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responsiveness of the Chinese Quality of Life Instrument in Patients with Congestive Heart Failure

Chinese Journal of Integrative Medicine 2008年第3期14卷 173-179页

作者：赵利梁国辉刘凤斌陈洁陈金泉 School of Chinese Medicine The Chinese University of Hong Kong Department of Occupational Therapy Queen Elizabeth Hospital The First Affiliation Hospital Guangzhou University of Traditional Chinese Medicine School of Applied Sciences University of WolverhamptonUnited Kingdom

Objective： The Chinese Quality of Life Instrument （ChQOL） was developed as a valid generic health status instrument based on the well-established theory of health in Chinese medicine. Psychometric properties of the ChQOL were good. In the present study, the responsiveness of the ChQOL in patients with congestive heart failure （CHF） were investigated and compared with two generic questionnaires, the Medical Outcomes Study Short Form 36-item Health Survey （SF-36） and World Health Organization Quality of Life Assessment （WHOQOL-BREF）, as well as one disease-specific questionnaire, the Minnesota Living with Heart Failure Questionnaire （MLHF）. Methods： Thirty-nine in-patients with CHF who had undergone treatment with integrative medicine were recruited. The health status measurements were performed at enrolment and after a 4-week treatment. The following responsiveness indices were used： the effect size （ES） and standardized response mean （SRM）. All patients were classified into those groups with stable measures and those groups with changes after a 4-week treatment, based upon both the doctor＇s global rating of changes in heart function tests, and the patient＇s global rating of changes in overall quality of life. Results： All domains of the ChQOL showed significant improvement. In the comparison of the responsiveness indices, the ChQOL was regarded as more responsive than the WHOQOL-BREF or SF-36 utility, but it was less responsive than the MLHF. Conclusions： The ChQOL was better in sensitivity and responsiveness for assessing congestive heart failure as a generic measure than the SF-36 and WHOQOL-BREF. The ChQOL is considered suitable as an outcome measure for clinical trials in patients with congestive heart failure.

关键词： responsiveness Chinese Quality of Life Instrument congestive heart failure

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responsiveness and minimal clinically important difference of the Chinese version of the Low Vision Quality of Life Questionnaire after cataract surgery

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 504-509页

作者： Wen-Wen Xue Pei Zhang Hai-Dong Zou Department of Ophthalmology Shanghai Eye Diseases Prevention and Treatment Center Department of Ophthalmology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Department of Ophthalmology Shanghai Gonghui Hospital

AIM: To investigate the Chinese version of the Low Vision Quality of Life Questionnaire(CLVQOL) as an instrument for obtaining clinically important changes after cataract ***: Patients underwent cataract surgery in Shanghai General Hospital, Shanghai Jiao Tong University, who fit the inclusion criteria were recruited. Two CLVQOLs were administered, including a preoperative CLVQOL and a CLVQOL at the end of the 3 mo follow-up period, and were completed using face-to-face interviews or phone interviews conducted by trained investigators. The minimal clinically important difference(MCID) was calculated using an anchor-based method and a distribution method. In addition, the responsiveness of the questionnaire was ***: A total of 155 residents were enrolled. The average visual acuity(VA) preoperatively was 0.08(SD=0.05), and it increased to 0.47(SD=0.28) at the end of followup. Statistically significant positive changes in the CLVQOL scores indicated significant improvement of vision related quality of life after cataract surgery. With the larger value between the two results as the final value, the MCID values of the CLVQOL(scores of the four scales as well as the total score) were 8.94, 2.61, 4.34, 3.10 and 17.63, respectively. The CLVQOL has both good internal and external ***: CLVQOL scores are appropriate instruments for obtaining clinically important changes after cataract surgery. This study is an effective exploration for establishingcataract surgery efficacy standards, which helps clinical and scientific research workers in ophthalmology to gain a more in-depth understanding when using CLVQOL.

关键词： responsiveness minimal clinically important difference Chinese Version of the Low Vision Quality of Life Questionnaire Chinese

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Resolving the GPU responsiveness dilemma through program transformations

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Frontiers of Computer Science 2018年第3期12卷 545-559页

作者： Qi ZHU Bo WU Xipeng SHEN Kai SHEN Li SHEN Zhiying WANG National Key Laboratory of High Performance Computing National University of Defense Technology Changsha 410073 China Jiangnan Institute of Computing Technology Wuxi 214083 China Department of Computer Science North Carolina State University Raleigh NC 27695 USA EECS Colorado School of Mines Golden CO 80401 USA Department of Computer Science University of Rochester Rochester NY 14627 USA

The emerging integrated CPU-GPU architectures facilitate short computational kernels to utilize GPU acceleration. Evidence has shown that, on such systems, the GPU control responsiveness （how soon the host program finds out about the completion of a GPU kernel） is essential for the overall performance. This study identifies the GPU responsiveness dilemma： host busy polling responds quickly, but at the expense of high energy consumption and interference with co-running CPU programs; interrupt-based notification minimizes energy and CPU interference costs, but suffers from substantial response delay. We present a programlevel solution that wakes up the host program in anticipation of GPU kernel completion. We systematically explore the design space of an anticipatory wakeup scheme through a timerdelayed wakeup or kernel splitting-based pre-completion notification. Experiments show that our proposed technique can achieve the best of both worlds, high responsiveness with low power and CPU costs, for a wide range of GPU workloads.

关键词： program transformation GPU integrated architecture responsiveness

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Transcriptomic analysis in Anemone flaccida rhizomes reveals ancillary pathway for triterpene saponins biosynthesis and differential responsiveness to phytohormones

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Chinese Journal of Natural Medicines 2019年第2期17卷 131-144页

作者： MO Guo-Yan HUANG Fang FANG Yin HAN Lin-Tao Kayla K.Pennerman BU Li-Jing DU Xiao-Wei Joan W.Bennett YIN Guo-Hua China Key Laboratory of TCM Resource and Prescription Ministry of EducationHubei University of Chinese Medicine Department of Plant Biology and Pathology RutgersThe State University of New Jersey Department of Biology University of New Mexico Department of Pharmacy Heilongjiang University of Chinese Medicine

Anemone flaccida Fr. Schmidt is a perennial medicinal herb that contains pentacyclic triterpenoid saponins as the major bioactive constituents. In China, the rhizomes are used as treatments for a variety of ailments including arthritis. However, yields of the saponins are low, and little is known about the plant's genetic background or phytohormonal responsiveness. Using one-quarter of the 454 pyrosequencing information from the Roche GS FLX Titanium platform, we performed a transcriptomic analysis to identify 157 genes putatively encoding 26 enzymes involved in the synthesis of the bioactive compounds. It was revealed that there are two biosynthetic pathways of triterpene saponins in A. flaccida. One pathway depends on β-amyrin synthase and is similar to that found in other plants. The second, subsidiary("backburner") pathway is catalyzed by camelliol C synthase and yields β-amyrin as minor byproduct. Both pathways used cytochrome P450-dependent monooxygenases(CYPs) and family 1 uridine diphosphate glycosyltransferases(UGTs) to modify the triterpenoid backbone. The expression of CYPs and UGTs were quite different in roots treated with the phytohormones methyl jasmonate, salicylic acid and indole-3-acetic acid. This study provides the first large-scale transcriptional dataset for the biosynthetic pathways of triterpene saponins and their phytohormonal responsiveness in the genus Anemone.

关键词： Anemone flaccida Fr.Schmidt Triterpenoid saponins Biosynthetic pathways Transcriptomic analysis Phytohormonal responsiveness

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Molecular Characterization of Thyroid Hormone Receptors (TRs) and their responsiveness to T3 in Microhylafissipes

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Asian Herpetological Research 2018年第1期9卷 13-23页

作者： Lusha LIU Xungang WANG Mengjie ZHANG Jianping JIANG Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 Sichuan China University of Chinese Academy of Sciences Beijing 100049 China College of Life Sciences Nanjing Normal University Nanjing 210023 Jiangsu China

To explore and enrich the molecular mechanisms of thyroid hormone receptors （TRs） in the metamorphosis of amphibians, the cDNA sequences of TRa and TRβ in Microhyla fissipes were cloned and characterized. TRa was 1 706 bp in length with an open reading frame （ORF） of 1 257 bp encoding a predicted protein of 418 amino acids and TRβ was 1 422 bp with an ORF of 1 122 bp encoding a predicted protein of 373 amino acids. Their protein sequences contained 4 conserved domains of the nuclear receptor superfamily with two highly conserved cysteine-rich zinc fingers in the DNA-binding domain, whereas TRβ was 42 amino acids shorter in its A/B domain than TRot. Highly-conserved sequences and structures indicated their conserved functions during metamorphosis. TRa expression reached peak at 12 h and then decreased from 12 h to 48 h. While dramatically up-regulated TRβ was observed after exposure of T3 within 24 h, and it was down-regulated from 24 h to 48 h. The expression pattern of TRβ is similar to that in the natural metamorphosis. Furthermore, tadpoles treated 24 h also resembled the climax of metamorphosis tadpoles and TRβ expression had higher responsiveness than TRa to T3 in M. fissipes. These results suggest M. fissipes may serve as the model to assay environmental compounds on TH signaling disruption.

关键词： Microhylafissipes thyroid hormone receptors functional characteristic expression pattern responsiveness

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Remodeled structure and reduced contractile responsiveness of ocular ciliary artery in spontaneously hypertensive rats

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 363-368页

作者： Ya-Ru Dong Claire E Gustafson Jun Wang Ji-Zhe Cui Takeshi Yoshitomi Department of Ophthalmology the Second Hospital of Jilin University Department of Ophthalmology Akita University School of Medicine Division of Immunology and Rheumatology Department of Medicine Stanford University

AIM: To investigate the alterations in both structure and contractile responsiveness of ocular ciliary artery(OCA) in spontaneously hypertensive rat(SHR).METHODS: In this experiment, 20-week-old male SHR and Wistar Kyoto rat(WKY) were studied. The heart rate(HR), the blood pressure(BP; the systolic BP and the diastolic BP) of rats with an electronic sphygmomanometer were measured. Vascular morphometry and isometric tension measurement were used to investigate the alterations in structure and contractility of ***: A general narrowing of OCAs was observed in SHR compared to the control WYK. In SHR, the media of OCAs were thicker, the luminal diameters were smaller, and the media-to-lumen ratios were higher when compared with WKY(P0.05). Indomethacin(10 μmol/L) decreased the contractions induced by norepinephrine in OCAs from WKY(P0.05).CONCLUSION: Our results demonstrate that the structure and function of OCAs are altered in hypertension. OCAs from SHR are remodeled with decreased lumen diameter and increased media-to-lumen ratio. Moreover, the contractile responsiveness of OCAs from SHR is diminished due to the disruption of vasoconstrictive effect of prostaglandins.

关键词： remodeled structure contractile responsiveness ocular ciliary artery hypertension spontaneously hypertensive rat

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Individual Differences in Stress responsiveness of the Hypothalamic-Pituitary-Adrenal Axis and Its Vasopressinergic Regulation in Old Monkeys

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Journal of Behavioral and Brain Science 2015年第7期5卷 280-294页

作者： Nadezhda D. Goncharova Victor Yu. Marenin Tamara E. Oganyan Laboratory of Endocrinology Federal State Budgetary Scientific Institution “Research Institute of Medical Primatology” Sochi Russia

Stress adaptation is fundamental for health, and the hypothalamic-pituitary-adrenal axis (HPA) is one of its main mechanisms. Considerable data indicate that arginine vasopressin (AVP) related disturbances of stress adaptation can occur with aging. However, most studies of such kind have been performed on rodents, give contradictory results and fail to consider individual characteristics of the animals. The purpose of this study was to investigate individual HPA responsiveness to acute stress and its vasopressinergic regulation in old female rhesus monkeys that differ in their behavioral responses to stress. Animals with depression-like or anxiety-like behavior (DAB) responded with higher plasma levels of ACTH and AVP, lower levels of corticosteroids and higher cortisol/DHEAS molar ratios to restraint stress and to insulin-induced hypoglycemia compared with animals with healthy adaptive behavior. AVP and ACTH dynamics were closely correlated in most animals. AVP treatment produced differences in HPA responses similar to those produced by the stressors. The ACTH response to hypoglycemic stress in the DAB animal with highest HPA responsiveness was dramatically reduced by prior administration of a V1b receptor antagonist. These results suggest that the dysfunctions of HPA observed in old animals with DAB are caused by increased tone of the vasopressinergic system in regulation of HPA stress reactivity.

关键词： Hypothalamic-Pituitary-Adrenal Axis Stress responsiveness Vasopressinergic Regulation Different Types of Adaptive Behavior Aging

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Meta-Analysis of Ventilated versus Spontaneously Breathing Patients in Predicting Fluid responsiveness by Inferior Vena Cava Variation

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International Journal of Clinical Medicine 2018年第10期9卷 760-777页

作者： Xiang Si Daiyin Cao Hailin Xu Xiangdong Guan Department of Surgical Intensive Care Unit The First Affiliated Hospital of Sun Yat-sen University Guangzhou China Department of Critical Care Medicine The Sixth Affiliated Hospital of Sun Yat-sen University Guangzhou China Transplantation Department The Second Affiliated Hospital of Guangzhou Medical University Guangzhou China

Purpose: Respiratory variation in inferior vena cava (ΔIVC) has been extensively studied in predicting fluid responsiveness, but the results are conflicting. We performed a systemic review and meta-analysis of studies aiming at investigating the diagnostic accuracy of ΔIVC in predicting fluid responsiveness. Methods: MEDLINE, EMBASE, Cochrane Database and Web of Science were screened for relevant original and review articles from inception to July 2016. The meta-analysis determined the pooled sensitivity, specificity, diagnostic odds ratio (DOR) and area under the ROC curve (AUROC). In addition, subgroup analyses were performed in mechanically ventilated patients and spontaneously breathing patients. Results: A total of 20 studies involving 635 patients were included. Cutoff values of ΔIVC varied from 12% to 42%, the pooled sensitivity and specificity was 0.68 (0.62 - 0.75) and 0.80 (0.75 - 0.85), respectively. The DOR was 14.2 (6.0 - 33.6) and the AUROC was 0.86 (0.78 - 0.93). Subgroup analysis showed better diagnostic performance in patients on mechanical ventilation than in spontaneously breathing patients with higher sensitivity (0.75 vs. 0.56), specificity (0.82 vs. 0.78), DOR (22.9 vs. 7.9) and AUROC (0.90 vs. 0.80). The best threshold of ΔIVC in patients on mechanical ventilation was IVC distensibility index (ΔIVC ≥17% ±4%), compared to IVC collapsibility index (ΔcIVC ≥33% ±12%) in spontaneously breathing patients. Conclusion: ΔIVC is not an accurate predictor of fluid responsiveness in patients with acute circulatory failure. In patients on mechanical ventilation, the predicting ability of ΔIVC was moderate with acceptable sensitivity and specificity;in spontaneously breathing patients, the specificity remains acceptable but its sensitivity is poor.

关键词： Fluid responsiveness Inferior Vena Cava Variation

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Achieving responsiveness through Supply Chain Integration:A Moderating Effect of Industry-4.0

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Journal of Business Administration Research 2019年第4期2卷 20-32页

作者： Dawei Lu Xuemei Fan Peiqing Cao University of Warwick UK Jilin University jilin130000China

This article is aiming to investigate the emerging impact of industry-4.0 on supply chain integration and responsiveness in the electronics industry in ***,it is to investigate the moderating effect of industry-4.0 as a strategic factor on the causal relationship from operational integration to supply chain *** study develops hypotheses based the on selected literature reviews in the relevant research areas,and tests the hypotheses in the empirical sample data set collected from 76 electronics firms by using hierarchical multiple regression *** results of this study shows that industry-4.0 as an emerging strategic factor has not only directly helped the level of market responsiveness of the firms,but also has significantly strengthens the already proven positive causal relationship from operational integration within the supply chain to the overall market responsiveness as part of supply chain *** improve the supply chain responsiveness in the electronics industry,managers can now make more confident and informed decisions to channel their resources towards the initiatives of industry-4.0 by up-grading perhaps their current information systems and business processes,knowing full well the dual benefits offered by the Industry 4.0 *** study extends the concurrent literature by conceptualising the moderating effect of industry-4.0 on the causal relationship between supply chain integration and business responsiveness.

关键词： Supply chain Integration responsiveness Industry-4.0

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Dynamic-Distributed Load Balancing for Highly-Performance and responsiveness Distributed-GIS (D-GIS)

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Journal of Geographic Information System 2011年第2期3卷 128-139页

作者： Aissatou Diasse Foroski Kone 不详

In recent years, several results have been introduced to enhance distributed GIS performance. While much more efforts have focused on tile map and simple symbologies on dynamic map, load balancing GIS servers have not been addressed by the GIS community so far. This paper, therefore, proposed dynamic distributed load balancing for D-GIS in order to quickly render information to client interface by involving a set of GIS servers which process clients’ requests depending of an algorithm. In the model, several concepts were introduced and defined: Virtual Server within physical machine which constitutes a setup environment for a single GIS server, Load Hash Table which contains information about virtual server’s capacity, real-time load and other mandatory elements, Request Split Table which splits requests depending of the input area’s Quantity of Information and stores request tasks composition for later reconstitution. At last we have Distributed Failover Callback Function Table level one (respectively level two) which determines whether or not the request had been successfully processed by the chosen virtual server (respectively physical machine). This table allows sending back the same request to another virtual server (respectively physical node). Two load handlers (primary and secondary) are defined in case of failure. Our Model achieves efficient load balancing by: providing efficient node selection;optimizing request routing;managing node failover;involving client’s request partitioning and introducing method type decomposition. A simulation of the algorithm shows a low response time when performing GIS operations.

关键词： Load Balancing Distributed-GIS Performance responsiveness

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