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An Investigation of the Effects of B7-H4 Gene rs10754339 and miR-125a Gene rs12976445 on Cancer Susceptibility

生物医学与环境科学:英文版 2023年第9期36卷 814-825页

作者： JIN Yu Chen DONG Li Juan YANG Qin Yue XIONG Wei Ning WANG Wei Yi FENG Xian Hong YU Wei HUANG Wei CHEN Bi Feng Department of Biological Science and Technology School of ChemistryChemical Engineering and Life SciencesWuhan University of TechnologyWuhan 430081HubeiChina Department of Biotechnology Institute of WUTAMUWuhan University of TechnologyWuhan 430081HubeiChina Department of Clinical Laboratory Wuhan Xinzhou District People's HospitalWuhan 430400HubeiChina Department of Air Crew Service School of Civil AviationWuhan Business and Trade Vocational CollegeWuhan 430062HubeiChina

Objective To investigate the effects of the B7-H4 gene rs10754339 and miR-125a gene rs12976445 on cancer susceptibility through a case-control study and meta-analysis.Methods A total of 1,490 cancer patients(lung/gastric/liver/:550/460/480)and 800 controls were recruited in this case-control study.The meta-analysis was performed by pooling the data from previous related studies and the present study.Results The results of this study showed that in the Hubei Han Chinese population,the rs10754339gene was significantly associated with the risk of lung and gastric cancer but not liver cancer,and the rs12976445 gene was significantly associated with the risk of lung cancer but not liver or gastric cancer.The meta-analysis results indicated that rs10754339 and rs12976445 contributed to cancer susceptibility in the Chinese population and also revealed a significant association between rs10754339and breast cancer risk,as well as between rs12976445 and lung cancer risk.Conclusion The B7-H4 gene rs10754339 and miR-125a gene rs12976445 may be the potential genetic markers for cancer susceptibility in the Chinese population,which should be validated in future studies with larger sample sizes in other ethnic populations.

关键词： B7-H4 gene miR-125a gene rs10754339 rs12976445 Cancer susceptibility

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