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Changes in the esophageal mucosa of patients with non erosive reflux disease:How far have we gone?

World Journal of Gastroenterology 2015年第19期21卷 5762-5767页

作者： Christos Triantos Nikolaos Koukias Georgios Karamanolis Konstantinos Thomopoulos Department of Gastroenterology University Hospital of Patras Gastroenterology Unit 2nd Department of Surgery "Aretaieio" University Hospital Athens University

The normal esophageal mucosa creates a protective epithelial barrier that constrains the acidic reflux in the esophageal lumen. Microscopic findings and functional studies indicate that this barrier might be impaired in patients with non erosive reflux disease(NERD) but not in patients with functional heartburn(FH). Whereas endoscopy and pH monitoring are the most important diagnostic tools in the diagnosis of NERD, recent studies suggest that esophageal biopsies might have a complementary role. Particularly in the differential diagnosis between NERD and FH, the application of histological severity scores showed very promising results. Further evaluation of the scores could lead to routine application of histology in specific NERD populations.

关键词： Esophageal mucosa Non erosive refluxdisease

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From reflux esophagitis to Barrett's esophagus and esophageal adenocarcinoma

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World Journal of Gastroenterology 2015年第17期21卷 5210-5219页

作者： Rui-Hua Wang Department of Gastroenterology Shanghai Jiao Tong University affiliated Sixth People’s Hospital South Campus

The occurrence of gastroesophageal reflux disease is common in the human *** all cases of esophageal adenocarcinoma are derived from Barrett's esophagus,which is a complication of esophageal adenocarcinoma precancerous *** exposure of the esophagus to gastroduodenal intestinal fluid is an important determinant factor in the development of Barrett's *** replacement of normal squamous epithelium with specific columnar epithelium in the lower esophagus induced by the chronic exposure to gastroduodenal fluid could lead to intestinal metaplasia,which is closely associated with the development of esophageal ***,the exact mechanism of injury is not completely *** animal models of the developmental mechanisms of disease,and theoretical and clinical effects of drug treatment have been widely used in ***,animal models employed in studies on gastroesophageal reflux injury have allowed significant *** advantage of using animal models lies in the ability to accurately control the experimental conditions for better evaluation of *** this article,various modeling methods are reviewed,with discussion of the major findings on the developmental mechanism of Barrett's esophagus,which should help to develop better prevention and treatment strategies for Barrett's esophagus.

关键词： Animal models Gastroesophageal refluxdisease Reflux esophagitis Barrett's esophagus Esophageal adenocarcinoma

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