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VPS35 Protects Against TMEM230-mutation-induced Progressive Locomotor Deficits in Drosophila

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Neuroscience Bulletin 2022年第6期38卷 652-656页

作者： Chao Ma Xiaobo Wang Wanli W.Smith Zhaohui Liu Department of Human Anatomy and Cytoneurobiology School of Biology and Basic Medical SciencesSoochow UniversitySuzhou 215123China Department of Psychiatry and Behavioral Sciences Johns Hopkins University School of MedicineBaltimore 21287USA

The discovery of genes related to Parkinson's disease(PD)provides an imporant basis for the progress of research into PD,helps to clarify is mechanism,and provides many new opportunities to find therapeutic targelts[1.2].The article by Deng and colleagues in 2016 found a new autosomal dominant PD(ADPD)gene,transmembrane protein 230(TMEM230).Four PD-linked mutations were identifed in PD patients:Y92C,RI4IL.184Wexr*5(replacing the stop codon with six ***,in the C-terminus in North American patients),and 184PGext*5(replacing the stop codon with proline and glycine,thus adding seven amino acids,PGHPPHS,to the C-lerminus in Chinese families with PD)[3].Subsequenly,studies have suggested thal TMEM230 variants are related to PD pathogenesis in viro[4-6].

关键词： adding replacing families

Is tenecteplase ready to replace alteplase to treat acute ischaemic stroke? The knowns and unknowns

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Stroke & Vascular Neurology 2022年第1期7卷 1-5页

作者： Yi Dong Yi Sui Xin Cheng David Z Wang Department of Neurology Huashan Hospital Fudan UniversityShanghaiChina Department of Neurology Shenyang Brain HospitalShenyang Medical CollegeShenyangChina Department of Neurology The First People's Hospital of ShenyangShenyangChina Department of Neurology Barrow Neurological InstitutePhoenixArizonaUSA

Tenecteplase(TNKase,TNK-tPA or TNK)is a thrombolytic agent derived from the tissue plasminogen activator(tPA).It is a 527-amino acid glycoprotein developed by replacing three amino acids at the T,N and K positions of the glycoprotein structure of tPA under genetic recombinant *** replacing threonine 103 with asparagine,asparagine 117 with glutamine and a tetra-alanine at amino acids 296–299,TNK is about eightfold more potent in dissolving clot,80-fold higher resistance to plasminogen activator inhibitor-1 and 14-fold enhanced relative fibrin specificity,and with a longer half-life(20 min).1 Hence,TNK is administered as a single intravenous bolus.

关键词： technology replace replacing

Magnetic Properties and Application of Ultra-microcrystalline Fe_(73.9)Cu_1Nb_(1.1)Mo_2Si_(12)B_(10) Alloy

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Chinese Science Bulletin 1994年第1期39卷 87-88页

作者：张延忠年素珍 Shanghai Iron & Steel Research Institute Shanghai 200940 PRC

In Refs.[1] and [2], the superior magnetic properties have been reported for theexpensive synthetic ultra-microcrystalline Fe73.5Cu1Nb13Si13.5B9 and Fe73.1Cu12Nb3.2Si12.5B10alloys. Partly replacing the expensive Nb by... 详细信息

关键词： expensive replacing cheap diameters annealed transformer comparable outer switched dropped

On the Rotational Invariance of the INDO Method Including f Orbitals into the Basis Set

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高等学校化学学报(英文版) 1987年第2期 65-72页

作者： Ren Jiangqing Xu Guangxian (K.H. Hsu) (Department of Chemistry,Peking University)

In order to ensure the rotational invariance of the one-center-two-electron integrals in the INDO method including f orbitals into the basis set in our previous paper two methods are proposed in the present investigation to meet this *** first one is to use the weighted average values for replacing the integrals *** second is a more stringent alternative,in which we have derived 690 nonzero hybrid one-center-two-electron integrals in addition to Coulomb and exchange types as expressions of Slater-Condon parameters.

关键词： invariance Slater rotational Coulomb stringent requirement symmetry nonzero replacing unitary

Luo Lin Appointed to Head of SAWS

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China Chemical Reporter 2009年第2期20卷 12-12页

On December 30th,2008 Luo Lin was appointed to theHead of the State Administration of Work Safety(SAWS)ofChina,replacing Wang Jun who was just assigned this positionon March 21st,*** predecessor of Wang Jun

关键词： appointed predecessor replacing assigned minister

Inevitable Oversupply of the MTBE Market

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China Chemical Reporter 2010年第12期21卷 27-28页

作者： Mi Duo,CNPC Jilin Research Institute of Petrochemical Industry

Reportedly,the total capacity to make methyltertbutyl ether (MTBE) in the worldwas 19.439 million t/a in 2009 and theMTBE output was 14.161 million *** to projection,the total capacityof making MTBE in the world will be reducedto 16.125 million t/a in 2011 and thenfurther to 15.575 million t/a by *** is expected to be 13.361 million tonsin 2011 and 13.371 million tons in *** main reason for the reduction is that in2005 the United States approved the RenewableFuel Standard (RFS) 2005 EnergyAct,which requires replacing MTBE

关键词： approved gasoline projection replacing constantly

Shijiazhuang will Build the World's Biggest replacingcopper-with-aluminum Cable Production Base

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China Nonferrous Metals Monthly 2014年第7期 8-8页

Shijiazhuang City will build the world’s biggest replacing-copper-with-aluminum cable production base,the annual output value can reach 100 billion yuan,in the future it will develop replacing-copper-with-aluminum highend industry *** piece of news was learned by the reporter at the Rare Earth highiron Aluminum Alloy[Nonferrous Business Opportunity:Aluminum alloy door]Cable Conductor New Technology Application Seminar held at the provincial capital.

关键词： provincial replacing reporter Seminar cable learne

Frank Hanraets Named MEGlobal Vice President Commercial

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China Chemical Reporter 2008年第19期19卷 7-7页

Effective July 1,Frank Hanraets has been named MEGlobal vice president commercial,replacing Ben Poon who is returning to a position within The Dow Chemical Com-pany (Dow).In his new role,Hanraets,currently serving as ... 详细信息

关键词： currently serving replacing president trading vent

China Supports Energy Conservation and Emission Reduction

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China Chemical Reporter 2008年第Z1期19卷 12-12页

Eleven enterprises in Ningxia including Fengyou Chemical Co.,*** Qingtongxia Huineng Thermal Power Co.,*** recently gained RMB85.05 mil-lion as energy

关键词： Reduction gained Eleven conservation replacing att