检索结果-南通市图书馆

Dysbiosis of gut microbiome affecting small intestine morphology and immune balance:a rhesus macaque model

Zoological Research 2020年第1期41卷 20-31页

作者： Hong-Zhe Li Nan Li Jing-Jing Wang Heng Li Xing Huang Lei Guo Hui-Wen Zheng Zhan-Long He Yuan Zhao Ze-Ning Yang Hai-Tao Fan Man-Man Chu Jin-Xi Yang Qiong-Wen Wu Long-Ding Liu Institute of Medical Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeKunmingYunnan 650118China Key Laboratory of Systemic Innovative Research on Virus Vaccine Chinese Academy of Medical SciencesKunmingYunnan 650118China

There is a growing appreciation for the specific health benefits conferred by commensal microbiota on their hosts.Clinical microbiota analysis and animal studies in germ-free or antibiotic-treated mice have been crucial for improving our understanding of the role of the microbiome on the host mucosal surface;however,studies on the mechanisms involved in microbiome-host interactions remain limited to small animal models.Here,we demonstrated that rhesus monkeys under short-term broad-spectrum antibiotic treatment could be used as a model to study the gut mucosal host-microbiome niche and immune balance with steady health status.Results showed that the diversity and community structure of the gut commensal bacteria in rhesus monkeys were both disrupted after antibiotic treatment.Furthermore,the 16S rDNA amplicon sequencing results indicated that Escherichia-Shigella were predominant in stool samples 9 d of treatment,and the abundances of bacterial functional genes and predicted KEGG pathways were significantly changed.In addition to inducing aberrant morphology of small intestinal villi,the depletion of gut commensal bacteria led to increased proportions of CD3+T,CD4+T,and CD16+NK cells in peripheral blood mononuclear cells(PBMCs),but decreased numbers of Treg and CD20+B cells.The transcriptome of PBMCs from antibiotic-treated monkeys showed that the immune balance was affected by modulation of the expression of many functional genes,including IL-13,VCAM1,and LGR4.

关键词： Gut microbiome rhesus macaque Antibiotic treatment Immune response Pathological changes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Single-nucleus transcriptomic profiling of multiple organs in a rhesus macaque model of SARS-CoV-2 infection

引用

Zoological Research 2022年第6期43卷 1041-1062页

作者： Qiang Ma Wenji Ma Tian-Zhang Song Zhaobo Wu Zeyuan Liu Zhenxiang Hu Jian-Bao Han Ling Xu Bo Zeng Bosong Wang Yinuo Sun Dan-Dan Yu Qian Wu Yong-Gang Yao Yong-Tang Zheng Xiaoqun Wang State Key Laboratory of Brain and Cognitive Science Institute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common DiseasesKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650223China Kunming National High-Level Biosafety Research Center for Non-Human Primates Center for Biosafety Mega-ScienceKunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China National Resource Center for Non-Human Primates National Research Facility for Phenotypic&Genetic Analysis of Model Animals(Primate Facility)Kunming Institute of ZoologyChinese Academy of SciencesKunmingYunnan 650107China LivzonBio Inc.ZhuhaiGuangdong 519045China State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China IDG/McGovern Institute for Brain Research Beijing Normal UniversityBeijing 100875China Advanced Innovation Center for Human Brain Protection Beijing Institute for Brain DisordersCapital Medical UniversityBeijing 100069China

Infection with severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) causes diverse clinical manifestations and tissue injuries in multiple organs.However, cellular and molecular understanding of SARS-CoV-2 infection-associated pathology and immune defense features in different organs remains incomplete. Here, we profiled approximately 77 000single-nucleus transcriptomes of the lung, liver,kidney, and cerebral cortex in rhesus macaques(Macaca mulatta) infected with SARS-CoV-2 and healthy controls. Integrated analysis of the multiorgan dataset suggested that the liver harbored the strongest global transcriptional alterations. We observed prominent impairment in lung epithelial cells, especially in AT2 and ciliated cells, and evident signs of fibrosis in fibroblasts. These lung injury characteristics are similar to those reported in patients with coronavirus disease 2019(COVID-19).Furthermore, we found suppressed MHC class I/II molecular activity in the lung, inflammatory response in the liver, and activation of the kynurenine pathway,which induced the development of an immunosuppressive microenvironment. Analysis of the kidney dataset highlighted tropism of tubule cells to SARS-CoV-2, and we found membranous nephropathy(an autoimmune disease) caused by podocyte dysregulation. In addition, we identified the pathological states of astrocytes and oligodendrocytes in the cerebral cortex, providing molecular insights into COVID-19-related neurological implications. Overall, our multi-organ single-nucleus transcriptomic survey of SARS-CoV-2-infected rhesus macaques broadens our understanding of disease features and antiviral immune defects caused by SARS-CoV-2 infection,which may facilitate the development of therapeutic interventions for COVID-19.

关键词： SARS-CoV-2 rhesus macaque Animal model Single-nucleus RNA sequencing Antiviral immune defects Multiple organs

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Differential Transcriptomic Landscapes of SARS-CoV-2 Variants in Multiple Organs from Infected rhesus macaques

引用

Genomics, Proteomics & Bioinformatics 2023年第5期21卷 1014-1029页

作者： Tingfu Du Chunchun Gao Shuaiyao Lu Qianlan Liu Yun Yang Wenhai Yu Wenjie Li Yong Qiao Sun Cong Tang Junbin Wang Jiahong Gao Yong Zhang Fangyu Luo Ying Yang Yun-Gui Yang Xiaozhong Peng National Kunming High-level Biosafety Primate Research Center Institute of Medical BiologyChinese Academy of Medical Sciences and Peking Union Medical CollegeKunming 650118China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China CAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentCollege of Future TechnologyBeijing Institute of GenomicsChinese Academy of Sciences and China National Center for BioinformationBeijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 100049China Institute of Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)caused the persistent coronavirus disease 2019(COVID-19)pandemic,which has resulted in millions of deaths worldwide and brought an enormous public health and global economic burden.The recurring global wave of infections has been exacerbated by growing variants of SARS-CoV-2.In this study,the virological characteristics of the original SARS-CoV-2 strain and its variants of concern(VOCs;including Alpha,Beta,and Delta)in vitro,as well as differential transcriptomic landscapes in multiple organs(lung,right ventricle,blood,cerebral cortex,and cerebellum)from the infected rhesus macaques,were elucidated.The original strain of SARS-CoV-2 caused a stronger innate immune response in host cells,and its VOCs markedly increased the levels of subgenomic RNAs,such as N,Orf9b,Orf6,and Orf7ab,which are known as the innate immune antagonists and the inhibitors of antiviral factors.Intriguingly,the original SARS-CoV-2 strain and Alpha variant induced larger alteration of RNA abundance in tissues of rhesus monkeys than Beta and Delta variants did.Moreover,a hyperinflammatory state and active immune response were shown in the right ventricles of rhesus monkeys by the up-regulation of inflammation-and immune-related RNAs.Furthermore,peripheral blood may mediate signaling transmission among tissues to coordinate the molecular changes in the infected individuals.Collectively,these data provide insights into the pathogenesis of COVID-19 at the early stage of infection by the original SARS-CoV-2 strain and its VOCs.

关键词： SARS-CoV-2 Variant of concern Subgenomic RNA rhesus macaque Transcriptome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

引用

Protein & Cell 2022年第12期13卷 920-939页

作者： Chun-Chun Gao Man Li Wei Deng Chun-Hui Ma Yu-Sheng Chen Yong-Qiao Sun Tingfu Du Qian-Lan Liu Wen-Jie Li Bing Zhang Lihong Sun Si-Meng Liu Fengli Li Feifei Qi Yajin Qu Xinyang Ge Jiangning Liu Peng Wang Yamei Niu Zhiyong Liang Yong-Liang Zhao Bo Huang Xiao-Zhong Peng Ying Yang Chuan Qin Wei-Min Tong Yun-Gui Yang CAS Key Laboratory of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentCollege of Future TechnologyBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China China National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijing 100000China Department of Pathology Institute of Basic Medical SciencesMolecular Pathology Research CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China NHC Key Laboratory of Human Disease Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China Institute of Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunming 650031China Center for Experimental Animal Research Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Pathology Peking Union Medical College HospitalMolecular Pathology Research CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Immunology&National Key Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Clinical Immunology Center Chinese Academy of Medical SciencesBeijing 100005China Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China State Key Laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Med

SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries,how-ever,the underlying mechanism,in particular immune responses in different organs,remains elusive.In this study,comprehensive transcriptomic alterations of 14 tissues from rhesus macaque infected with SARS-CoV-2 were analyzed.Compared to normal controls,SARS-CoV-2 infection resulted in dysregulation of genes involving diverse functions in various examined tissues/organs,with drastic transcriptomic changes in cerebral cortex and right ventricle.Intriguingly,cerebral cortex exhibited a hyperinflammatory state evidenced by sig-nificant upregulation of inflammation response-related genes.Meanwhile,expressions of coagulation,angio-genesis and fibrosis factors were also up-regulated in cerebral cortex.Based on our findings,neuropilin 1(NRP1),a receptor of SARS-CoV-2,was significantly elevated in cerebral cortex post infection,accompanied by active immune response releasing inflammatory factors and signal transmission among tissues,which enhanced infection of the central nervous system(CNS)in a positive feedback way,leading to viral encephalitis.Overall,our study depicts a multi-tissue/organ tran-scriptomic landscapes of rhesus macaque with early infection of SARS-CoV-2,and provides important insights into the mechanistic basis for COVID-19-asso-ciated clinical complications.

关键词： SARS-CoV-2 NRP1 inflammation central nervous system viral encephalitis rhesus macaque

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Pathogenic analysis of coxsackievirus A10 in rhesus macaques

引用

Virologica Sinica 2022年第4期37卷 610-618页

作者： Suqin Duan Fengmei Yang Yanyan Li Yuan Zhao Li Shi Meng Qin Quan Liu Weihua Jin Junbin Wang Lixiong Chen Wei Zhang Yongjie Li Ying Zhang Jingjing Zhang Shaohui Ma Zhanlong He Qihan Li Institute of Medical Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeYunnan Key Laboratory of Vaccine Research Development on Severe Infectious DiseaseKunming650118China Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Life Science and Technology Beijing University of Chemical TechnologyBeijing100029China

Coxsackievirus A10(CV-A10)is one of the etiological agents associated with hand,foot and mouth disease(HFMD)and also causes a variety of illnesses in humans,including pneumonia,and myocarditis.Different people,particularly young children,may have different immunological responses to infection.Current CV-A10 infection animal models provide only a rudimentary understanding of the pathogenesis and effects of this virus.The characteristics of CV-A10 infection,replication,and shedding in humans remain unknown.In this study,rhesus macaques were infected by CV-A10 via respiratory or digestive route to mimic the HFMD in humans.The clinical symptoms,viral shedding,inflammatory response and pathologic changes were investigated in acute infection(1–11 day post infection)and recovery period(12–180 day post infection).All infected rhesus macaques during acute infection showed obvious viremia and clinical symptoms which were comparable to those observed in humans.Substantial inflammatory pathological damages were observed in multi-organs,including the lung,heart,liver,and kidney.During the acute period,all rhesus macaques displayed clinical signs,viral shedding,normalization of serum cytokines,and increased serum neutralizing antibodies,whereas inflammatory factors caused some animals to develop severe hyperglycemia during the recovery period.In addition,there were no significant differences between respiratory and digestive tract infected animals.Overall,all data presented suggest that the rhesus macaques provide the first non-human primate animal model for investigating CV-A10 pathophysiology and assessing the development of potential human therapies.

关键词： Coxsackievirus A10(CV-A10) Hand Foot and mouth disease(HFMD) Non-human primate model rhesus macaque Pathogenic analysis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

3D anatomy of autonomic innervations in immune organs of a non-human primate and the human

引用

Fundamental Research 2023年第2期3卷 249-256页

作者： Ying Cao Tingting Liu Xin Zhou Wei Fu Jiali Li Jing Yang State Key Laboratory of Membrane Biology School of Life SciencesCenter for Life SciencesPeking UniversityBeijing 100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Department of General Surgery Peking University Third HospitalBeijing 100191China IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Kunming Institute of Zoology Chinese Academy of SciencesKunmingYunnan 650223China Shenzhen Bay Laboratory Institute of Molecular PhysiologyShenzhenGuangdong 518055China Chinese Institute for Brain Research Beijing 102206China

Direct neural inputs to immune organs have been observed for decades,with their functions in neuroimmune regulation being increasingly appreciated.However,the current knowledge of such neural structures,particularly those in primate immune organs,remains incomplete.In this study,we comprehensively assessed the 3D anatomy of autonomic(i.e.,sympathetic and parasympathetic)innervations in the immune organs of the rhesus macaque monkey and the human for the first time.Aided with the advanced technique of whole-tissue immunolabeling and lightsheet fluorescence imaging,we revealed the densely organized sympathetic architecture in the parenchyma of the adult monkey and human spleens.On the other hand,only sparse,if any,sympathetic inputs were observed inside the lymph nodes,Peyer's patches,or thymus.In contrast,there were minimal parasympathetic innervations in the parenchyma of these examined immune organs.Together,this work has documented the unique patterns of autonomic innervations in different immune organs of a non-human primate and the human,serving as an essential reference for future research on neuroimmune regulation in the field.

关键词： 3D neural anatomy Autonomic innervations Immune organs rhesus macaque Human

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of social and climatic factors on birth sex ratio in Macaca mulatta in Mount Taihangshan area

引用

Integrative Zoology 2015年第2期10卷 199-206页

作者： Jundong TIAN Baishi WANG Zhenlong WANG Jindong LIU Jiqi LU Institute of Biodiversity and Ecology Zhengzhou UniversityZhengzhouChina Jiyuan Administration of Taihangshan macaque National Nature Reserve JiyuanChina Department of Wildlife Diseases Leibniz Institute for Zoo and Wildlife ResearchBerlinGermany

Sex allocation theory predicts the optimal investment to male and female offspring.However,a biased sex ratio requires explanations as to why the deviation occurs.rhesus macaque(Macaca mulatta)is the most widely distributed nonhuman primate species and the Taihangshan macaque(Macaca mulatta tcheliensis)occupies the northern limit of all rhesus macaque natural populations worldwide.We observed one macaque troop(Wangwu-1[WW-1])inhabiting Taihangshan macaque National Nature Reserve and recorded all birth events and the sex of newborn macaques from 2004 to 2013.Our aim was to apply the Trivers–Willard hypothesis to this free-ranging rhesus macaque troop,and to understand the relationship between climatic parameters(precipitation and temperature)and birth sex ratio.We found that the total newborn macaques showed a female-biased sex ratio at birth in the WW-1 troop,but there were no significant biased birth sex ratios in all matriarchs and in high-ranking and middle-ranking matrilineal units.However,the low-ranking macaque matrilineal unit was significantly female-biased.Moreover,we found that the annual precipitation of the previous year was positively associated with the birth sex ratio,and there was an interactive effect of troop size and current winter temperature on the birth sex ratio.The underlying mechanisms for the effects of social and climatic factors on birth sex ratio could be complex,and we discuss several plausible explanations.

关键词： birth sex ratio precipitation rhesus macaque social rank Trivers-Willard hypothesis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

How does the motor relearning program improve neurological function of brain ischemia monkeys?

引用

Neural Regeneration Research 2013年第16期8卷 1445-1454页

作者： Yong Yin Zhen Gu Lei Pan Lu Gan Dongdong Qin Bo Yang Jin Guo Xintian Hu Tinghua Wang Zhongtang Feng Department of Rehabilitation Medicine Fourth Hospital of Kunming Medical University Department of Neurosurgery Fourth Hospital of Kunming Medical University Kunming Institute of Zoology Chinese Academy of Sciences Department of Nuclear Medicine Fourth Hospital of Kunming Medical University Department of Pathology Fourth Hospital of Kunming Medical University Institute of Neuroscience Kunming Medical University

The motor relearning program can significantly improve various functional disturbance induced by ischemic cerebrovascular diseases. However, its mechanism of action remains poorly understood. In injured brain tissues, glial fibrillary acidic protein and neurofilament protein changes can reflect the condition of injured neurons and astrocytes, while vascular endothelial growth factor and basic fibroblast growth factor changes can indicate angiogenesis. In the present study, we induced ischemic brain injury in the rhesus macaque by electrocoagulation of the M1 segment of the right middle cerebral artery. The motor relearning program was conducted for 60 days from the third day after model establishment. Immunohistochemistry and single-photon emission CT showed that the numbers of glial fibrillary acidic protein-, neurofilament protein-, vascular endothelial growth factor- and basic fibroblast growth factor-positive cells were significantly increased in the infarcted side compared with the contralateral hemisphere following the motor relearning program. Moreover, cerebral blood flow in the infarcted side was significantly improved. The clinical rating scale for stroke was used to assess neurological function changes in the rhesus macaque following the motor relearning program. Results showed that motor function was improved, and problems with consciousness, self-care ability and balance function were significantly ameliorated. These findings indicate that the motor relearning program significantly promoted neuronal regeneration, repair and angiogenesis in the surroundings of the infarcted hemisphere, and improve neurological function in the rhesus macaque following brain ischemia.

关键词： neural regeneration brain injury stroke motor relearning program rhesus macaque brainischemia animal model neurological function neurotrophic factor single-photon emission CT cerebral blood flow grants-supported paper neuroregeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Parameter comparison of white matter diffusion tensor imaging （DTI） in rhesus macaques （Macaca mulatta）

引用

Zoological Research 2014年第3期35卷 182-185页

作者： Yin MO Fang CHAO Ming SONG Ci-Rong LIU Hui-Lang LIU Xi-Ying QIAN Xu-Dong ZHAO Department of Medical Imaging the First Affiliated Hospital of Kunming Medical University Kunming 650032 China National Laboratory of Pattern Recognition Institute of A utomation Chinese Academy of Sciences Beijing 1 O0190 China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan province Kunming Institute of Zoology Chinese Academy of Sciences Kunming 650223 China Department of Neurology the First Yunnan Provincial Hospital Kunming 650032 China Laboratory of Primate Neuroscience Institute of Biophysics Chinese Academy of Sciences Beo'ing 100101 China

In this study, we analyzed diffusion tensor imaging （DTI） results of brain white matter in rhesus macaques （Macaca mulatta） with four different parameter settings and found that the sequence A （b=1000 s/mm^2, spatial resolution=1.25 mm ×1.25 mm× 1.25 mm, numbers of direction=33, NSA=3） and B （b=800 s/mm^2, spatial resolution= 1.25 mm× 1.25 mm× 1.25 mm, numbers of direction=33, NSA=3） could accurately track coarse fibers. The fractional anisotropy （FA） derived from sequence C （b=1000s/mm^2, spatial resolution=0.55 mm×0.55 mm×2.5 mm, direction number=33, NSA=3） was too fuzzy to be used in tracking white matter fibers. By comparison, the high resolution and the FA with high contrast of gray matter and white matter derived from sequence D （b=800 s/mm^2, spatial resolution=1.0 mm×1.0 mm ×1.0 mm, numbers of direction=33, NSA=3） qualified in its application in tracking both thick and thin fibers, making it an optimal DTI setting for rhesus macaques.

关键词： DTI Whiter matter rhesus macaque

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Disease Progression Patterns of SHIV-KB9 in rhesus macaques of Chinese Origin in Comparison with Indian macaques

引用

Biomedical and Environmental Sciences 2008年第4期21卷 302-307页

作者： QIANG LIU GUI-BO YANG HUI ZHAO QIANG WEI HUI XING CHUAN QIN YI-MING SHAO State Key Laboratory for Infectious Diseases Prevention and Control National Center for AIDS/STD Control and Prevention Chinese Center for Disease Control and Prevention Beijing 100050 China Institute of Laboratory Animal Science Chinese Academy of Medical Sciences （CAMS） and Peking Union Medical College （PUMC） Beijing 100021 China

Objective To develop a model of SHIV-KB9/Chinese origin rhesus （Ch Rh） macaques for vaccine research and to compare the pathogenesis of SHIV-KB9 in Ch Rh macaques with that reported in Indian rhesus （Ind Rh） macaques. Methods Seven mamu-A＊01 negative Ch Rh macaques were inoculated intravenously with 1-10000 MID50 of SHIV-KB9. The monkeys were monitored for viral load, CD4, CDS, SHIV-specific antibody and virus genetic variation. The results were compared with those previously observed in Ind Rh macaques. Results As compared to that observed in Ind Rh macaques, SHIV-KB9 in Ch Rh macaques displayed three identical disease progression patterns. However, the primary pattern was not identical between the two subspecies. The level of plasma viremia differed in SHIV-KB9-infected Ch Rh macaques which exhibited different outcomes from those in Ind Rh macaques. Generally, the values of viral load and the maintenance of CD4^＋ T cells were associated with humoral responses. Otherwise, the viral genetic distances （divergence, diversity） were larger in animals （M419, M425） with their CD4^＋ T cells profoundly depleted. Conclusion The model of SHIV-KB9/Ch Rh macaques displays a relatively slow progression to AIDS compared with Ind Rh macaques, which may more accurately reflect the potential of candidate vaccines in humans.

关键词： SHIV-KB9 rhesus macaque Subspecies Viral load CD4/CD8 ratio Antibody titer Gene variation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：