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Thyrotoxicity of the Chlorides of Cadmium and Mercury in Rabbit

Biomedical and Environmental Sciences 1992年第3期5卷 236-240页

作者： NINA GHOSH SHELLEY BHATTACARYA Environmental Toxicology Laboratory Department of Zoology Visva-Bharati UniversityEnvironmental Toxicology Laboratory Department of Zoology Visva-Bharati University Santiniketan-731235 IndiaSantiniketan-731235 India

Exposure to heavy metals such as cadmium and mercury is of immediate environmental concern. The present study was aimed at establishing a direct relationship between heavy metal poisoning and thyroid dysfunction. Cadmium and mercury treatment at LD50 levels resulted in severe thyrotoxicosis in the rabbit. Within 24 h of intramuscular administration of cadmium chloride 15 mg-kg-1 body weight (bw) and mercury chloride 20 ***-1 bw, thyroid peroxidase activity increased significantly over the control with a concomitant rise in the triiodothyronine (T3) titre. On the other hand, there was a remarkable fall in the thyroxine (T4) level, and the T3/T4 ratio was high as compared with the control. Evidence indicates that acute heavy metal lethality will induce unmediate hyperthyroidism. It is suggested that T3-toxicosis may be produced by a preferential synthesis of T3 and/or preferential deiodination of T4 to T3. Measurement of T3 and T4 levels may thus be utilized as a reliable indicator of heavy metal lethality.

关键词： Exposure to heavy metals such as cadmium and mercury is of immediate environmental concern. The present study was aimed at establishing a direct relationship between heavy metal poisoning and thyroid dysfunction. Cadmium and mercury treatment at LD_(50) levels resulted in severe thyrotoxicosis in the rabbit. Within 24 h of intramuscular administration of cadmium chloride 15 mg·kg~(-1) body weight (bw) and mercury chloride 20 mg·kg~(-1) bw thyroid peroxidase activity increased significantly over the contro...

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Sustainable High-Performance Resilient Structures

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Engineering 2019年第2期5卷 197-198页

作者： Hong Hao Jun Li ARC Laureate Fellow John Curtin Distinguished Professor School of Civil and Mechanical Engineering Curtin University WA 6102 Australia Senior Lecturer School of Civil and Mechanical Engineering Curtin University WA 6102 Australia

Natural and human-made disasters such as earthquakes, tsunamis, typhoons, floods, blasts, and impacts have resulted in more than 1.1 million deaths, affected the lives of more than 2 billion people, and caused an estimated 1.5 trillion USD in damage worldwide between 2003 and 2013. The 2008 Wenchuan earthquake killed 69226 people and left 17923 unaccounted for, it caused a direct loss of 140 billion USD.

关键词： Natural and human-made earthquakes impacts have resulted

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