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Anticancer Activities of Plant Secondary Metabolites:rice callus suspension culture as a New Paradigm

rice science 2021年第1期28卷 13-30页

作者： Wusirika Ramakrishna Anuradha Kumari Nafeesa Rahman Pallavi Mandave Department of Biochemistry Central University of PunjabBathindaPunjab 151001India Department of Biological Sciences Michigan Technological University1400 Townsend Drive HoughtonMichigan 49931USA Interactive Research School for Health Affairs Bharati VidyapeethPuneMaharashtra 411043India

Plant natural products including alkaloids,polyphenols,terpenoids and flavonoids have been reported to exert anticancer activity by targeting various metabolic *** biological pathways regulated by plant products can serve as novel drug *** natural compounds or their derivatives used for cancer treatment and some novel plant-based compounds which are used in clinical trials were *** suspension culture with secondary metabolites can provide a continuous source of plant pharmaceuticals without time and space *** research has shown that rice callus suspension culture can kill>95%cancer cells with no significant effect on the growth of normal *** role of candidate genes and metabolites which are likely to be involved in the process and their potential to serve as anticancer and anti-inflammatory agents were *** scale production of plant callus suspension culture and its constituents can be achieved using elicitors which enhance specific secondary metabolites combined with bioprocess technology.

关键词： plant metabolite cancer metabolism rice callus suspension culture cytotoxicity anticancer agent

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Anticancer Activity of rice callus suspension cultures from Aromatic Varieties and Metabolites Regulated in Treated Cancer Cell Lines

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rice science 2024年第4期31卷 449-462,I0027-I0030页

作者： Anuradha KUMARI Wusirika RAMAKRISHNA Department of Biochemistry Central University of PunjabPunjab 151401India

Tissue culture techniques were used to produce large amounts of bioactive compounds with medicinal potential, overcoming space and time constraints for cancer prevention. rice callus suspension cultures(RCSC) and seed extracts prepared from aromatic rice varieties were used to evaluate the cytotoxic impact on human colon and lung cancer cell lines, as well as a normal control cell line, using Taxol as a positive control. RCSC and seed extracts from two Indian aromatic rice varieties were applied at different concentrations to treat the cancer cell lines and normal lung fibroblasts over varying time intervals. Apoptosis was assessed in 1:5 dilutions of the A549 and HT-29 cell lines treated with RCSC for 72 h, using propidium iodide staining and flow cytometry. RCSC showed a more potent cytotoxic effect than seed extracts with minimal effect on the normal cell line, in contrast to Taxol. Confocal microscopy and flow cytometry further confirmed the apoptotic effect of RCSC. Gas chromatography-mass spectrometry-based metabolic profiling identified metabolites involved in cytotoxicity and highlighted altered pathways. RCSC is proposed as an alternative source for the development of novel anticancer drugs with reduced side effects.

关键词： anticancer cytotoxicity metabolite profiling plant tissue culture rice callus suspension culture secondary metabolite

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