检索结果-南通市图书馆

Neuroprotective effects of exogenous brain-derived neurotrophic factor on amyloid-beta 1-40-induced retinal degeneration

引用

Neural Regeneration Research 2023年第2期18卷 382-388页

作者： Mohd Aizuddin Mohd Lazaldin Igor Iezhitsa Renu Agarwal Puneet Agarwal Nafeeza Mohd Ismail Department of Biosciences Faculty of ScienceUniversiti Teknologi MalaysiaJohor BahruMalaysia School of Medicine International Medical UniversityKuala LumpurMalaysia Department of Pharmacology and Bioinformatics Volgograd State Medical UniversityVolgogradRussia Faculty of Medicine Universiti Teknologi MARASungai Buloh CampusSelangorMalaysia

Amyloid-beta(Aβ)-related alterations,similar to those found in the brains of patients with Alzheimer's disease,have been observed in the retina of patients with *** levels of brain-derived neurotrophic factor(BDNF)are believed to be associated with the neurotoxic effects of Aβ*** investigate the mechanism underlying the neuroprotective effects of BDNF on Aβ_(1-40)-induced retinal injury in Sprague-Dawley rats,we treated rats by intravitreal administration of phosphate-buffered saline(control),Aβ_(1-40)(5 nM),or Aβ_(1-40)(5 nM)combined with BDNF(1μg/mL).We found that intravitreal administration of Aβ_(1-40)induced retinal ganglion cell ***-Gold staining showed a significantly lower number of retinal ganglion cells in the Aβ_(1-40)group than in the control and BDNF *** the Aβ_(1-40)group,low number of RGCs was associated with increased caspase-3 expression and reduced TrkB and ERK1/2 *** abolished Aβ_(1-40)-induced increase in the expression of caspase-3 at the gene and protein levels in the retina and upregulated TrkB and ERK1/2 *** findings suggest that treatment with BDNF prevents RGC apoptosis induced by Aβ_(1-40)by activating the BDNF-TrkB signaling pathway in rats.

关键词： amyloid-beta 1-40 brain-derived neurotrophic factor Fluoro-Gold neuroprotection retinal ganglion cells(RGC) retinal toxicity tropomyosin receptor kinase B(TrkB)

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Safety of intravitreal quinupristin/dalfopristin in an animal model

引用

International Journal of Ophthalmology(English edition) 2016年第3期9卷 373-378页

作者： Veronica E.Giordano Sergio E.Hernandez-Da Mota Tania N.A dabache-Guel Armando Castillejos-Cheve Sonia Corredor-Casas Samantha M.Salinas-Longoria Rafael Romero-Vera Juan M.Jimenez-Sierra Jose L.Guerrero-Naranjo Virgilio Morales-Canton Department of Ophthalmology Retina and Vitreous Service Asociacion para Evitar la Ceguera en Mexico Vicente Garcia Torres 46 Coyoacan Barrio San Lucas Mexico City 04030 Mexico Ophthalmology Service Clinica David Boulevard Garcia de Leon 598 Nueva Chapultepec Morelia Michoacan 58280Mexico Department of Ophthalmology Glaucoma Service Asociacion para Evitar la Ceguera en Mexico Vicente Garcia Torres 46 Coyoacan Barrio San Lucas Mexico City 04030 Mexico Department of Ophthalmology Pathology Service Asociacion para Evitar la Ceguera en Mexico Vicente Garcia Tortes 46 Coyoacan Barrio San Lucas Mexico City 04030 Mexico

AIM： To determine whether different intravitreal doses of quinupristin/dalfopristin lead to electroretinographic or histological changes in the rabbit retina over one month period after injection. METHODS： Eighteen New Zealand white rabbits were divided into three treatment groups （groups 1 to 3） and different intravitreal doses of quinupristin/dalfopristin were tested in each group. The right eye was injected with the drug and the left eye received intravitreal injection of 5% dextrose water and served as control eye. The doses delivered to each group were 0.1 mg/0.1 mL, 1 mg/0.1 mL and 10 mg/0.1 mL. Simultaneous, bilateral, dark-adapted electroretinography and clinical images of both eyes were obtained in all groups before injection （baseline） and after 7, 14, 21 and 28d, followed by enucleation for histological examination. RESULTS： Subjects in the group 1 showed no signs of toxicity in the electroretinogram when compared with groups 2 and 3 （Kruskall-Wallis test, P=0.000）. By day 7, no electrical response to light stimuli was recorded in the treated eyes in groups 2 and 3, consistent with severe damage due to retinal toxicity. Light microscopy revealedno significant histopathological changes in the group 1, while rabbits in groups 2 and 3 had signs of granulomatous inflammation in most cases. CONCLUSION： Intravitreal 0.1 mg/0.1 mL doses of quinupristin/dalfopristin do not lead to electroretinographic or histological signs of retinal toxicity compared with 1 mg/0.1 mL and 10 mg/O.1 mL in this rabbit model.

关键词： endophthalmitis quinupristin/dalfopristin retinal toxicity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Suprachoroidal injection of ketorolac tromethamine does not cause retinal damage

引用

Neural Regeneration Research 2012年第35期7卷 2770-2777页

作者： Sumeng Liu Wu Liu Yaling Ma Kegao Liu Meizi Wang General Hospital of Ningxia Medical University Beijing Tongren Eye Center Beijing Tongren Hospital Capital Medical University Beijing Ophthalmology & Visual Sciences Key Lab

Rabbit right eyes were injected with 3 or 6 mg ketorolac tromethamine into the suprachoroidal space. Electroretinography results demonstrated no abnormal changes in rod cell response, maximum rod cell or cone cell mixing reaction, oscillation potential, cone cell response, waveform, amplitude, and potential of 30 Hz scintillation response in right eyes before injection, and at 1,2, and 4 weeks after injection. There was no difference between left （control） and right eyes. Under light microscopy, the histomorphology of cells in each retinal layer was normal at 4 weeks following 6 mg ketorolac tromethamine administration. These results indicate that a single suprachoroidal injection of 3 or 6 mg ketorolac tromethamine into rabbits was safe. Suprachoroidal space injection appears to be safe.

关键词： nonsteroidal anti-inflammatory drug ketorolac tromethamine segment disease retina suprachoroidal space retinal toxicity electroretinography pharmacology regeneration neuralregeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：