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Soluble Interleukin 2 receptor-Alpha (sil-2rα) in the Peripheral Blood of Dogs—Comparison of Malignant Neoplasia with Other Diseases

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Open Journal of Veterinary Medicine 2013年第2期3卷 176-183页

作者： Christian Prachar Franz-Josef Kaup Stephan Neumann Small Animal Clinic Institute of Veterinary Medicine University of Goettingen Goettingen Germany

Background: Cytokines are mediators of diseases. Expression levels in the blood could be of clinical relevance. Objective: sil-2rα is used as a marker for different malignancies in human medicine. The aim of this study was to show if sil-2rα is detectable and if there is any correlation to different diseases in dogs. Methods: For this purposes sil-2rα concentrations in the blood were measured in healthy dogs, in dogs with different non-neoplastic diseases and benign tumors and in dogs with malignant tumors. Serum levels of sil-2rα were measured by using a human specific enzyme linked immunosorbent assay (ELISA). results: Measurement of sil-2rα was successful in most of the samples. Dogs with diseases have significantly increased serum levels of sil-2rα compared to healthy controls. sil-2rα serum levels are higher in patients with non-neoplastic diseases and benign tumors than in those with malignant neoplasia. There is a strong correlation between sil-2rα and leukocyte count. Conclusion: Measurements of sil-2rα in serum may be helpful in detecting stages and grades of inflammation in the progression of disease. sil-2rα could actually not be used as an indicator for malignant diseases in dogs like in humans. The strong correlation between sil-2rα and the leukocyte count indicates the inflammatory response to the disease. This could be helpful in giving a prognosis in some cases, because the inflammatory reaction is of prognostic relevance in different diseases including malignant and non-malignant neoplasia. Although the results of our research studies were very promising, further studies should be performed with a canine ELISA.

关键词： sil-2rα Soluble Interleukin-2 receptor Alpha ELISA Dog

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巨细胞包涵体病患儿血清sil—2rα水平的研究

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中国实验临床免疫学杂志 1995年第3期7卷 27-28页

作者：王晓菌张惠沈阳中国医科大学第二临床学院儿科110003

本文应用双抗体夹心ＥＬＩＳＡ法检测了２８例巨细胞包涵体病患儿血清ＳＩＬ－２Ｒα水平，并与正常同龄儿做了对照研究，结果为：巨细胞包涵体病患儿血清ＳＩＬ－２Ｒα水平明显高于正常同龄儿，提示巨细胞包涵体病患儿存在免疫功能紊... 详细信息

本文应用双抗体夹心ＥＬＩＳＡ法检测了２８例巨细胞包涵体病患儿血清ＳＩＬ－２Ｒα水平，并与正常同龄儿做了对照研究，结果为：巨细胞包涵体病患儿血清ＳＩＬ－２Ｒα水平明显高于正常同龄儿，提示巨细胞包涵体病患儿存在免疫功能紊乱，故应在治疗方面注意调节。

关键词：巨细胞包涵体病血清 sil-2rα 儿童

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CA-125,sil-2rα联检对筛查卵巢癌的临床意义

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放射免疫学杂志 2001年第6期14卷 573-573页

作者：高文陈宝萍吕秀菱江苏省扬州市第一人民医院中心实验室 225001 东南大学医学院附属扬州医院妇产科

卵巢癌死亡率居于妇科肿瘤之首,在女性所患肿瘤中占第五位,如能早期诊断可显著提高生存率和生存质量.目前超声检查及一些肿瘤标志物检测由于其敏感性和特异性不高,未能起到筛查作用.我们调查了120名妇科疾病患者,包括良性疾病和卵巢癌病... 详细信息

卵巢癌死亡率居于妇科肿瘤之首,在女性所患肿瘤中占第五位,如能早期诊断可显著提高生存率和生存质量.目前超声检查及一些肿瘤标志物检测由于其敏感性和特异性不高,未能起到筛查作用.我们调查了120名妇科疾病患者,包括良性疾病和卵巢癌病人,检测其血清中CA-125,sil-2rα,以其达到筛查卵巢癌的目的.材料和方法一、临床资料:1998年1月～2000年10月间50名良性妇科疾病患者(如囊肿、腺瘤、纤维瘤等).30名Ⅰ～Ⅱ期卵巢癌患者,40名Ⅲ～Ⅳ期卵巢癌病人,以上对象年龄为30～60岁,且皆经临床和病理证实.二、方法:血清标本皆取自手术前,空腹.分离血清后贮-30℃备检,统计学方法为t检验和q检验.CA-125 IrMA kit由北京北方生物技术研究所提供.sil-2rα ELISA kit由美国ADI&ALEXIS公司提供,按说明书操作.CA-125参考正常值＜35U/ml,sil-2rα参考正常值＜670U/ml.

关键词： CA-125 sil-2rα 筛查卵巢癌

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Soluble IL-2rα correlates with imbalances of Th1/Th2 and Tc1/Tc2 cells in patients with acute brucellosis

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Infectious Diseases of Poverty 2020年第4期9卷 170-170页

作者： Hua-Li Sun Cheng-Jie Ma Xiu-Fang Du Si-Yuan Yang Xiao Lv Hong Zhao Ling-Hang Wang Yun-Xia Tang Xing-Wang Li rong-Meng Jiang Department of Infectious Diseases The Affiliated Hospital of Qingdao UniversityQingdaoShandongChina The Laboratory of Infectious Diseases Centre Beijing Di Tan HospitalCapital Medical UniversityBeijingChina Department of Infectious Diseases the Third People HospitalLinfen CityShanxi ProvinceChina Department of Laboratory Medicine the Third People HospitalLinfen CityShanxi ProvinceChina Center for Infectious Diseases Beijing Di Tan HospitalCapital Medical UniversityBeijingChina

Background Previous studies showed that soluble IL-2rαis an important marker of cellular immune activation and might be a marker of treatment efficacy for children with ***,data regarding adult patients with brucellosis were *** aim of study was to explore the potential role of serum sil-2rαevaluating treatment responses in adult patients with brucellosis,and T cell immune status was also *** During January 2016–April 2017,30 patients with acute brucellosis from the Third People’s Hospital of Linfen in Shanxi Province and Beijing Di Tan Hospital,and 28 healthy controls were included in this *** blood samples were collected before and after six weeks of antibiotic *** sil-2rαlevels were measured by enzyme-linked immunosorbent assay,and the percentage of Th1,Th2,Tc1,Tc2,and Tregs was detected by flow cytometry after intracellular staining for cytokines(interferon-γand interleukin-4)and Foxp3 in T lymphocytes from peripheral *** obtained data were analyzed with Wilcoxon ranked sum tests for paired values,Mann-Whitney U-tests for comparisons between patients and healthy controls,and Spearman rank tests for correlation *** Serum sil-2rαlevels were significantly higher in patients than in controls(P=0.001).A significant decline was observed in patients after the cessation of treatment(Preturn to normal(P>0.05).Th1,Tc1,Th2,and Tc2 cell frequencies were higher in patients than in healthy subjects(P2 and Tc1/Tc2 ratios were significantly lower(P=0.0305 and 0.0005,respectively)and returned to normal levels after *** patients with acute brucellosis,serum sil-2rαlevels were negatively correlated with the Th1/Th2 ratio(r=−0.478,P=0.028),Tc1/Tc2 ratio(r=−0.677,P=0.001),and Tc1 percentage(r=−0.516,P=0.017).Serum sil-2rαand Tc2 percentages were positively correlated(r=0.442,P=0.045).Conclusions Based on the correlations with Th1/Th2 and Tc1/Tc2 ratios,serum sI

关键词： Brucellosis sil-2rα Tc1 Tc2 Th1 Th2

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