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BIOcell 2021年第3期45卷 599-615页

作者： BENJIANG QIAN YOUFENG HUANG ZHENQIANG QIU XIAOYAN YING GUANG YANG HUIZHANG LI JIANMING TAN Fujian Provincial Key Laboratory of Transplant Biology Department of UrologyDongfang Hospital(900 Hospital of the Joint Logistics Team)School of MedicineXiamen UniversityFuzhou350025China Institute of Ningde Urological Research and Department of Urology Affiliated Mindong Hospital of Fujian Medical UniversityFu’an355000China Department of Neurology Affiliated Mindong Hospital of Fujian Medical UniversityFu’an355000China

Tet methylcytosine dioxygenase 2(TET2)acts as an antioncogene that is investigated in different *** the effects of TET2 in renal cell cancer(RCC)is still known ***,quantitative real-time PCR(qRT-PCR),Western blot,and immunofluorescence were performed to exam gene and protein *** proliferation was measured using cell Counting Kit-8(CCK-8).Transwell assay was performed to detect cell metastasis *** cytometry was performed to analyze the cell cycle and cell *** effects of TET2 on RCC growth in vivo was analyzed using a mouse xenograft *** found that TET2 and miR-200c were decreased in RCC tissues,and hypermethylation of miR-200c promoter was *** of TET2 promoted miR-200c expression by reducing miR-200c promoter ***,overexpression of TET2 or miR-200c suppressed cell growth and ***,knockdown of miR-200c could moderate TET2 mediated cell growth ***,we found miR-200c directly regulates Stearoyl-CoA desaturase(SCD)gene ***,in vivo experiment results confirmed that TET2 inhibited tumor *** conclusion,TET2 acts as an antioncogene in RCC by regulating the miR-200c-SCD axis and providing a potential target for RCC diagnosis and treatment.

关键词： TET2 miR-200c SCD renal cell cancer Tumor growth

miR-206 Inhibits renal cell cancer Growth by Targeting GAK

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Journal of Huazhong University of Science and Technology(Medical Sciences) 2016年第6期36卷 852-858页

作者： Chao WEI Shen WANG Zhang-qun YE Zhi-qiang CHEN Department of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Institute of Urology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

renal cell cancer(RCC)remains one of the most lethal types of cancer in *** RNAs(mi RNAs)play key roles in the pathogenesis of *** role of mi R-206 in RCC has not been fully *** purpose of this study was to examine the role of mi R-206 in the regulation of proliferation and metastasis of RCC and the possible *** R-206 expression was detected by reverse transcription?quantitative polymerase chain reaction(RT-q PCR)in RCC cell lines(786-O and OS-RC-2 cells)and clinical ***[3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium]method,colony formation and transwell assay were used to detect the tumor-suppressing ability of mi R-206 in *** assay was performed to verify the precise target of mi *** results showed that the expression of mi R-206 was significantly down-regulated in RCC tissues and *** expression level of cyclin G-associated kinase(GAK),a master regulator of tumor proliferation and metastasis,was up-regulated with the decrease in mi R-206 in RCC tissues as well as RCC cell *** addition,the mi R-206 inhibitor promoted the proliferation,migration and invasion of 786-O and OS-RC-2 *** combined with luciferase and Western blot assays revealed that mi R-206 inhibited the expression of ***,mi R-206 regulates RCC cell growth partly through targeting *** study indicated that mi R-206 functions as a tumor suppressor in regulating the proliferation,migration and invasion of RCC by directly targeting GAK,and it holds promises as a potential therapeutic target for RCC.

关键词： miR-206 renal cell cancer G-associated kinase

A Case Report: Metastasis of Clear cell Ovarian cancer in Morrison’s Pouch as Differential Diagnosis to Exophytic Kidney Tumor

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Open Journal of Urology 2016年第11期6卷 173-177页

作者： Stine Lohmann Anna Krarup Keller Department of Urology Regional Hospital West Holstebro Denmark Department of Urology Aarhus University Hospital Aarhus Denmark

A 62-year-old woman with a history of curatively treated mucinous ovarian cancer, presented with dyspnea, anorexia and right-upper-quadrant pain at consultation with her general practitioner. A CT scan revealed several lymph node metastases in lungs and abdomen as well as a tumor in Morrison’s pouch and biopsy revealed renal cell carcinoma. Therefore, she was referred to Department of Urology. The multidisciplinary team could not immediately reject that there could be an exophytic tumor in the right kidney but discrepancy between histology and imaging, led to several biopsies including laparoscopic procedure. Re-examination of the primary ovarian cancer showed that one percent was classified as clear cell carcinoma. The final diagnose was metastatic clear cell ovarian carcinoma. The patient was terminal and suffered of cachexia and pleural effusion. The patient deceased four months after first consultation.

关键词： Ovarian cancer Clear cell Adenocarcinoma renal cell cancer Immunohistochemistry

Concurrent renal cell carcinoma and hematologic malignancies: Nine case reports

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World Journal of Clinical Oncology 2020年第8期11卷 644-654页

作者： Lisa BE Shields Arash Rezazadeh Kalebasty Norton Neuroscience Institute Norton HealthcareLouisvilleKY 40202United States Norton cancer Institute Norton HealthcareLouisvilleKY 40202United States

BACKGROUND The presence of renal cell carcinoma(RCC)and hematologic malignancies(HM)in the same patient is rarely *** primary findings have been described in these patients,including male gender and lymphoid malignancy predominance,and the HM are usually diagnosed before or simultaneously with the *** is a lack of evidence about clinical outcomes in this *** report the common characteristics of 9 patients diagnosed with concurrent RCC and HM and their clinical course and response to *** SUMMARY Four(44%)patients were diagnosed with RCC prior to the HM,the diagnosis was simultaneous in 4(44%)patients,and 1(11%)patient was diagnosed with the HM prior to the *** patients were treated with cytotoxic chemotherapy or radiation between the diagnosis of RCC and *** unique features were seen in our case series,such as 3 simultaneous cancers in 1(11%)patient,a splenectomy leading to remission of diffuse large B cell lymphoma without the use of chemotherapy in 1(11%)patient,chemotherapy and rituximab for lymphoma resulting in a complete response in primary RCC in 1(11%)patient,and immunotherapy providing an excellent response for primary renal leiomyosarcoma in 1(11%)*** These findings highlight the potential role of immune system dysregulation in patients with the diagnosis of RCC and HM whereby the first malignancy predisposes to the second through an immunomodulatory *** have the potential of being confused with lymph node metastasis from kidney *** node biopsy may be necessary at the time of initial diagnosis or in cases of mixed response to ***-term medical surveillance is warranted when a patient is diagnosed with RCC or *** should be aware of the higher prevalence of male gender and lymphoid malignancy with concurrent RCC and HM and that either of these conditions may be diagnosed first or they may be diagnosed simultaneously.

关键词： Oncology renal cell cancer Hematologic malignancy Lymphoma Immune system Immunotherapy Case report

Comparative Effectiveness of Median Sternotomy vs Minimal Access Cardiopulmonary Bypass and Circulatory Arrest for Resection of renal cell Carcinoma with Inferior Vena Caval Extension

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Journal of cancer Therapy 2016年第10期7卷 752-761页

作者： William C. Faust Richard S. D’Agostino John Libertino Mystic Valley Urology Associates Stoneham MA USA Lahey Hospital and Medical Center Burlington MA USA

Introduction: The use of cardiopulmonary bypass (CPB) with deep hypothermic circulatory arrest (DHCA) is an adjunctive surgical technique that can be employed for the resection of renal cell carcinoma (RCC) with venous thrombus extension superior to the level of the hepatic veins. Median Sternotomy (MS) or Minimal Access (MA) incisions may be used to establish CPB during the resection of these extensive tumors. We review our experience with both incisional approaches and compareoperative details, perioperative complications, and recurrence free survival. Materials and Methods: From 1986 to 2012, 70 radical nephrectomies with concomitant inferior vena cava (IVC) thrombectomies were performed at our institution using MS (23 patients) and MA (47 patients) techniques. Preoperative patient characteristics, pathologic data, and organ specific postoperative complications and follow-up data were compared between groups. Estimates of overall and recurrence-free survival were constructed using Kaplan-Meier curves and compared using log-rank testing. Results: There were no significant differences with respect to patient demographics or preoperative comorbid conditions between the MA and MS groups. The MA group showed a significant reduction (p 0.05) in the duration of postoperative mechanical ventilation, length of stay, operative time, and number of blood transfusions compared to MS patients. Overall and organ-system specific complications demonstrated a decreased incidence of wound infection (37.9% v. 12.5%, p = 0.0135) and sepsis (14.3% v. 0%, p = 0.0137) in patients undergoing MA approach. Perioperative mortality was significantly reduced in the MA group (30.4% v. 8.5% p = 0.0179). Recurrence-free survival in the MS group was 0.59 years and 1.2 years in the MA group (p = 0.06). Conclusions: Minimal access surgical approaches for CPB and DHCA during the resection of RCC with extensive tumor thrombus provide similar oncologic control with decreased duration of mechanical ven

关键词： renal cell cancer Kidney cancer Inferior Vena Cava Caval Thrombus