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Association of eleven single nucleotide polymorphisms with refractive disorders from Eskisehir,Turkey

International Journal of Ophthalmology(English edition) 2021年第6期14卷 812-817页

作者： Nadir Unlu Ebru Erzurumluoglu Gokalp Serap Arslan Oguz Cilingir Muzaffer Bilgin Engin Yildirim Huseyin Gursoy Department of Ophthalmology Eskisehir Osmangazi University Medical FacultyEskisehir 26040Turkey Department of Medical Genetics Eskisehir Osmangazi University Medical FacultyEskisehir 26040Turkey Department of Biostatistics Eskisehir Osmangazi University Medical FacultyEskisehir 26040Turkey Department of Pharmacology Eskisehir Osmangazi University Medical FacultyEskisehir 26040Turkey

AIM:To investigate relationship between refractive errors and eleven single nucleotide polymorphisms(SNPs)in HGF,GC,MFN1,GNB4,and VDR genes in Turkish ***:A group of 212 participants with myopia(n=91),hyperopia(n=45),and emmetropia(n=76)were investigated in this *** in HGF,GC,MFN1,GNB4 and VDR genes were studied by Snap Shot ***:The patients in this study consists of 47 female/44 male(age:23.47±4.30)patients with myopia,20 female/25 male(age:31.20±8.02)with hyperopia and 33 female/43 male(age:25.22±6.60)with *** genotype distribution of the rs7618348 polymorphism,which was the only statistically significant one between myopia and emmetropia *** genotype distribution of the rs3819545,rs3735520,rs7041,and rs2239182 polymorphisms,which were statistically significant between hyperopia and emmetropia ***:The importance of genetic predisposition to refractive errors with respect to etiology of the disease is *** is known that polymorphism studies may differ because of genetic diversity among populations so larger cohort studies are required in different populations to enlighten the etiology of the refractive errors.

关键词： refractive disorders myopia hyperopia genetics single nucleotide polymorphisms Turkey

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