检索结果-南通市图书馆

Nickel-catalyzed reductive coupling reaction of monofluoroalkyl triflates with alkyl carboxylic acids toward the synthesis of α-alkyl-α-fluoro-alkylketones

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第10期34卷 163-167页

作者： Rui Wang Jie Xu Jin-Xiao Li Bing-Bing Wu Ruo-Xing Jin Yu-Xiang Bi Xi-Sheng Wang Key Laboratory of Precision and Intelligent Chemistry University of Science and Technology of ChinaHefei 230026China

The synthesis methods ofα-fluoro-arylketones were well-established through electrophilic/nucleophilic fluorination and transition metal catalyzed ***,due to the site selectivity and substrate restriction,only a few cases have been developed to affordα-alkyl-α-***,we report a general and efficient method of preparing diverseα-alkyl-α-fluoro-alkylketones via nickelcatalyzed reductive coupling reaction of monofluoroalkyl triflates with low-cost industrial raw material alkyl carboxylic *** transformations demonstrate high efficiency,mild conditions,and excellent functional group *** strategy provides a general and efficient method for the synthesis ofα-alkyl-α-fluoro-alkylketones。

关键词： Ni-catalyzed reductive coupling α-Fluoroketones α-Alkyl-α-fluoro-alkylketones Monofluoroalkyl triflates

Diastereoselective and Enantioselective Nickel-Catalyzed reductive coupling of Imines and Unactivated Alkenes

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2023年第4期5卷 814-822页

作者： Biao Wang Xian-Ming Liu Kai-Xiang Zhang Wei-Min Feng Li-Jun Xiao Qi-Lin Zhou State Key Laboratory and Institute of Elemento-Organic Chemistry College of ChemistryNankai UniversityTianjin 300071

Herein we report a method for highly diastereoselective and enantioselective nickel-catalyzed reductive coupling of imines and unactivated alkenes.A monodentate chiral spiro phosphoramidite ligand is the key to controlling the *** efficient,straightforward method allows for the construction of chiral benzocyclic and indole-fused cyclic amines with two contiguous stereogenic centers in good yields from readily accessible starting materials.

关键词： nickel catalysis enantioselective alkenes imines reductive coupling

Ni-Catalyzed reductive coupling of tertiary Alkyl Halides

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Ni-Catalyzed Reductive Coupling of tertiary Alkyl Halides

Nickel-Catalyzed reductive coupling of Two Electrophiles: Selectivity and Reactivity

中国化学会全国第十一届有机合成化学学术研讨会

作者： Chenglong Zhao Xuan Wang 龚和贵 Department of Chemistry Shanghai University

Ni-catalyzed reductive cross-coupling of alkyl halides with other electrophiles such as alkyl and aryl halides,allylic carbonates and acid derivatives have been successfully *** reactions provide facile protocols to the construction C-C bonds,featuring excellent functional group tolerance and broad substrate scope unde mild ***,the reductive coupling strategy can be successfully applied to the coupling of unactivated tertiary alkyl halides with aryl halides and acid *** processes allows efficient synthesis of quaternary carbon compounds without pre-preparation of organometallic reagents.

关键词： Ni-catalyzed reductive coupling tertiary alkyl halides

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Nickel-Catalyzed Reductive Coupling of Two Electrophiles: Se...

Mn-mediated reductive C(sp3)–Si coupling of activated secondary alkyl bromides with chlorosilanes

中国化学会第十四届全国有机合成化学学术研讨会

作者： JiANDong Liu Xuan Wang Hegui Gong Department of Chemistry Shanghai University

Ni-catalyzed reductive cross-coupling of alkyl halides with other electrophiles has provided facile protocols to the construction C–C bonds, featuring excellent functional group tolerance and broad substrate scope under mild conditions. While primary and secondary alkyl halides have been extensively studied, the tertiary alkyl counterparts proved to be more challenging. Recently, our group has disclosed highly effective methods for the coupling of unactivated tertiary alkyl halides with aryl halides and acid derivatives. These processes enabled efficient synthesis of quaternary carbon compounds without pre-preparation of organometallic reagents. With our continuing endeavors, the more difficult all quaternary carbon centers constituting C(sp)–C(sp) bonds has also been achieved.

关键词： reductive coupling electrophiles nickel

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第12期33卷 5061-5064页

作者： Liangliang Qi Xiaobo Pang Kai Yin Qiu-Quan Pan Xiao-Xue Wei Xing-Zhong Shu State Key Laboratory of Applied Organic Chemistry(SKLAOC) College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China School of Chemistry and Chemical Engineering Southeast UniversityJiangsu Optoelectronic Functional Materials and Engineering LaboratoryNanjing 211189China Zhejiang Nanjiao Chemistry Co. Ltd.Shangyu Economic and Technological Development ZoneShangyu 312369China

The construction of secondary alkylsilanes is a challenging subject in the synthetic *** cross-coupling provides a practical solution to address this problem,but it typically relies on organometallic ***,we report an Mn-mediated reductive C(sp^(3))-Si coupling to synthesize these compounds from alkyl and silyl *** approach avoids the requirement for activation of Si-Cl by transition metals and thus allows for the coupling of various common *** reaction proceeds under mild conditions and shows good functional group *** method offers access toα-silylated organophosphorus and sulfones with a scope that is complementary to those obtained from the established methods.

关键词： Organosilanes Alkylsilanes reductive coupling Chlorosilanes Organophosphorus Sulfones

Bioinspired zinc-mediated umpolung thiolation of alkyl electrophiles: reaction development, scope and mechanism

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第3期67卷 898-907页

作者： Yuenian Xu Yan Zhang Yong Liu Wen-Wu Sun Jie Huang Hui He Yingjie Wu Wen Liu Shao-Fei Ni Xu-Qiong Xiao Xinxin Shao College of Material Chemistry and Chemical EngineeringKey Laboratory of Organosilicon Chemistry and Material Technology of Ministry of EducationHangzhou Normal UniversityHangzhou 311121China School of Pharmaceutical Sciences South-Central Minzu UniversityWuhan 430074China Department of Chemistry and Key Laboratory for Preparation and Application of Ordered Structural Materials of Guang-dong Province Shantou UniversityShantou 515063China

Zinc-promoted umpolung thiolation of alkyl electrophiles with masked sulfur transfer reagents in the absence of nickel or copper catalysis is described. This protocol proceeds via a SET process of Zn to electrophilic sulfur reagent followed by insertion of Zn into disulfide and nucleophilic thiolation, providing straightforward access to a wide range of alkyl sulfides with broad substrate scope. A neutral TMEDA-ligated four-coordinated zinc thiolate with tetrahedra geometry was synthesized, isolated and fully characterized by NMR, IR and X-ray analysis. More importantly, the chemical reactivity of this active intermediate has been investigated, enabling the construction of C-Se, C-Te, Sb-S and Bi-S bonds to prepare valuable sulfur-containing molecules and beyond.

关键词： umpolung thiolation C(sp^(3))-S bond formation masked sulfur reagents reductive coupling

同方期刊数据库

Nickel-catalyzed cross-electrophile C–Ge coupling of benzyl pivalates and chlorogermanes

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2023年第12期66卷 3562-3566页

作者： Ming-Xiang You Pei-Feng Su Ze-Hui She Xing-Zhong Shu State Key Laboratory of Applied Organic Chemistry(SKLAOC) College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000China

The C–Ge cross-coupling offers a promising approach for the precise synthesis of organogermanes. However, the current methods are primarily effective in the germylation of organo(pseudo)halides. This work demonstrates the possibility of transferring low-cost and easily available ester groups into organogermanes through the cleavage of stable C–O bonds. Primary,secondary, and even tertiary benzylic pivalates were coupled well with chlorogermanes. The reactions proceed under mild conditions. The scalability of this reaction and derivatization of the formed benzylgermanes are demonstrated.

关键词： nickel cross-coupling reductive coupling germanium germylation

Nickel-Catalyzed Cross-Electrophile Vinyl–Vinyl coupling:An Approach to Structurally Versatile Dienylboronates

在线全文

学校读者我要写书评

暂无评论

CCS Chemistry 2022年第3期4卷 864-871页

作者： Guang-Li Xu Chun-Yan Liu Xiaobo Pang Xue-Yuan Liu Xing-Zhong Shu State Key Laboratory of Applied Organic Chemistry(SKLAOC) College of Chemistry and Chemical EngineeringLanzhou UniversityLanzhou 730000

Cross C–C bond formation of two vinyl electrophiles is a long-standing challenge in synthetic ***,we report a nickel-catalyzed reductive vinyl–vinyl coupling between vinyl triflates and boron-substituted vinyl *** new protocol offers facile access to dienylboronates with high structural complexity and molecular *** reaction proceeds with a broad substrate scope under very mild *** synthetic utility of the method is highlighted by its gram-scale reaction,modification of complex molecules,and diverse transformation of the products.

关键词： nickel boron dienes cross-coupling reductive coupling

Nickel-catalyzed reductive formylation of aryl halides via formyl radical

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第12期35卷 476-481页

作者： Xiao-Bo Liu Ren-Ming Liu Xiao-Di Bao Hua-Jian Xu Qi Zhang Yu-Feng Liang School of Food and Biological Engineering School of Chemistry and Chemical EngineeringAnhui Province Key Laboratory of Advance Catalytic Materials and Reaction EngineeringHefei University of Technology School of Chemistry and Chemical Engineering Shandong University Institute of Industry&Equipment Technology Hefei University of Technology

Aromatic aldehydes are the most fundamentally important compounds used in organic *** development of new synthetic methods for introduction of a formyl group into an organic scaffold is highly *** this report,a nickel-catalyzed reductive coupling between aryl halides and α–chloro N-methoxyphthalimide has been documented for the synthesis of a diverse array of aromatic *** of mild reductive coupling conditions,excellent functional group tolerance,especially for substrates containing free-OH and-NH2,was *** to the simple operation mode,a large library of aromatic aldehydes can be quickly constructed by this ***,the present protocol is amenable for late-stage functionalization of bioactive compound.A combined computational and experimental investigation suggested the reaction may undergo a reaction mechanism of active Ni（I） catalyst formation and the formation of key formyl radical intermediate under zinc reductive conditions.

关键词： Nickel Formylation Radical SET reductive coupling