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Correlation Between Hyaluronic Acid,Hyaluronic Acid Synthase And Human renal clear cell carcinoma

Chinese Journal of Cancer Research 2011年第1期23卷 59-63页

作者： Jian-liang Cai Ming Li Yan-qun Na Peking University Wu Jieping Urological Center Peking University Shougang HospitalBeijing 100144China Key laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of UrologyPeking University School of OncologyBeijing Cancer Hospital ＆ InstituteBeijing 100142China

Objective：To study the correlation between hyaluronic acid（HA）,hyaluronic acid synthase（HAS） and human renal clear cell carcinoma（RCCC）.Methods：The expression of three HAS isoforms＇ gene and HA in 93 RCCC tissues,27 nephridial tissues by the side of RCCC from two hospitals were measured with Real-Time RT-PCR、Western Blot and immunohistochemical methods and ***：All RCCC and adjacent normal tissues expressed three HASs＇ mRNA protein;at the mRNA level,both RCCC and adjacent normal tissues,expressed more HAS3 than HAS1 or HAS2,their differences were statistically significant（all P values 0.05）;but,at the protein level,all HAS isoforms presented the equivalent *** with the adjacent non-neoplastic kidney tissues,the expression of all HAS isoforms＇ mRNA in RCCC tissues were increased evidently and their differences were significant（all P values 0.0001）;but at the protein level,only the expression of HAS3 increased evidently（P=0.022）.In all adjacent normal tissues,more than 80% renal tubular cells strongly expressed HA,however,only the minority RCCC cases（16/93） presented weakly positive HA staining in few cancer nests（5%-30%）,the difference were significant（P0.0001）.In RCCC tissues subgrouped according to clinical stage,pathological grade,lymphatic metastasis or not and distant metastasis or not,the HASs＇ mRNA protein differential expression all had no statistical significance（all P values 0.05）.Conclusion：Different from other malignancy,HA and HASs（except for HAS3） may not play important roles in the biological progress of human RCCC.

关键词： renal clear cell carcinoma Hyaluronic acid Hyaluronic acid synthase Gene

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Pembrolizumab combined with axitinib in the treatment of skin metastasis of renal clear cell carcinoma to nasal ala:A case report

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World Journal of Clinical Cases 2023年第9期11卷 2104-2109页

作者： Shuai Dong Yang-Chun Xu Yuan-Chen Zhang Jian-Xin Xia Yan Mou Department of Dermatology The Second Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina

BACKGROUND renal clear cell carcinoma(RCC)is a malignant tumor of the genitourinary system with a predilection for *** most common metastatic sites are the lung,liver,lymph nodes,contralateral kidney or adrenal gland,however,skin metastasis has only been seen in 1.0%-3.3%of *** most common site of skin metastasis is the scalp,and metastasis to the nasal ala region is *** SUMMARY A 55-year-old man with clear cell carcinoma of the left kidney was treated with pembrolizumab and axitinib for half a year after surgery and was found to have a red mass on his right nasal ala for 3 *** skin lesion of the patient grew rapidly to the size of 2.0 cm×2.0 cm×1.2 cm after discontinuation of targeted drug therapy due to the coronavirus disease 2019 *** patient was finally diagnosed with skin metastasis of RCC in our *** patient refused to undergo surgical resection and the tumor shrank rapidly after resuming target therapy for 2 *** It is rare for an RCC to metastasize to the skin of the nasal ala *** tumor size change of this patient before and after treatment with targeted drugs shows the effectiveness of combination therapy for skin metastasis.

关键词： Skin metastasis renal clear cell carcinoma Pembrolizumab Axitinib Case report

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Molecular subtypes based on DNA methylation predict prognosis in patients with renal clear cell carcinoma

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Medical Theory and Hypothesis 2022年第1期5卷 10-16页

作者： Xu-Dong Zhu Yang Shen Ming Yang Long-Long Tang Yuan-Yuan Ji Meng-Yu Sheng Huan Zhang Zhi-Yong Qu He-Song Ye Department of Urology The Second Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Second Chinese Medicine HospitalNanjing 210029China

Background:Tumor heterogeneity is closely related to the occurrence,progression and recurrence of renal clear cell carcinoma(ccRCC),making early diagnosis and effective treatment *** methylation is an important regulator of gene expression and can affect tumor ***:In this study,we investigated the prognostic value of subtypes based on DNA methylation status in 506 ccRCC samples with paired clinical data from the TCGA *** in DNA methylation levels were associated with differences in T,N and M categories,age,stage and ***,the samples were divided into the training group and the testing group according to 450K and *** and multivariate Cox regression analysis was used to construct the prediction model in the training group,and the model was verified and evaluated in the testing ***:By univariate Cox regression analysis,21,122 methylation sites and 6,775 CpG sites were identified as potential DNA methylation biomarkers for overall survival of ccRCC patients(P<0.05).3,050 CpG sites independently associated with prognosis were identified with T,N,M,stage and age as *** cluster of 3,050 potential prognostic methylation sites was used to identify different DNA methylation subsets of ccRCC for prognostic *** performed functional enrichment analysis on these 3,640 genes and identified 75 significantly enriched pathways(P<0.05).We then researched the expression of methylated genes in *** with the training set,suggesting that DNA methylation levels generally reflect the expression of these ***:Based on TCGA database and a series of bioinformatics methods,We identified prognostic specific methylation sites and established prognostic prediction models for ccRCC *** model helps to identify novel biomarkers,precision drug targets and disease molecular subtypes in patients with ***,this model may be useful in predicting the progno

关键词： DNA methylation renal clear cell carcinoma TCGA database prognostic prediction model bioinformatics

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An easy model for prediction of human renal clear cell carcinoma：curve fitting for three kidney tumors observed for over 10 years

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Chinese Medical Journal 2014年第4期127卷 782-783页

作者： Yao L Li XS Zhang L He ZS Zhou LQ Department of Urology Peking University First Hospital Beijing 100034 China Institute of Urology Peking University National Urological Cancer Center Beijing 100034 China

The current researches on natural history of small renal masses show that small renal tumors grow slowly,and few metastasize.1-4 As the length of follow-up is short in these studies （the longest mean follow-up time is 48 months）,changes in tumor size in vivo cannot be observed *** addition,the growth model of tumor is linear,and the average growth rate is used to reflect tumor growth in these ***,most malignant tumor growth curves were not *** may not be correct to assess the growth of tumors by linear models.

关键词： prediction model renal clear cell carcinoma

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THE SIGNIFICANCES AND EXPRESSIONS OF P27KIP1,CYCLINE AND KI-67 IN renal clear cell carcinoma

THE SIGNIFICANCES AND EXPRESSIONS OF P27KIP1,CYCLINE AND KI-...

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2010年贵州省泌尿外科学术会议

作者： SHEN Jun Department of Urology,The Affiliated Hospital,Guiyang Medical College,Guiyang, 550004,China

This paper was designed to investigate the expressions of p27kipl(p27) protein、cyclinE protein and ki-67 antigen in human renal clear cell carcinoma and in its adjacent tissue of carcinoma,and to explore the relationship between the expression level and clinico-pathological characteristics and prognosis in clear cell carcinoma of kidney cases.

关键词： renal clear cell carcinoma p27Kip1 cyclinE ki-67

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Ambiguous clear cell carcinoma in medullary sponge kidney:A case report

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Asian Journal of Urology 2020年第4期7卷 369-372页

作者： Yang Chen Tianyu Li Jiwen Cheng Department of Urology The First Affiliated Hospital of Guangxi Medical UniversityNanningChina

Medullary sponge kidney(MSK)is a characteristic renal malformation,with a relatively low ***,identification of MSK is sometimes ambiguous when compared to a renal ***,we report a novel renal clear cell carcinoma in MSK,and discuss our approach to *** recommended that a preoperative biopsy should be performed,followed by a comprehensive discussion regarding the appropriate perioperative preparations and careful surgical techniques that should be performed for this complex disease.

关键词： Medullary sponge kidney renal clear cell carcinoma Preoperative biopsy

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Study on the Mechanism of Ruanjian Sanjie Capsules(软坚散结胶囊)Inducing renal Cancer cell Apoptosis by Blocking NOTCH Signal Pathway

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World Journal of Integrated Traditional and Western Medicine 2020年第12期6卷 7-12页

作者： GAO Yu LIU Li-kun LI Yi-fang WANG Dong WANG Xi-xing Shanxi Provincial Hospital of Traditional Chinese Medicine Shanxi Provincial Institute of Traditional Chinese MedicineTaiyuan 030012China Graduate School of Shanxi Provincial Institute of Traditional Chinese Medicine Taiyuan 030012China

Objective:To investigate the molecular mechanism of Ruanjian Sanjie Capsules(软坚散结胶囊)through regulating NOTCH signaling pathway to promote human clear cell renal cell carcinoma 7860 cell ***:A laser confocal microscope was used to observe the nuclear displacement of apoptosis-related proteins,and the expression of Notch1,NICD,Bcl-2,and Bax was detected by Western blotting(WB).Results:Laser confocal microscopy showed that the immunofluorescence intensity of Bcl-2 protein gradually decreased with the increase of Ruanjian Sanjie Capsules(软坚散结胶囊)drug-containing serum concentration,and the fluorescence intensity of Bax protein gradually increased with the increase of dose concentration,and it entered the nucleus to varying degrees;WB detection showed that Bcl-2,Notch1,and NICD protein expression levels were inversely correlated with the drugcontaining serum dose concentration,that is,protein expression decreased with the increase of drugcontaining serum concentration,while Bax protein expression increased gradually with the increase of serum *** 7860 cells knock out Notch1,the expression of related proteins was consistent with the expression trend of the drug-containing serum ***:Ruanjian Sanjie Capsule's(软坚散结胶囊)low,medium and high dose concentration of drug-containing serum can promote 7860 cell apoptosis,and it is *** molecular mechanism of apoptosis is directly related with Ruanjian Sanjie Capsule(软坚散结胶囊)blocking Notch signaling pathway activation.

关键词： renal clear cell carcinoma Apoptosis Notch Ruanjian Sanjie Capsules(软坚散结胶囊)

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