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Release behavior and kinetic evaluation of berberine hydrochloride from ethyl cellulose/chitosan microspheres

Frontiers of Materials Science 2014年第4期8卷 373-382页

作者： Hui-Yun ZHOU Pei-Pei CAO Jie ZHAO Zhi-Ying WANG Jun-Bo LI Fa-Liang ZHANG Chemical Engineering & Pharmaceutics College Henan University of Science and Technology Luoyang 471023 China

Novel ethyl cellulose/chitosan microspheres （ECCMs） were prepared by the method of w/o/w emulsion and solvent evaporation. The microspheres were spherical, adhesive, and aggregated loosely with a size not bigger than 5 pm. The drug loading efficiency of berberine hydrochloride （BH） loaded in microspheres were affected by chitosan （CS） concentration, EC concentration and the volume ratio of V（CS）/V（EC）. ECCMs prepared had sustained release efficiency on BH which was changed with different preparation parameters. In addition, the pH value of release media had obvious effect on the release character of ECCMs. The release rate of BH from sample B was only a little more than 30% in diluted hydrochloric acid （dHCl） and that was almost 90% in PBS during 24 h. Furthermore, the drug release data were fitted to different kinetic models to analyze the release kinetics and the mechanism from the microspheres. The released results of BH indicated that ECCMs exhibited non-Fickian diffusion mechanism in dHCI and diffusion-controlled drug release based on Fickian diffusion in PBS. So the ECCMs might be an ideal sustained release system especially in dHCl and the drug release was governed by both diffusion of the drug and dissolution of the polymeric network.

关键词： ethyl cellulose (EC) chitosan (CS) microsphere release in vitro releasekinetics

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