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The inter-visit variability of retinal blood flow velocity measurements using retinal function imager (RFI)

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Eye and Vision 2018年第1期5卷 275-282页

作者： Yuqing Deng Meng Li Gengyuan Wang Hong Jiang Jianhua Wang Jing Zhong Saiqun Li Jin Yuan State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CentreSun Yat-sen UniversityXianlie Road 54Guangzhou 510060China Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiamiFLUSA

Background:To determine the inter-visit variability of retinal blood flow velocities(BFVs)using a retinal function imager(RFI)in healthy young ***:Twenty eyes of 20 healthy young subjects were *** imaging was performed to obtain the BFVs in retinal arterioles and venules in a field measuring 7.3×7.3 mm^(2)(setting:35 degrees)centered on the fovea,and repeated measurements were obtained on two separate *** inter-visit variability of BFVs was assessed by the concordance correlation coefficient(CCC)and coefficient of variance(CV).Results:At the first visit,the mean BFV was 3.6±0.8 mm/s and 3.0±0.7 mm/s in arterioles and venules,respectively,which were not significantly different from those at the second visit(the BFV of arterioles was 3.5±0.8 mm/s,and the BFV of venules was 3.0±0.7 mm/s,P>0.05,respectively).The CCC was 0.72 in the BFVs of arterioles and 0.67 in venules,and the CV was 10.8%in the BFVs of arterioles and 11.0%in ***:The inter-visit variability using the retinal function imager(RFI)with a large field of view appeared to be good and comparable to previously reported intra-visit and inter-eye variability.

关键词： Inter-visit variability retinal blood flow velocity retinal function imager Concordance correlation coefficient(CCC) Coefficient of variance(CV)

Microvascular blood flow velocities measured with a retinal function imager: inter-eye correlations in healthy controls and an exploration in multiple sclerosis

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Eye and Vision 2018年第1期5卷 260-268页

作者： Liang Wang Ohemaa Kwakyi James Nguyen Esther Ogbuokiri Olwen Murphy Natalia Gonzalez Caldito Laura Balcer Elliot Frohman Teresa Frohman Peter A.Calabresi Shiv Saidha Department of Neurology Johns Hopkins University School of MedicineBaltimoreMDUSA Departments of Neurology Population Health and OphthalmologyNew York University School of MedicineNew YorkNYUSA Departments of Neurology and Ophthalmology University of Texas Austin Dell Medical SchoolAustinTXUSA

Background:The retinal microcirculation has been studied in various diseases including multiple sclerosis(MS).However,inter-eye correlations and potential differences of the retinal blood flow velocity(BFV)remain largely unstudied but may be important in guiding eye selection as well as the design and interpretation of studies assessing or utilizing retinal *** primary aim of this study was to determine inter-eye correlations in BFVs in healthy controls(HCs).Since prior studies raise the possibility of reduced BFV in MS eyes,a secondary aim was to compare retinal BFVs between MS eyes,grouped based on optic neuritis(ON)history and HC ***:Macular arteriole and venule BFVs were determined using a retinal function imager(RFI)in both eyes of 20 *** eye from a total of 38 MS patients comprising 13 eyes with ON(MSON)and 25 eyes without ON(MSNON)history were similarly imaged with ***:OD(right)and OS(left)BFVs were not significantly different in arterioles(OD:3.95±0.59 mm/s;OS:4.08±0.60 mm/s,P=0.10)or venules(OD:3.11±0.46 mm/s;OS:3.23±0.52 mm/s,P=0.06)in *** strong inter-eye correlations were also found between arteriolar(r=0.84,P<0.001)and venular(r=0.87,P<0.001)BFVs in ***(3.48±0.88 mm/s)and venular(2.75±0.53 mm/s)BFVs in MSNON eyes were significantly lower than in HC eyes(P=0.009 and P=0.005,respectively).Similarly,arteriolar(3.59±0.69 mm/s)and venular(2.80±0.45 mm/s)BFVs in MSON eyes were also significantly lower than in HC eyes(P=0.046 and P=0.048,respectively).Arteriolar and venular BFVs in MSON and MSNON eyes did not differ from each other(P=0.42 and P=0.48,respectively).Conclusions:Inter-eye arteriolar and venular BFVs do not differ significantly in HCs and are strongly *** findings support prior observations that arteriolar and venular BFVs may be reduced in MS ***,this seems to be the case in both MS eyes with and without a history of ON,raising the possibility of global blood flow alterations in ***

关键词： Inter-eye correlation Blood flow velocity retinal function imager Neurology Multiple sclerosis Optic neuropathy

Exploratory study of non-invasive,high-resolution functional macular imaging in subjects with diabetic retinopathy

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International Journal of Ophthalmology(English edition) 2021年第1期14卷 57-63页

作者： Thalmon R.Campagnoli Gábor Márk Somfai Jing Tian Delia Cabrera DeBuc William E.Smiddy Bascom Palmer Eye Institute Miller School of MedicineUniversity of MiamiMiamiFL 33136USA Department of Ophthalmology Semmelweis UniversityFaculty of MedicineBudapestHungary

AIM:To evaluate a high-resolution functional imaging device that yields quantitative data regarding macular blood flow and capillary network features in eyes with diabetic retinopathy(DR).METHODS:Prospective,cross-sectional comparative case-series in which blood flow velocities(BFVs)and noninvasive capillary perfusion maps(nCPMs)in macular vessels were measured in patients with DR and in healthy controls using the retinal functional imager(RFI)***:A total of 27 eyes of 21 subjects were studied[9 eyes nonproliferative diabetic retinopathy(NPDR),9 eyes proliferative diabetic retinopathy(PDR)and 9 controls].All diabetic patients were type *** patients with NPDR and 5 eyes with PDR also had diabetic macular edema(DME).The NPDR group included eyes with severe(n=3)and moderate NPDR(n=6),and were symptomatic.A significant decrease in venular BFVs was observed in the macular region of PDR eyes when compared to controls(2.61±0.6 mm/s and 2.92±0.72 mm/s in PDR and controls,respectively,P=0.019)as well as PDR eyes with DME compared to NPDR eyes(2.36±0.51 mm/s and 2.94±1.09 mm/s in PDR with DME and NPDR,respectively,P=0.01).CONCLUSION:The RFI,a non-invasive imaging tool,provides high-resolution functional imaging of the retinal microvasculature and quantitative measurement of BFVs in visually impaired DR *** isolated diminish venular BFVs in PDR eyes compared to healthy eyes and PDR eyes with DME in comparison to NPDR eyes may indicate the possibility of more retinal vein compromise than suspected in advanced DR.

关键词： macular blood flow capillary perfusion map non-invasive vascular imaging high-resolution imaging diabetic retinopathy retinal function imager

retinal tissue hypoperfusion in patients with clinical Alzheimer’s disease

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Eye and Vision 2018年第1期5卷 196-203页

作者： Giovana Rosa Gameiro Hong Jiang Yi Liu Yuqing Deng Xiaoyan Sun Bernardo Nascentes Bernard Baumel Tatjana Rundek Jianhua Wang Department of Ophthalmology Bascom Palmer Eye InstituteUniversity of Miami Miller School of Medicine1638 NW 10th AvenueMcKnight Building-Room 202AMiamiFL 33136USA Evelyn F.McKnight Brain Institute Department of NeurologyUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Ophthalmology Third Affiliated Hospital of Nanjing University of Chinese MedicineNanjingChina State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhouGuangdongChina School of Nursing and Health Studies University of MiamiMiamiFLUSA

Background:It remains unknow whether retinal tissue perfusion occurs in patients with Alzheimer’s *** goal was to determine retinal tissue perfusion in patients with clinical Alzheimer’s disease(CAD).Methods:Twenty-four CAD patients and 19 cognitively normal(CN)age-matched controls were recruited.A retinal function imager(RFI,Optical Imaging Ltd.,Rehovot,Israel)was used to measure the retinal blood flow supplying the macular area of a diameter of 2.5 mm centered on the *** flow volumes of arterioles(entering the macular region)and venules(exiting the macular region)of the supplied area were *** blood flow was calculated as the average of arteriolar and venular flow *** ultra-high-resolution optical coherence tomography(UHR–OCT)was used to calculate macular tissue *** segmentation software(Orion,Voxeleron LLC,Pleasanton,CA)was used to segment six intra-retinal layers in the 2.5 mm(diameter)area centered on the *** inner retina(containing vessel network),including retinal nerve fiber layer(RNFL),ganglion cell-inner plexiform layer(GCIPL),inner nuclear layer(INL)and outer plexiform layer(OPL),was segmented and tissue volume was *** was calculated as the flow divided by the tissue ***:The tissue perfusion in CAD patients was 2.58±0.79 nl/s/mm^(3)(mean±standard deviation)and was significantly lower than in CN subjects(3.62±0.44 nl/s/mm^(3),Pretinal layers between CAD and CN ***:This study is the first to show decreased retinal tissue perfusion that may be indicative of diminished tissue metabolic activity in patients with clinical Alzheimer’s disease.

关键词： Clinical Alzheimer’s disease retinal tissue perfusion Blood flow retinal tissue volume Hypoperfusion retinal function imager Optical coherence tomography

The effect of sildenafil on retinal blood velocity in healthy subjects

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Eye and Vision 2018年第1期5卷 269-274页

作者： Asaf Achiron Idan Hecht Chen Juza Adiel Barak Zvia Burgansky-Eliash Department of Ophthalmology Edith Wolfson Medical Center62 Halochamim St58100 HolonIsrael Sackler School of Medicine Tel Aviv UniversityTel AvivIsrael Department of Urology Tel Aviv Sourasky Medical CenterTel AvivIsrael Department of Ophthalmology Tel Aviv Sourasky Medical CenterTel AvivIsrael

Purpose:It has been suggested that Sildenafil may have beneficial therapeutic effects in the treatment of neurodegenerative *** retinal circulation is of significant interest as a marker of cerebral vascular disease since the retinal and cerebral vasculatures share many morphological and physiological properties,yet only the retinal circulation can be directly ***,our aim was to assess the change induced by Sildenafil on retinal blood ***:retinal flow velocity was measured 0.5,3 and 6 h following administration of 100 mg of Sildenafil using the retinal function ***:No clinical change in either systemic blood pressure or retinal flow velocities were ***,when controlling for heart rate and blood pressure,a significant drop in venous flow velocity 6 h following treatment(mean drop 0.3±0.07;95%CI:0.44–0.56,P=0.023)was ***:In healthy volunteers,retinal venous flow velocity was significantly reduced at the 6-h time point following Sildenafil *** effect was observed on arterial retinal flow velocity.

关键词： Sildenafil retinal function imager Autoregulation

retinal nerve fiber layer (RNFL) integrity and its relations to retinal microvasculature and microcirculation in myopic eyes

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Eye and Vision 2018年第1期5卷 223-232页

作者： Dongyi Qu Ying Lin Hong Jiang Yi Shao Yingying Shi Shriya Airen Giovanni Gregori Jianhua Wang Bascom Palmer Eye Institute University of Miami Miller School of MedicineMiamiFLUSA State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhouGuangdongChina Department of Neurology University of Miami Miller School of MedicineMiamiFLUSA College of Arts and Sciences University of MiamiMiamiFLUSA Department of Ophthalmology Bascom Palmer Eye Institute 1638 NW 10th AvenueMcKnight Building-Room 202AMiamiFL 33136USA

Background:The aim was to determine retinal nerve fiber layer function and its relations to retinal microvasculature and microcirculation in patients with ***:Polarization-sensitive optical coherence tomography(PS-OCT)was used to measure phase retardation per unit depth(PR/UD,proportional to the birefringence)of the retinal nerve fiber layer(RNFL).Optical coherence tomography angiography(OCTA)was used to measure macular vessel density analyzed using fractal *** addition,a retinal function imager(RFI)was used to measure macular blood flow velocities in arterioles and ***-two patients with moderate myopia(MM,refraction>3 andretinal blood flow velocities in arterioles and venules among groups(P>0.05).The macular vessel density in both superficial and deep vascular plexuses was significantly lower in the HM group than in the other two groups(P0.05).Conclusions:The impairment of the retinal nerve fiber birefringence in the HM group may be one of the independent features in high myopic eyes,which appeared not to relate to macular microvascular density and blood flow velocity.

关键词： Myopia retinal nerve fiber layer Polarization-sensitive optical coherence tomography retinal blood flow velocity retinal function imager retinal microvasculature Optical coherence tomography angiography

Microcirculation in the conjunctiva and retina in healthy subjects

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Eye and Vision 2019年第1期6卷 81-86页

作者： Ce Shi Hong Jiang Giovana Rosa Gameiro Jianhua Wang School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhouZhejiangChina Bascom Palmer Eye Institute University of MiamiMiller School of Medicine1638 NW 10th AvenueMcKnight Building-Room 202AMiamiFL 33136USA

Background:The aim was to determine the relationship between bulbar conjunctival microcirculation and retinal microcirculation in a healthy ***:A functional slit-lamp biomicroscope(FSLB)was used to measure blood flow velocity(BFV)and blood flow rate(BFR)in the conjunctiva while a retinal function imager(RFI)was used to measure macular BFV and BFR in the *** eye of each subject of 58 self-reported healthy subjects was imaged in the same session on the same ***:The mean BFV in the venules of the conjunctiva was 0.49±0.13 mm/s,which was significantly slower than that in the retinal arterioles(3.71±0.78 mm/s,Pretinal venules(2.98±0.58 mm/s,P0.05).Conclusion:The microcirculation in the retina appeared to be different from that in the conjunctiva.

关键词： Variability Bulbar conjunctiva Blood flow velocity Microvascular network functional slit-lamp biomicroscopy(FSLB) Hemodynamics Microcirculation Retina Conjunctiva retinal function imager