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Novel markers in predicting Brucella sacroiliitis:The platelet large cell ratio and basal immature reticulocyte fraction

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Asian Pacific Journal of Tropical Medicine 2023年第1期16卷 39-44页

作者： Neslihan Celik Esra Laloğlu Hülya Aslan Depertmant of Infection Diseases and Clinical Microbiology Health Sciences University Erzurum Regional Education and Research HospitalErzurumYakutiyeTurkey Department of Biochemistry Ataturk University School of Medicine25240ErzurumYakutiyeTurkey Depertmant of Microbiology Health Sciences University Erzurum Regional Education and Research HospitalErzurumYakutiyeTurkey

Objective:To present platelet large cell ratio(P-LCR),reticulocyte,and immature reticulocyte fraction(IRF)values as novel parameters in diagnosis and response to treatment in patients developing ***:Sixty-eight patients with clinical symptoms and Brucella standard tube agglutination(Wright)or Brucella Coombs agglutination test titers≥1:160 were included in the *** groups were established,one developing sacroiliitis and another with no sacroiliitis development.P-LCR,reticulocyte,and IRF levels were measured using a Sysmex XN-9000 device(Japan).These were then compared between the two ***:reticulocyte(P=0.037)and IRF(P=0.026)levels were significantly lower among the patients developing sacroiliitis compared to the non-sacroiliitis group,while P-LCR(P=0.003)levels were significantly higher.P-LCR had the most powerful correlation with sacroiliitis *** negative correlation was observed between reticulocyte,IRF levels and ***:Elevated P-LCR levels were observed as a marker of persisting inflammation in patients developing sacroiliitis,while low reticulocyte and IRF levels secondary to bone marrow involvement were *** three parameters emerged as highly significant markers in terms of diagnosis and reflecting responses to treatment in organ involvement such as sacroiliitis in *** are presented as inexpensive,and easily accessible novel parameters.

关键词： Brucella sacroiliitis P-LCR reticulocyte IRF

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EXISTENCE OF THE CELL GROWTH INHIBITOR IN RABBIT reticulocyte

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Chinese Science Bulletin 1989年第20期34卷 1740-1746页

作者：刘友华薛社普 Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing

*** Cell proliferation and differentiation are modulated by various regulators. It is well documented that loss control of any one of the key steps in the regulation of normal cell proliferation would cause abnormal cell growth even result in malignant ***, besides the well-known growth factor which is of positive regulation for cell proliferation, growth inhibitors with negative effect on cell growth are also isolated from vari-

关键词： growth inhibiter reticulocyte L929 cell

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reticulocyte hemoglobin content in the diagnosis of iron deficiency in Chinese pre-menopausal women

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Chinese Medical Journal 2007年第11期120卷 1010-1012页

作者： LUO Dan CHEN Yu WU Wei ZHANG Feng XU Jia CUI Wei LI Shu-lan LI Rong-sheng Department of Clinical Laboratory General Hospital of Air Force Beijing 100036 China Department of Clinical Laboratory Peking Union Medical College Hospital Chinese Academic of Medical Science ＆ Peking Union Medical College Beijing 100730 China Department of Hematology Peking Union Medical College Hospital Chinese Academic of Medical Science ＆ Peking Union Medical College Beijing 100730 China

Pre-menopausal women are at risk for iron deficiency due to menstrual blood losses. The prevalence rates （PR） of iron depletion, iron deficiency anemia （IDA）, and iron deficiency were 34.4%, 15.1% and 49.5% in pre-menopausal non-pregnant women respectively in China.1 Traditionally, the diagnosis of iron deficiency relies on the hematological markers （hemoglobin （HGB）, mean corpuscular volume （MCV）, mean corpuscular hemoglobin （MCH）, red cell distribution width （RDW）） and biochemical markers （serum ferritin （SF）, serum iron （SI）, transferrin saturation （TS）, total iron-binding capacity （TIBC））. Recently, the reticulocyte hemoglobin content （CHr） is considered to be used as a marker of iron deficiency.2 The aim of this study was to compare the diagnostic efficiency of CHr with the old markers in diagnosis of iron deficiency in Chinese pre-menopausal women.

关键词： reticulocyte iron deficiency iron deficiency anemia

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STUDIES ON THE REGULATION OF MALIGNANT PHENOTYPE AND GENE EXPRESSION IN HUMAN PROMYELOCYTIC LEUKEMIA CELL MUTANT （HL-60-AR）*

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Science in China,Ser.B 1988年第9期31卷 1095-1108页

作者：薛社普刘友华 Institute of Basic Medical Sciences Chinese Academy of Medical Sciences Beijing

The present study has investigated the regulation of malignant phenotype and gene expression in a human promyelocytic leukemia cell mutant （HL-60-AR） by means of cellular engineering technique of cybridization between the fusions of the mutant cells with enucleated mouse reticulocytes. Results indicate that the cybrid cells （HL-R） incorporated with reticulocyte cytoplasts become differentiated, and the malignancy is obviously suppressed or reversed to a certain degree when compared with those of parental tumor cells. They lose the growth ability to form colony soft agar medium, become non-tumorigenic under heterotransplantation to nude mice, and are accompanied by decrease in growth rate, cellular mitotic index and DNA synthesis. No gene transcripts or homologous sequence of mRNA corresponding to c-myc oncogene can be detected in cybrid cells by Northern blot technique with cloned cmyc gene probe, suggesting that the expression of originally active c-myc has been inhibited. On the other hand, analysis,

关键词： eybrid reticulocyte human leukemia cells oncogeue hemoglobin.

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615近交系小鼠血红蛋白遗传学分析

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Current Zoology 1986年第3期32卷 220-225页

作者：王立李洲黄丽华中国医学科学院血液学研究所

本文对615近交系及C;7BL、昆明种小鼠血红蛋白的表型进行了分析,观察到615小鼠及C;7BL小鼠的血红蛋白的表型均为Ⅰ型,而昆明种表现具有多态性。 615小鼠与C;7BL杂交时F;不发生血红蛋白表型的分离,而与昆明种的Ⅱ型小鼠杂交时F;表型发生... 详细信息

本文对615近交系及C;7BL、昆明种小鼠血红蛋白的表型进行了分析,观察到615小鼠及C;7BL小鼠的血红蛋白的表型均为Ⅰ型,而昆明种表现具有多态性。 615小鼠与C;7BL杂交时F;不发生血红蛋白表型的分离,而与昆明种的Ⅱ型小鼠杂交时F;表型发生分离。 615系小鼠网织红细胞体外培育合成血红蛋白肽链的分子同末梢红细胞血红蛋白肽链是一致的。

关键词： Hemoglobin Globin Inbred mouse reticulocyte Pheuylhydrazine.

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