting these tests,it was concluded that the structure of the old bridge is relatively safe,with only a few bumps.The bridge could function normally following appropriate treatment.The analysis provides valuable insights into the assessment of the quality and safety of such bridges to ensure the safe driving of heavy vehicles.

关键词： Old bridge Absence of data Heavy vehicles safety inspection safety assessment

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safety assessment for buried drainage box culvert under influence of underground connected aisle blasting:A case study

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Frontiers of Structural and Civil Engineering 2023年第2期17卷 191-204页

作者： Wenchang SUN Nan JIANG Chuanbo ZHOU Jinshan SUN Tingyao WU Faculty of Engineering China University of GeosciencesWuhan 430074China Hubei(Wuhan)Institute of Explosion and Blasting Technology Jianghan UniversityWuhan 430056China

Blasting engineering in complex urban environments is considered to influence the safety and stability of the overlying drainage box culvert structure owing to vibration.Therefore,field blasting and vibration tests were performed on the blasting engineering of the Wuhan Metro Line 8 connected aisle,and the LS-DYNA software was used to analyze the dynamic response characteristics of an underground drainage box culvert during the blasting test.The vibration response evolution law of the buried drainage box culvert under blasting vibration was investigated,and a safe surface control standard for the blast vibration of a drainage box culvert is proposed.The results reveal that the maximum tensile stress of the box culvert structure was 0.33 MPa.The peak particle velocity(PPV)and peak tensile stress(PTS)of the drainage box culvert decreased as the water level in the box culvert increased.Based on the relationship between the tensile stress of the box culvert,PPV of the box culvert,and PPV of the surface,it is proposed that the surface control velocity of the buried drainage box culvert is 1.36 cm/s.

关键词： drainage box culvert underpass blasting dynamic response numerical simulation safety assessment

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safety assessment of monosodium glutamate based on intestinal function and flora in mice

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Food Science and Human Wellness 2022年第1期11卷 155-164页

作者： Jinzhao Xu Mengqi Tang Yini Liu Jinghan Xu Xiaoxi Xu Key Laboratory of Dairy Science Ministry of Education/College of Food ScienceNortheast Agricultural UniversityHarbin 150030China

Although monosodium glutamate(MSG)is a widely used food additive,its safety and systemic side effects have not been fully clarified.The intestinal flora is closely associated with human health;however,it remains unclear whether MSG consumption can affect health by acting on the intestinal flora.In this study,serum biomarkers,intestinal structure,intestinal immunity,and intestinal flora were examined to investigate the effects of different doses of sodium glutamate on the body,intestinal function,and intestinal flora of mice.The results showed that 30 mg/kg MSG had no significant effect on serum C-reactive protein,trimethylamine N-oxide,angiotensin II,intestinal interleukin(IL)-1β,IL-6,tumor necrosis factor-α,secretory IgA and fecal albumin in mice,but also promoted intestinal development and regulated the intestinal flora.Moreover,1500 mg/kg MSG increased the risk of cardiovascular disease and damaged the intestinal structure and flora.In this study,MSG was also found to be healthier than salt at the equivalent sodium concentration.Collectively,these findings suggested that low doses of MSG were safe for mice and may have some health benefits as a probiotic by promoting intestinal development and regulating the intestinal flora.

关键词： Monosodium glutamate safety assessment Intestinal flora Intestinal inflammation

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Handling Uncertainty in Human Cognitive Reliability Method for safety assessment Based on DSET

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Computer Modeling in Engineering & Sciences 2022年第7期132卷 201-214页

作者： Yujun Su Xianghao Gao Hong Qian Xiaoyan Su State Key Laboratory of Nuclear Power safety Monitoring Technology and Equipment Shenzhen518172China School of Automation Engineering Shanghai University of Electric PowerShanghai200090China

Human Reliability Analysis(HRA)is an important part in safety assessment of a large complex system.Human Cognitive Reliability(HCR)model is a method of evaluating the probability that operators fail to complete during diagnostic decision making within a limited time,which is widely used in HRA.In the application of this method,cognitive patterns of humans are required to be considered and classified,and this process often relies on the evaluation opinions of experts which is highly subjective and uncertain.How to effectively express and process this uncertain and subjective information plays a critical role in improving the accuracy and applicability of HCR.In this paper,a new model was proposed to deal with the uncertain information which exists in the processes of cognitive pattern classification in HCR.First,an evaluation panel was constructed based on expert opinions and processing including setting corresponding anchor points and qualitative indicators of different cognitive patterns,and mapping them to fuzzy numbers and unit intervals.Second,based on the evaluation panel,different analysts judge the cognitive pattern types of actual specific events and provide the level of confidence he or she has in the judgments.Finally,the evaluation opinions of multiple analysts were expressed and fused based on the Dempster-Shafer Evidence Theory(DSET),and the fused results were applied to the HCR model to obtain the Human Error Probability(HEP).A case study was used to demonstrate the procedure and effectiveness of the proposed method.

关键词： safety assessment human reliability analysis human cognitive reliability human error probability DempsterShafer evidence theory

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Demonstration of safety characteristics and effects on gut microbiota of Lactobacillus gasseri HMV18

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Food Science and Human Wellness 2024年第2期13卷 611-620页

作者： Xianxian Jia Miaomiao Jia Xiang Gao Xiang Li Mengyuan Wang Shengqiang Du Rui Huang Xiaotong Li Jun Zhang Shujin Li Chunling Ma Yan Zhang Bin Cong Department of Pathogen Biology Institute of basic MedicineHebei Medical UniversityShijiazhuang 050017China Research Unit of Digestive Tract Microecosystem Pharmacology and Toxicology Chinese Academy of Medical SciencesShijiazhuang 050017China Institute of Basic Medicine Hebei Medical UniversityShijiazhuang 050017China College of Forensic Medicine Hebei Key Laboratory of Forensic MedicineCollaborative Innovation Center of Forensic Medical Molecular IdentificationHebei Medical UniversityShijiazhuang 050017China Hebei Food safety Key Laboratory Hebei Food Inspection and Research InstituteShijiazhuang 050227China

Human normal flora is a source of probiotics.The safety characteristics of a specific isolate determine its application in foods or drugs.The food-borne-pathogen antagonist strain Lactobacillus gasseri HMV18 is one of the isolates from normal human flora.In this work,we assessed the in vitro pH tolerance,bile tolerance,biogenic amine production,mucin utilization,and safety of in vivo administration to mice to evaluate general health,organ-body weight index,organ histopathological change,whether L.gasseri HMV18 can colonize in the gut or modulate the gut microbiota after oral administration.The results suggest that L.gasseri HMV18 can tolerate pH 3 for 2 h,3%bile for 3 h,biogenic amine negative,mucin usage negative,does not encode verified toxins,and cause no visible change in mice's organs.L.gasseri HMV18 might not colonize in mice's gut,but can significantly affect the structure of gut microbiota.A bibliographical survey suggested that there were as few as 8 opportunistic infection cases from 1984 to 2022 and that the possibility for L.gasseri to cause infection is relatively low.Therefore,this work provides a basis for the foods or drugs application of L.gasseri HMV18 and gives a map of experiments for the safety assessment of probiotics.

关键词： Probiotics Lactobacillus gasseri safety assessment Gut microbiota

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safety assessment of condensed phosphate intake from fishery and processed marine food products in Korea with respect to gender,age,and region

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Food Quality and safety 2021年第2期5卷 161-169页

作者： Hyung Soo Kim Dae Yong Jang Ye Ji Koo Eun Chul Pack Seung Ha Lee Dal Woong Choi Health Science Research Center Korea UniversitySeoulRepublic of Korea department of Public Health Sciences Graduate SchoolKorea UniversitySeoulRepublic of Korea School of Health and Environmental Sciences Korea UniversitySeoulRepublic of Korea and department of Health and safety Convergence Science Graduate SchoolKorea UniversitySeoulRepublic of Korea.

Condensed phosphates are used as food additives,especially in marine products and meat,to improve food quality.The import and consumption of fishery and processed marine food products in Republic of Korea have reportedly increased by~5 per cent annually.However,processed marine food products are often intentionally adulterated with excessive amounts of condensed phosphates to increase their weight.Excessive intake of condensed phosphates via consuming processed marine food products can lead to various adverse effects on human health due to anionic imbalance.Herein,we conducted a safety assessment of condensed phosphates in 14 types of fishery and processed marine food products in Korea for the first time.Subgroup analysis of various factors including gender,age,and region was also performed,and the risk level of exposure for each group was estimated.safety assessments by age and gender indicated that infants were at the highest risk.In the regional safety assessment,Chungnam,the most inland region,showed the lowest risk.For both the general and the high-intake groups(95th percentile)in all classifications,the risk was lower(<20 per cent)than the international standard,and the phosphorus content of the 14 types of processed marine products in Korea was confirmed to be safe for human consumption.

关键词： Condensed phosphates safety assessment ion chromatography fishery and processed marine food products

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Overcharge-to-thermal-runaway behavior and safety assessment of commercial lithium-ion cells with different cathode materials:A comparison study

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Journal of Energy Chemistry 2021年第4期30卷 484-498页

作者： Zhenpo Wang Jing Yuan Xiaoqing Zhu Hsin Wang Lvwei Huang Yituo Wang Shiqi Xu National Engineering Laboratory for Electric Vehicles Beijing Institute of TechnologyBeijing 100081China Collaborative Innovation Center for Electric Vehicles in Beijing Beijing 100081China Materials Science and Technology Division Oak Ridge National LaboratoryOak Ridge 37831TNUSA Shanghai Jieneng Automotive Technology Co. Ltd.Shanghai 201804China State-assigned Electric Vehicle Power Battery Testing Center China North Vehicle Research InstituteBeijing 100072China

In this paper,overcharge behaviors and thermal runaway(TR)features of large format lithium-ion(Liion)cells with different cathode materials(LiFePO4(LFP),Li[Ni_(1/3)Co_(1/3)Mn_(1/3)]O_(2)(NCM111),Li[Ni_(0.6)Co_(0.2)Mn_(0.2)]O_(2)(NCM622)and Li[Ni_(0.8)Co_(0.1)Mn_(0.1)]O_(2)(NCM811))were investigated.The results showed that,under the same overcharge condition,the TR of LFP Li-ion cell occurred earlier compared with the NCM Li-ion cells,indicating its poor overcharge tolerance and high TR risk.However,when TR occurred,LFP Li-ion cell exhibited lower maximum temperature and mild TR response.All NCM Liion cells caught fire or exploded during TR,while the LFP Li-ion cell only released a large amount of smoke without fire.According to the overcharge behaviors and TR features,a safety assessment score system was proposed to evaluate the safety of the cells.In short,NCM Li-ion cells have better performance in energy density and overcharge tolerance(or low TR risk),while LFP Li-ion cell showed less severe response to overcharging(or less TR hazards).For NCM Li-ion cells,as the ratio of nickel in cathode material increases,the thermal stability of the cathode materials becomes poorer,and the TR hazards increase.Such a comparison study on large format Li-ion cells with different cathode materials can provide deeper insights into the overcharge behaviors and TR features,and provide guidance for engineers to reasonably choose battery materials in automotive applications.

关键词： Lithium-ion battery Cathode materials Overcharge Thermal runaway Overcharge tolerance safety assessment

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A New safety assessment Method Based on Belief Rule Base With Attribute Reliability

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IEEE/CAA Journal of Automatica Sinica 2021年第11期8卷 1774-1785页

作者： Zhichao Feng Wei He Zhijie Zhou Xiaojun Ban Changhua Hu Xiaoxia Han Rocket Force University of Engineering Xi’an 710025China Harbin Normal University Harbin 150080China Harbin Institute of Technology Harbin 150001China

safety assessment is one of important aspects in health management.In safety assessment for practical systems,three problems exist:lack of observation information,high system complexity and environment interference.Belief rule base with attribute reliability(BRB-r)is an expert system that provides a useful way for dealing with these three problems.In BRB-r,once the input information is unreliable,the reliability of belief rule is influenced,which further influences the accuracy of its output belief degree.On the other hand,when many system characteristics exist,the belief rule combination will explode in BRB-r,and the BRB-r based safety assessment model becomes too complicated to be applied.Thus,in this paper,to balance the complexity and accuracy of the safety assessment model,a new safety assessment model based on BRB-r with considering belief rule reliability is developed for the first time.In the developed model,a new calculation method of the belief rule reliability is proposed with considering both attribute reliability and global ignorance.Moreover,to reduce the influence of uncertainty of expert knowledge,an optimization model for the developed safety assessment model is constructed.A case study of safety assessment of liquefied natural gas(LNG)storage tank is conducted to illustrate the effectiveness of the new developed model.

关键词： Belief rule base(BRB) belief rule reduction reliability safety assessment structure adjustment

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