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Hepatitis B surface antigen seroconversion after HBV reactivation in non-Hodgkin's lymphoma

World Journal of Gastroenterology 2014年第17期20卷 5165-5170页

作者： Wei-Ping Liu Wen Zheng Yu-Qin song Ling-Yan Ping Gui-Qiang Wang Jun Zhu Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Department of LymphomaPeking University Cancer Hospital and Institute Department of Infectious Diseases Center for Liver DiseasesPeking University First Hospital

Reactivation of hepatitis B virus(HBV)can occur in lymphoma patients infected with HBV when they receive chemotherapy or *** administration of lamivudine(LAM)reduces the morbidity and mortality associated with HBV ***,what defines HBV reactivation and the optimal duration of treatment with LAM have not yet been clearly *** reactivation may occur due to the cessation of prophylactic LAM,although re-treatment with nucleoside analogs may sometimes result in hepatitis B surface antigen(HBsAg)seroconversion,which is a satisfactory endpoint for the management of HBV *** report a case of HBV reactivation in a 68-year-old HBsAg-positive patient who received rituximab-based immunochemotherapy for follicular *** reactivation developed following cessation of prophylactic LAM *** patient subsequently received treatment with entecavir(ETV),which led to a rapid and sustained suppression of HBV replication and HBsAg *** also appraised the literature concerning HBV reactivation and the role of ETV in the management of HBV reactivation in lymphoma patients.A total of 28 cases of HBV reactivation have been reported as having been treated with ETV during or after immunosuppressive chemotherapy in lymphoma *** conclude that ETV is an efficacious and safe treatment for HBV reactivation following LAM cessation in lymphoma patients treated with rituximab-based immunochemotherapy.

关键词： Hepatitis B surface antigen, seroconversion, Non-Hodgkin’ s lymphoma, rituximab, entecavir

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