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Membrane fusion reverse micelle platforms as potential oral nanocarriers for efficient internalization of free hydrophilic peptides

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Nano Research 2023年第7期16卷 9768-9780页

作者： Mengting Lin Linjie Wu Yiying Lu Xiaoyan Bao Haiqing Zhong Qi Dai Qiyao Yang Yiyi Xia Xin Tan Yaxin Qin Ruolin Jiang Min Han Institute of Pharmaceutics College of Pharmaceutical SciencesZhejiang UniversityHangzhou 310058China Department of Pharmacy Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310058China Hangzhou Institute of Innovative Medicine Zhejiang UniversityHangzhou 310058China The Second Affiliated Hospital College of MedicineZhejiang UniversityHangzhou 310058China

Orally administered peptides or proteins are garnering increasing preference owing to their superiority in terms of patient compliance and ***,the development of oral protein formulations has stalled due to the low bioavailability of macromolecules that encounter the aggressive gastrointestinal environment and harsh mucus villi ***,we propose an ideal reverse micelle/self-emulsifying drug delivery system(RM/SEDDS)nanoplatform that is capable of improving the oral bioavailability of hydrophilic peptides by preventing enzymatic degradation and enhancing mucosal *** the passage through the mucus,the self-emulsifying drug delivery system with optimal surface properties effectively penetrates the viscoelastic mucosal barrier,followed by the exposure of the inner reverse micelle amphipathic vectors,which autonomously form continua with the lipidic cell membrane and facilitate the internalization of *** membrane-fusion mechanism inaugurates a new way for hydrophilic peptide delivery in the free form,circumventing the traditional impediments of the cellular internalization of nanocarriers and subsequent poor release of *** more importantly,reverse micelles are not spatially specific to the laden drugs,which enables their delivery for a myriad of peptide clinical *** conclusion,as an exquisitely designed nanoplatform,RM/SEDDS overcomes multiple physiological barriers and opens a new path for drug cellular entry,providing new prospects for the development of oral drug delivery systems.

关键词： oral drug delivery system reverse micelle self-emulsifying drug delivery system membrane fusion hydrophilic peptide

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Effect of Dissolved CO_2 on Protein Solubilization in reverse micelle

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Chinese Chemical Letters 1999年第4期10卷 331-332页

作者： Hai Fei ZHANG Bu Xing HAN Jie LU Guan Ying YANG Hai Ke YAN(Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080) Institute of Chemistry Chinese Academy of Sciences Beijing 100080 China

Effect of dissolved CO2 on bovine serum albumin (BSA) solubilization in the reverse micelles of sodium bis (2-ethylhexyl) sulfosuccinate (AOT) in 2,2,4-trimethylpentane (iso-octane) has been studied at 308.2 K. It was found that BSA can be precipitated completely by CO2 while the AOT and water remain in the iso-octane continuous phase. This opens up a possibility for recovery of pure protein solids directly from reverse micellar solutions.

关键词： Compressed CO_2 protein precipitation reverse micelle

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Synthesis of Crystalline Nanosized Titanium Dioxide via a reverse micelle Method at Room Temperature

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Chinese Chemical Letters 2003年第1期14卷 100-103页

作者： Dong Bai ZHANG Li Min QI Hu Min CHENG Ji Ming MA College of Chemistry and Molecular Engineering Peking UniversityBeijing 100871

Crystalline TiO2 nanoparticles were synthesized by hydrolysis of titanium tetrabutoxide in the presence of hydrochloric acid in NP-5 (Igepal CO-520)/ cyclohexane reverse micelle solution at room temperature. Pure rutile nanoparticles were obtained at an appropriate acid concentration. The influences of various reaction conditions such as the concentration of acids, water content value (w=[H2O]/[NP-5]) on the formation, crystal phase, morphology, and size of the TiO2 particles were investigated.

关键词： reverse micelle nanoparticle titanium dioxide.

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Terahertz spectroscopy of water in nonionic reverse micelles

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Chinese Optics Letters 2024年第1期22卷 128-134页

作者：张佳琦闫玉岳刘立媛张伟力 Centre for Terahertz Waves and College of Precision Instrument and Optoeletronics Engineering Tianjin UniversityTianjin 300072China School of Electrical and Computer Engineering Oklahoma State UniversityStillwaterOklahoma 74078United States

The dynamics of water within a nanopool of a reverse micelle is heavily affected by the amphiphilic *** this work,the terahertz(THz)spectra of cyclohexane/Igepal/water nonionic reverse micelle mixture are measured by THz timedomain spectroscopy and analyzed with two Debye models and complex permittivity of background with volume *** on the fitted parameters of bulk and fast water,the molar concentration of all kinds of water molecules and hydration water molecule number per Igepal molecule are *** find that slow hydration water has the highest proportion in water when the radius parameterω_(0)<10,while bulk water becomes the main component whenω_(0)≥*** feature radius ratio of nonhydrated and hydrated water to total water nanopool is roughly obtained from 0.39 to 0.85 with increasingω_(0).

关键词： reverse micelle water dynamics THz spectroscopy

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Supramolecular micelles and reverse micelles Based on Cyclodextrin Polyrotaxanes

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Chinese Journal of Chemistry 2014年第1期32卷 73-77页

作者： Qiao Jin Gongyan Liu Jian Ji[*] MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China Email: Jian Ji (jijian@***)[*]MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China Tel.: 0086-0571-87953729 Fax: 0086-0571-87953729

A new supramolecular self-assembly approach to construct micelles and reverse micelles was ***-hydrophilic block copolymers poly(ethylene oxide)-b-poly(N-isopropylacrylamide) (PEO-b-PNIPAAm) was synthesized via atom transfer radical polymerization (ATRP) using PEO *** of the lower critical solution temperature (LCST) phase behavior of PNIPAAm,PEO-b-PNIPAAm block copolymers self-assembled to form PNIPAAm-core micelles at 40 ℃.The PNIPAAm-core micelles were disassembled to unimers when the temperature was decreased to 25 ℃.But the addition of α-cyclodextrins (α-CDs) could induce the formation of PNIPAAm-shell micelles because of the 'channel-type' crystallities induced by PEO/α-CDs *** assembly and disassembly procedure of micelles and reverse micelles were investigated by dynamic light scattering (DLS),X-ray diffraction (XRD),1H NMR and transmission electron microscopy (TEM).

关键词： cyclodextrin polyrotaxane reverse micelle supramolecular

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Fluorescence quenching of eosin upon adsorption by colloidal silver mediated in aqueous solution and reverse micelles

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Chinese Journal of Chemistry 1996年第4期14卷 315-320页

作者： Zang, L Shen, T CHINESE ACAD SCI INST PHOTOG CHEMBEIJING 100101PEOPLES R CHINA

The optical effects of the adsorption of eosin on the colloidal sliver particle have been investigated in aqueous solutions. It was found that upon adsorption the fluorescence of eosin was effectively quenched. This was explained as the photoinduced interfacial electron transfer from the excited singlet state of eosin to the silver particle. Decreasing pH of the solution favors the adsorption of eosin and so enhances the fluorescence quenching. For comparison, the fluorescence quenching in reverse micelles was also investigated. The quenching behavior was much different from that mediated in aqueous solution. This was attributed to the unique microenvironment of reverse micelles.

关键词： photoinduced electron transfer eosin reverse micelle

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Kinetic Studies on of Veratryl the Lignin Peroxidase Catalyzed Oxidation Alcohol by H2O2 in AOT/Isooctane/ Toluene/Water reverse micelles

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Chinese Journal of Chemistry 2007年第11期25卷 1627-1631页

作者：刘金庭黄锡荣高培基 Key Laboratory for Colloid and Interface Chemistry of Ministry of Education Shandong University Jinan Shandong 250100 China State Key Laboratory of Microbial Technology of China Shandong University Jinan Shandong 250100 China

The steady state kinetics of the lignin peroxidase （LIP） catalyzed oxidation of veratryl alcohol （VA） by H2O2 in a sodium bis（2-ethylhexyl） sulfosuccinate （AOT）/isooctane/toluene/water reverse micellar medium was studied and a comparison with the corresponding aqueous medium was made to understand the effect of the reverse micellar medium on the catalytic mechanism and kinetic parameters. Results indicated that the model reaction in the AOT reverse micelle followed the ping-pong mechanism with true kcat, Km,VA and KmH2O2 being 59.6min^-1, 13.9 mmol· L^-1 and 94.8 μmol·L^-1, respectively; inhibition of high level of H2O2 on LiP followed the reversible competitive pattern with Ki being 0.140 mmol·L^-1. The reaction mechanism and inhibition pattern in the AOT reverse micellar medium were the same as those in bulk aqueous medium, but the kinetic parameters except KmH2O2 were greatly different in the two media. The kcat and Ki values in the reverse micelle were approximately 2 and 20 times smaller than the corresponding values in the aqueous solution, but the Michaelis constant of VA was approximately 100 times greater than that in the aqueous solution. The above mentioned differences in the kinetic parameters were caused by the microheterogeneity and the interface of the AOT reverse micelle, which resulted in the partitioning of VA and H2O2, and by the changes of the conformation of LiP and the reactivity of the substrates.

关键词： lignin peroxidase veratryl alcohol reverse micelle kinetic parameter

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Formation of reverse micelles in supercritical carbon dioxide and its thermodynamics

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Frontiers of Chemical Science and Engineering 2007年第3期1卷 283-286页

作者： WEN Zhen DANG Zhi ZONG Minhua ZHU Zhixin School of Chemistry and Chemical Engineering Shenzhen UniversityShenzhen 518060China Postdoctoral Station of Light Industry Technology and Engineering South China University of TechnologyGuangzhou 510640China School of Environmental Science and Engineering South China University of TechnologyGuangzhou 510640China

The solubilization behavior of methyl orange as a solvation probe in multiple systems composed of super-critical carbon dioxide,surfactants and co-solvents,is *** is concluded that some surfactants,such as sodium bis-(2-ethylhexyl)sulfosuccinate(AOT)and isooctyl phenol polyethoxylate(TX-10),could form reverse micelles in supercritical carbon dioxide under the action of *** formation of reverse micelles is a spontaneous process *** for the nonionic surfactant TX-10,the formation of reverse micelles is dependent on the entropy increase in the system,while for the anionic sur-factant AOT,the micellization is mainly dominated by the increase in enthalpy at higher temperatures,but by the increase in entropy at lower temperatures.

关键词： supercritical carbon dioxide reverse micelle surfactant probe thermodynamics

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Size Changes of reverse micelles after Extraction of Peanut Protein and Their Forward Extraction Rates

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Grain & Oil Science and Technology 2018年第1期1卷 32-39页

作者： WANG Limin LIU Kunlun CHEN Fusheng YIN Lijun College of Food Science and Technology Henan University of Technology

The aim of this study was to detect the size changes of reverse micelles after extraction of peanut protein and their forward extraction rates. Factors that affect the size of reverse micelles and the extraction of peanut protein were also investigated. The size of reverse micelles and the size changes were measured according to the theory of dynamic light scattering under different conditions such as different sodium bis(2-ethylhexyl) sulfosuccinate(AOT) concentrations, p H values, ion concentrations, and salt *** the increase of AOT surfactant concentrations in a certain range, the size of empty and full reverse micelles increased and the forward extraction rate decreased. The effect of pH on empty reverse micelles was not significant. However, the effect of pH on the full reverse micelle size and forward extraction rate were significant. Its forward extraction rate increased to the maximum39.6% at pH 7.5. The increase of the salt concentration of a buffer solution in a certain range decreased the size of empty and full reverse micelles and reduced the forward extraction rate of peanut protein. Ionic species had important effects on reverse micelles and peanut protein extraction. An increase in the amount of buffer solution enlarged the empty reverse micelle size in 0.03%-0.11%(V/V). However, it did not translate to a larger reverse micelle size. The size of the empty reverse micelles containing K_2SO_2 reached 24.1 nm with a 0.19%(V/V) buffer solution added. The sizes of the full reverse micelles were larger than those of the empty reverse micelles after forward extraction. However, maximum sizes were achieved with the addition of a 0.03%(V/V) buffer solution. The amount of 0.03%(V/V) buffer solution added was appropriate for extracting peanut protein.

关键词： reverse micelle Size Forward extraction Peanut protein

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Phase separation in solvent extraction of cobalt from acidic sulfate solution using synergistic mixture containing dinonylnaphthalene sulfonic acid and 2-ethylhexyl 4-pyridinecarboxylate ester

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Transactions of Nonferrous Metals Society of China 2019年第5期29卷 1107-1116页

作者： Ting HUANG Yong-xi WANG Hui-ping HU Fang HU Yu-qing LUO Shi-jun LIU College of Chemistry and Chemical Engineering Central South UniversityChangsha 410083China

Phase separation rate is a critical character in determining the usefulness of a solvent extraction system in hydrometallurgy. A survey of the synergistic mixture containing dinonylnaphthalene sulfonic acid (HDNNS) and 2-ethylhexly 4-pyridinecarboxylate ester (4PC) for the extraction of cobalt from acidic single metal sulfate solution was carried out to suggest how the physicochemical properties and the morphology of the reverse micelles in the loaded organic phase affect the phase separation. The results show that effective parameters affecting the phase separation are the viscosity and the excess water uptake of the loaded organic phase. It is obvious that the specific settling rate (SSR) decreases with the apparent increase of these two parameters. The measurement of small angle X-ray scattering (SAXS) proves that the morphology of the reversed micelles in the loaded organic phase changes evidently with the change of the specific settling rate (SSR).

关键词： synergistic solvent extraction phase separation specific settling rate reverse micelle cobalt

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