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Effects of Tualang honey in modulating nociceptive responses at the spinal cord in offspring of prenatally stressed rats

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Journal of Integrative Medicine 2019年第1期17卷 66-70页

作者： Che Badariah Abd Aziz Siti Qusyasyiah Ahmad Suhaimi Hidani Hasim Asma Hayati Ahmad Idris Long Rahimah Zakaria Department of Physiology School of Medical Sciences Health Campus Universiti Sains Malaysia School of Health Sciences Health Campus Universiti Sains Malaysia

Objective: This study was done to determine whether Tualang honey could prevent the altered nociceptive behaviour, with its associated changes of oxidative stress markers and morphology of the spinal cord,among the offspring of prenatally stressed rats.Methods: Pregnant rats were divided into three groups: control, stress, and stress treated with Tualang honey. The stress and stress treated with Tualang honey groups were subjected to restraint stress from day 11 of pregnancy until delivery. Ten week old male offspring(n = 9 from each group) were given formalin injection and their nociceptive behaviours were recorded. After 2 h, the rats were sacrificed, and their spinal cords were removed to assess oxidative stress activity and morphology. Nociceptive behaviour was analysed using repeated measures analysis of variance(ANOVA), while the levels of oxidative stress parameters and number of Nissl-stained neurons were analysed using a one-way ANOVA.Results: This study demonstrated that prenatal stress was associated with increased nociceptive behaviour, changes in the oxidative stress parameters and morphology of the spinal cord of offspring exposed to prenatal stress; administration of Tualang honey reduced the alteration of these parameters.Conclusion: This study provides a preliminary understanding of the beneficial effects of Tualang honey against the changes in oxidative stress and neuronal damage in the spinal cord of the offspring of prenatally stressed rats.

关键词： Prenatal stress Nociceptive responses Tualang honey Spinal cord

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Common mycorrhizal networks activate salicylic acid defense responses of trifoliate orange(Poncirus trifoliata)

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Journal of Integrative Plant Biology 2019年第10期61卷 1099-1111页

作者： Yi-Can Zhang Ying-Ning Zou Li-Ping Liu Qiang-Sheng Wu College of Horticulture and Gardening Yangtze University Jingzhou 434025 China Institute of Root Biology Yangtze University Jingzhou 434025 China Department of Chemistry Faculty of Science University of Hradec Kralove Hradec Kralove 50003 Czech Republic

Citrus canker, caused by Xanthomonas axonopo-dis pv. citri ('Xac'), is an important quarantine disease in citrus crops. Arbuscular mycorrhizal fungi (AMF) form symbiotic interactions with host plants and further affect their disease resistance, possibly by modulating the activity of salicylic acid (SA), a key phytohormone in disease resistance. Common mycorrhizal networks (CMNs) can interconnect plants, but it is not yet clear whether CMNs promote resistance to citrus canker and, if so, whether SA signaling is involved in this process. To test this possibility, we used a two-chambered rootbox to establish CMNs between trifoliate orange (Poncirus trifoliata) seedlings in chambers inoculated (treated) or not (neighboring) with the AMF, Paraglomus occultum. A subset of the AMF-inoculated seedlings were also inoculated with Xac (+AMF+Xac). At 2 d post-inoculation (dpi), compared with the +AMF-Xac treatment, neighboring seedlings in +AMF+Xac treatment had lower expression levels of the SA biosynthetic genes, PtPAL, PtEPS1, and PtPBS3, but higher SA levels, which attributed to the upregulation of PtPAL and PtPBS3 in treated seedlings and the transfer of SA, via CMNs, to the neighboring seedlings. At 4 dpi, the pathogenesis-related (PR) protein genes, PtPR1, PtPR4, and PtPR5, and the transcriptional regulatory factor gene, PtNPR1, were activated in neighboring seedlings of+AMF+Xac treatment. At 9 dpi, root phenylalanine ammo-nia-lyase activity and total soluble phenol and lignin concentrations increased in neighboring seedlings of+AMF+Xac treatment, likely due to the linkage and signal transfer, via CMNs. These findings support the hypothesis that CMNs transfer the SA signal from infected to neighboring healthy seedlings, to activate defense responses and affording protection to neighboring plants against citrus canker infection.

关键词： Poncirus trifoliata mycorrhizal salicylic acid defense responses

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PXR variants:the impact on drug metabolism and therapeutic responses

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Acta Pharmaceutica Sinica B 2016年第5期6卷 441-449页

作者： C.Trent Brewer Taosheng Chen Department of Chemical Biology and Therapeutics St.Jude Children's Research Hospital Integrated Biomedical Sciences Program University of Tennessee Health Science Center

The pregnane X receptor(PXR) plays an important and diverse role in mediating xenobiotic induction of drug-metabolizing enzymes and transporters.Several protein isoforms of PXR exist,and they have differential transcriptional activity upon target genes; transcript variants 3(PXR3) and 4(PXR4) do not induce target gene expression,whereas transcript variants 1(PXR1) and 2(PXR2) respond to agonist by activating target gene expression.PXR protein variants also display differences in protein–protein interactions; PXR1 interacts with p53,whereas PXR3 does not.Furthermore,the transcript variants of PXR that encode these protein isoforms are differentially regulated by methylation and deletions in the respective promoters of the variants,and their expression differs in various human cancers and also in cancerous tissue compared to adjacent normal tissues.PXR1 and PXR4 m RNA are downregulated by methylation in cancerous tissue and have divergent effects on cellular proliferation when ectopically overexpressed.Additional detailed and comparative mechanistic studies are required to predict the effect of PXR transcript variant expression on carcinogenesis,therapeutic response,and the development of toxicity.

关键词： Pregnane X receptor Transcript variants Drug metabolism Therapeutic responses Toxicity

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Impaired CTLA-4 responses in COPD are associated with systemic inflammation

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Cellular & Molecular Immunology 2014年第6期11卷 606-608页

作者： Dino BA Tan Sonia Fernandez PatriciaPrice Martyn A French Philip J Thompson Yuben P Moodley Centre for Asthma Allergy and Respiratory Research Lung Institute of Western Australia Nedlands Australia School of Medicine and Pharmacology Nedlands Australia School of Pathology and Laboratory Medicine University of Western Australia Nedlands Australia Department of Clinical Immunology Perth Australia Department of Respiratory and Sleep Medicine Royal Perth Hospital Perth Australia

Systemic inflammation is a feature of chronic obstructive pulmo- nary disease （COPD）. Defects in T cell-mediated anti-inflamma- tory pathways such as cytotoxic T lymphocyte antigen-4 （CTLA- 4） may promote damaging inflammation. This study provides novel data implicating the impaired induction of an anti-inflam- matory molecule, CTLA-4 in the elevated inflammation observed in COPD patients. Low induction of CTLA-4 in COPD patients paralleled increased markers of systemic inflammation ex vivo and increased T-cell responses to a bacterial superantigen, staphylo- coccal enterotoxin-B （SEB） in vitro. This mechanism may explain the increased inflammation in COPD patients.

关键词： Impaired responses associated

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Effect of heavy load carriage on cardiorespiratory responses with varying gradients and modes of carriage

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Military Medical Research 2019年第1期6卷 53-59页

作者： Subhojit Chatterjee Tirthankar Chatterjee Debojyoti Bhattacharyya Suranjana Sen Madhusudan Pal Defence Institute of Physiology and Allied Sciences Defence Research & Development Organisation Ministry of Defence

Background: The present study was undertaken to determine the effect of different uphill and downhill gradients on cardiorespiratory and metabolic responses of soldiers while carrying heavy military loads in two different modes.Methods: Eight physically fit male soldiers with a mean age 32.0±2.0 years, a mean height of 169.5±4.9 cm, and a mean weight of 63.8±8.4 kg volunteered for this study. Each volunteer completed treadmill walking trials at a speed of 3.5 km/h while carrying no external load, 31.4 kg load in a distributed mode(existing load carriage ensembles) and compact mode(new back pack) over 5 different downhill and uphill gradients(–5%, –10%, 0%, 5%, 10%) for 6 min at each gradient. During the walking trials, heart rate(HR), oxygen uptake(VO_2), respiratory frequency(RF) and energy expenditure(EE) were determined by the process of breath-by-breath gas analysis using a K4 b2 system. The average of the last 2 min data from each 6 min walking trial for each individual was subjected to statistical analysis.Results: All parameters(HR, VO_2, RF, and EE) gradually increased with the change in gradient from downhill to level to uphill. The distributed mode showed higher values compared to compact mode for all gradients, e.g., for VO_2, there was a 10.7, 7.4, 5.1, 28.2 and 18.7% increase in the distributed mode across the 5 different gradients.Conclusions: It can be concluded from the present study that the compact mode of load carriage is more beneficial than the distributed mode in terms of cardiorespiratory responses while walking on downhill and uphill surfaces with a 31.4 kg load.

关键词： Heavy load carriage Cardio respiratory responses Gradients Soldiers

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Surface energy-mediated fibronectin adsorption and osteoblast responses on nanostructured diamond

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Journal of Materials Science & Technology 2019年第5期35卷 817-823页

作者： Yixing Tian Huiling Liu Brian W.Sheldon Thomas J.Webster Sichen Yang Huilin Yang Lei Yang Orthopaedic Institute and Department of Orthopaedics The First Affiliated Hospital Soochow University Suzhou Jiangsu 215006 China School of Engineering Brown University Providence RI 02912 USA Department of Chemical Engineering Northeastern University Boston MA. 02115 USA International Research Center for Translational Orthopaedics (IRCTO) Soochow University Suzhou Jiangsu 215006 China UWC Changshu China Changshu Jiangsu 215500 China

Nanostructured diamond have potential applications in many biomedical related fields and demonstrated extraordinary capacity to influence cellular responses. Studying the surface property of nanodiamond and its influence to protein adsorption and subsequent cellular responses along with the mechanism behind such capacity becomes more important. Here the role of surface energy associated with nanostructured diamond in modulating fibronectin and osteoblast(OB, bone forming cells) responses was investigated. Nanocrystalline diamond(NCD) and submicron crystalline diamond(SMCD) films with controllable surface energy were prepared by microwave-enhanced plasma chemical vapor deposition(MPCVD) techniques. Fibronectin adsorption on the diamond films with varied surface energy values was measured via the enzyme-linked immunosorbent assay(ELISA) and the relationship between the surface energy and fibronectin adsorption was studied. The result indicated that fibronectin adsorption on nanostructured surfaces was closely related to both surface energy and material microstructures. The spreading and migration of OB aggregates(each containing 30–50 cells) on the NCD with varied surface energy values were also studied. The result indicates a correlation between the cell spreading and migration on nanodiamond and the surface energy of nanostructured surface.

关键词： Nanostructure Diamond films Surface characteristics Protein adsorption Cell responses

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Clinical characteristic and fecal microbiota responses to probiotic or antidepressant in patients with diarrhea-predominant irritable bowel syndrome with depression comorbidity: a pilot study

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Chinese Medical Journal 2019年第3期132卷 346-351页

作者： Lu Zhang Yi-Xuan Liu Zhe Wang Xiao-Qi Wang Jing-Jing Zhang Rong-Huan Jiang Xiang-Qun Wang Shi-Wei Zhu Kun Wang Zuo-Jing Liu Huai-Qiu Zhu Li-Ping Duan Department of Gastroenterology Peking University Third HospitalBeijing 100191China Department of Biomedical Engineering College of Engineeringand Center for Quantitative BiologyPeking UniversityBeijing 100871China Department of Psychiatry Institute of Mental HealthPeking UniversityBeijing 100191China Department of Psychological Medicine Chinese People's Liberation Army (PLA)General HospitalBeijing 100853China

To the Editor: Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder that presents as abdominal pain with altered bowel habits. The pathophysiologic mechanism of IBS is not well understood, although many hypotheses have been proposed, including visceral hypersensitivity, gastrointestinal dysmotility, lowgrade inflammation of the intestinal mucosa, and dysfunction of the brain-gut interaction. Dysfunction of the braingut interaction is thought to be involved in IBS because a considerable proportion of patients with IBS have some form of psychologic comorbidity, such as depression or anxiety. In addition, mental and psychologic problems increase the risk for IBS and the symptom severity of IBS. Recently, changes in the gut microbiota have also been suggested to contribute to both IBS and depression. Our previous study demonstrated significant altered gut microbiota profiles in patients with diarrhea-predominant IBS (IBS-D) and depression.

关键词： fecal microbiota responses depression comorbidity diarrhea-predominant irritable bowel syndrome

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Enhancing the bake-hardening responses of a pre-aged Al-Mg-Si alloy by trace Sn additions

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Journal of Materials Science & Technology 2020年第5期40卷 107-112页

作者： Gang Lu Shuai Nie Jianjun Wang Ying Zhang Tianhai Wu Yujie Liu Chunming Liu Key Laboratory for Anisotropy and Texture of Materials(MoE) School of Materials Science and EngineeringNortheastern UniversityShenyang 110819China The State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang 110819China Research Center for Metallic Wires Northeastern UniversityShenyang 110819China Shenyang Industrial Transformation Upgrading Promotion Center Shenyang 110083China

Effects of additions of trace Sn on the bake-hardening responses of a pre-aged Al-0.85 Mg-0.85 Si(in wt%)alloy were investigated through mechanical tests,differential scanning calorimetry,electrical resistivity and transmission electron microscopy.Results indicate that trace Sn additions reduced the number density of pre-aging clusters by inhibiting the formation of unstable counterpart during pre-aging treatment,leading to low strength and high supersaturation of solute atoms.In a subsequent paint-bake treatment,the presence of highly supersaturated solute atoms and high concentrated free vacancies moderated the activation energy barrier ofβ’’phase and thus kinetically accelerated the formation ofβ’’.Consequently,the trace Sn additions enhanced the bake-hardening responses of the pre-aged alloys significantly.The Sn-containing pre-aged Al-Mg-Si alloys with low strength and great bake-hardening responses hold promising potential for automotive body skin applications.

关键词： Al-Mg-Si alloy Pre-aging Trace Sn Bake-hardening responses Precipitation kinetics

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Tm-2^2 Confers Different Resistance responses against Tobacco mosaic virus Dependent on Its Expression Level

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Molecular Plant 2013年第3期6卷 971-974页

作者： Haili Zhang Jinping Zhao Shanshan Liu Da-Peng Zhang Yule Liu MOE Key Laboratory of Bioinformatics School of Life Sciences Tsinghua University Beijing 100084 PR China

Dear Editor, The innate immunity system of plants can be summarized into two clades. The former clade, where resistant processes are mediated by pattern recognition receptors, is termed pathogen-associated molecular ... 详细信息

关键词： Tm-2~2 responses Expression

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Transcriptomic responses of Acinetobacter harbinensis HITLi 7~T at Low Temperatures

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Biomedical and Environmental Sciences 2019年第5期32卷 371-375页

作者： MA Yin Peng ZHANG Shu Mei MENG Li Qiang LI Wei Guang Institute of Microbiology Heilongjiang Academy of SciencesHarbin 150010HeilongjiangChina School of Environment Harbin Institute of TechnologyHarbin 150090HeilongjiangChina State Key Laboratory of Urban Water Resource and Environment Harbin 150090HeilongjiangChina

Acinetobacter harbinensis HITLi 7^T, a novel species in the genus Acinetobacter, was isolated from Songhua River in Harbin, China. It is a psychrotolerant heterotrophic nitrification bacterium that grows in temperatures from 2 ℃ to 35 ℃ with an optimal growth temperature of 8 ℃- 20 ℃[1]. The strain plays an important role in ammonium removal from source water and water sanitation improvement in cold areas. Biologically enhanced activated carbon (BEAC) filters immobilized with HITLi 7^T are used to treat source water in winter, exhibiting stronger ammonium removal capability and higher microbial stability during BEAC treatment at low temperatures[2]. However, the low temperature adaptation mechanism of HITLi 7^T has not been clearly elucidated yet.

关键词： Transcriptomic responses Acinetobacter

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