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Enriched environment enhances histone acetylation of NMDA receptor in the hippocampus and improves cognitive dysfunction in aged mice

引用

Neural Regeneration Research 2020年第12期15卷 2327-2334页

作者： Xin Wang Zhao-Xiang Meng Ying-Zhu Chen Yu-Ping Li Hong-Yu Zhou Man Yang Ting-Ting Zhao Yu-Lai Gong Yi Wu Tao Liu Department of Rehabilitation Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Rehabilitation Clinical Medical CollegeYangzhou UniversityYangzhouJiangsu ProvinceChina Department of Rehabilitation First Affiliated HospitalDalian Medical UniversityDalianLiaoning ProvinceChina Department of Rehabilitation Medicine Sichuan Provincial Rehabilitation Hospital Affiliated to Chengdu University of TCMChengduSichuan ProvinceChina South China Research Center for Acupuncture and Moxibustion Medical College of Acu-Moxi and RehabilitationGuangzhou University of Chinese MedicineGuangzhouGuangdong ProvinceChina

The mechanisms of age-associated memory impairment may be associated with glutamate receptor function and chromatin *** observe the effect of an enriched environment on the cognitive function of mice with age-associated memory impairment,3-monthold C57BL/6 male mice("young"mice)were raised in a standard environment,while 24-month-old C57BL/6 male mice with memory impairment("age-associated memory impairment"mice)were raised in either a standard environment or an enriched *** enriched environment included a variety of stimuli involving movement and sensation.A water maze test was then used to measure cognitive function in the ***,quantitative real-time polymerase chain reaction and western blot assays were used to detect right hippocampal GluN2B mRNA as well as protein expression of GluN2B and CREB binding protein in all *** addition,chromatin immunoprecipitation was used to measure the extent of histone acetylation of the hippocampal GluN2B gene *** with the young mice,the water maze performance of age-associated memory impairment mice in the standard environment was significantly *** addition,there were significantly lower levels of total histone acetylation and expression of CREB binding protein in the hippocampus of age-associated memory impairment mice in the standard environment compared with the young *** were also significantly lower levels of histone acetylation,protein expression,and mRNA expression of GluN2B in the hippocampus of these *** contrast,in the age-associated memory impairment mice with the enriched environment intervention,the water maze performance and molecular biological indexes were significantly *** data confirm that an enriched environment can improve cognitive dysfunction in age-associated memory impairment mice,and suggest that the mechanisms may be related to the increased expression of CREB binding protein and the increased degree of total histone a

关键词： brain central nervous system factor in vitro model mice recovery regenerations protein

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